Clinical trials: Gastroesophageal Reflux
Venous Ulcer
Axial Ablation Versus Terminal Interruption of the Reflux Source
This randomised trial aims to compare the effect on ulcer healing of different means of managing venous reflux in the lower limb.
- Trial name
- AAVTIRS (NCT04484168)
- Testing
- Terminal Interruption of the Reflux Source, Axial Ablation
- Where
- Ireland
- Volunteers
- 308 people
- Sponsor
- University College Hospital Galway
Tricuspid Regurgitation
Edwards CLASP TR EFS
Early feasibility study to assess the safety and performance of the Edwards PASCAL Transcatheter Valve Repair System in tricuspid regurgitation
- Trial name
- CLASP TR EFS (NCT03745313)
- Testing
- Edwards PASCAL Transcatheter Valve Repair System
- Where
- 15 sites in United States
- Volunteers
- 65 people
- Sponsor
- Edwards Lifesciences
Other Specified Disorders of Kidney and Ureter, Benign Neoplasm of Ureter
Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery
The goal of this clinical trial is to learn whether the addition of spinal analgesia leads to superior recovery in patients undergoing robotic-assisted laparoscopic upper urinary tract surgery under general anesthesia.
- Conditions
- Other Specified Disorders of Kidney and Ureter, Benign Neoplasm of Ureter, Calculus of Kidney and Ureter, Ureter Cancer
- Trial name
- SMILe (NCT06349668)
- Testing
- spinal analgesia with morphine and bupivacaine, lidocaine infusion
- Where
- 3 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Hans Bahlmann
Gastroesophageal Reflux, Bariatric Surgery Candidate
Mucosal Impedance Sleeve Gastrectomy
Obesity is a growing epidemic and bariatric surgery has been shown to be the most effective and efficient mean of achieving significant and sustainable weight loss in morbidly obese individuals.
- Trial name
- NCT04166461
- Testing
- Not application, observational study
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- MetroHealth Medical Center
Gastroesophageal Reflux, Fundoplication
Mayo Clinic Foregut Surgery Report Card Questionnaire
The Mayo Clinic Foregut Surgery Report Card Questionnaire has been created in order to have a consistent evaluation tool for patients undergoing foregut surgery in order to standardize and validate outcome measures.
- Conditions
- Gastroesophageal Reflux, Fundoplication, Hernia, Hiatal, Surveys and Questionnaires
- Trial name
- NCT02708303
- Testing
- Mayo Clinic Foregut Surgery Report Card Questionnaire
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Mayo Clinic
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) poses a challenging medical condition to manage, with up to 40% of patients showing refractory to standard medical intervention, which usually begins with a proton pump inhibitor (PPI).
- Trial name
- NCT06778824
- Testing
- Takepron, Zoloft 50Mg Tablet, Imipramine Pill
- Where
- Taiwan
- Volunteers
- 610 people
- Sponsor
- Hualien Tzu Chi General Hospital
Barrett Esophagus, Dysplasia
Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease
This pilot clinical trial studies how well a swallowable sponge cell sampling device and next generation sequencing work in detecting esophageal cancer in patients with low or high grade dysplasia, Barrett esophagus, or…
- Conditions
- Barrett Esophagus, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02890979
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- OHSU Knight Cancer Institute
Gastroesophageal Reflux Disease
The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms
Gastroesophageal reflux disease is increasing worldwide. The causes of reflux symptoms are not found exactly. especially, the postprandial reflux symptoms are more common than the all day reflux symptoms.
- Trial name
- NCT02154659
- Testing
- 24hr pH monitoring
- Where
- South Korea
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Gastroesophageal Reflux Disease (GERD)
Efficacy and Safety of DLBS2411 in the Management of GERD
This is a 2-arm, prospective, double-blind double-dummy, randomized-controlled study comparing DLBS2411 at a dose of 250 mg twice daily with omeprazole at a dose of 20 mg twice daily, given before morning and evening meals, for…
- Trial name
- NCT03367195
- Testing
- Omeprazole, DLBS2411
- Where
- 5 sites in Indonesia
- Volunteers
- 32 people
- Sponsor
- Dexa Medica Group
Esophageal Achalasia
Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per Oral Endoscopic Myotomy for Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) is a treatment of choice for achalasia with an excellent safety and efficacy profile. There is a high rate of esophagitis related to gastroesophageal reflux following this procedure.
- Trial name
- IPPOEM (NCT05899842)
- Testing
- Protein pump inhibitor therapy systematically
- Where
- 4 sites in France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Varicose Veins, Venous Reflux
A Singapore Venaseal Real World Post-Market Evaluation Study
The study aims to assess the efficacy of VenaSeal™ Closure System (VCS) for the treatment of lower extremity superficial truncal veins in a real-world clinical setting, in a multi-racial Asian population in Singapore.
- Conditions
- Varicose Veins, Venous Reflux, Chronic Venous Insufficiency
- Trial name
- ASVS (NCT03893201)
- Testing
- Questionnaires
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore General Hospital
Obesity
Long Term Results After Sleeve Gastrectomy
Today sleeve gastrectomy is the most performed bariatric procedure worldwide. Since 2005 it is gaining popularity as a single procedure. Long term data is scarce.
- Trial name
- NCT02947412
- Testing
- laparoscopic sleeve gastrectomy
- Volunteers
- 40 people
- Sponsor
- Sana Klinikum Offenbach
Paraesophageal Hernia, Gastro Esophageal Reflux
Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.
Short-term follow up after surgery of para-esophageal hernia comparing two different types of fundoplication
- Trial name
- NCT04436159
- Testing
- Addition of 360 fundoplication after crural closure, Addition of 180 posterior fundoplication after crural closure
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital
Gastroesophageal Reflux Disease, GERD
Treatment Use of Domperidone for Gastroparesis
Domperidone is a drug that may be of benefit to individuals with gastroesophageal reflux disease (GERD), with upper GI symptoms, gastroparesis, and chronic constipation.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Gastroparesis
- Trial name
- NCT02227927
- Testing
- Domperidone
- Where
- 2 sites in United States
- Sponsor
- Scott Gabbard, MD
Chronic Obstructive Pulmonary Disease, Bronchiectasis
The Prevalence of Gastro-oesophageal Reflux in Chronic Lung Disease
Gastric reflux into the oesophagus may further lung damage in respiratory disease. The proportion of adults with chronic lung disease and gastric reflux is unknown.
- Trial name
- NCT00697177
- Where
- Australia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Gastroesophageal Reflux
Can Individuals Control Pressure in Their Esophagus.
To establish to what degree individuals can increase esophageal high pressure zone (HPZ) after instruction in deep breathing as evidenced by concurrent manometric pressure readings.
- Trial name
- manometry (NCT03495219)
- Testing
- Esophageal Manometry
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
GERD
A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers
A study to investigate the effect of food on the Pharmacokinetics and pharmacodynamics of CKD-381 in healthy volunteers
- Trial name
- NCT04830930
- Testing
- CKD-381
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux Disease, Reflux, Gastroesophageal
Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg.
Current treatment for gastroesophageal reflux disease(GERD)confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric acid suppression.
- Trial name
- NCT00551473
- Testing
- Lavoltidine
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Achalasia Cardia, Gastroesophageal Reflux
To Investigate the Incidence of Reflux in Patients After Per-oral Endoscopic Myotomy in Achalasia Cardia Patients
Achalasia is a rare motility disorder of the oesophagus that is characterized by aperistalsis of the oesophagal body and dysrelaxation of the lower oesophagal sphincter (LES).
- Trial name
- NCT04951739
- Testing
- Peroral endoscopic myotomy
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
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