Clinical trials: Gastroesophageal Reflux
Gastroesophageal Reflux Disease
Effect of Long-Term Electrical Stimulation on LES Pressure and Esophageal Acid Exposure in Patients With GERD
The EndoStim LES Stimulation System is an investigational device intended to improve the LES pressure and restore Lower Esophageal Sphincter (LES) function in individuals suffering from Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT01574339
- Testing
- EndoStim LES Stimulation System
- Where
- 10 sites in Chile, Colombia and 6 more
- Volunteers
- 42 people
- Sponsor
- EndoStim Inc.
Laryngopharyngeal Reflux, Hypertrophy of Lingual Tonsil
Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy
Main Hypothesis: The investigators hypothesize that measurements of lingual tonsil tissue (LTT) thickness will decrease following treatment with once daily oral dexlansoprazole 60 mg in patients diagnosed with laryngopharyngeal…
- Trial name
- NCT01328652
- Testing
- dexlansoprazole
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Advanced Center for Specialty Care
Cough
Esophageal Motility in Reflux Induced Cough
To determine whether contraction abnormalities in the esophagus plays a role in gastroesophageal reflux induced cough, and thus cough severity in patients with chronic cough.
- Trial name
- NCT02492126
- Testing
- Citric Acid
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease
A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients
The aim of this study is to compare the effectiveness of laparoscopic Nissen against anterior partial fundoplication in the control of gastroesophageal reflux disease among Chinese patients Study hypothesis Laparoscopic Nissen is…
- Trial name
- NCT00480285
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic anterior partial fundoplication
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Ulcer, Gastric, Bile Reflux
Evaluation of Biliary Reflux After Mini-gastric Bypass With Using the Biliary Reflux Index
MGB is considered to be the best alternative to Roux-en-Y gastric bypass (RYGB) due to the shorter operation time and fewer possible complications.
- Trial name
- NCT04845438
- Testing
- fibrogastroscopy, biopsy of the gastric mucosa, microscopy biopsy materials, using Bile Reflux Index
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Private Healthcare Institution Clinical Hospital RGD-Medicine
Hiatal Hernia Large, Gastro Esophageal Reflux
LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm
The cohort registry is both retrospective and prospective, multicenter surveillance of subjects who underwent a prior hiatal hernia repair and Magnetic Sphincter Augmentation or fundoplication construction more than 2 years prior…
- Conditions
- Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal
- Trial name
- NCT04695171
- Testing
- LINX Reflux Management System, Fundoplication
- Where
- 6 sites in United States
- Volunteers
- 336 people
- Sponsor
- Foregut Research Foundation
Gastro Esophageal Reflux
The Effect of Autonomic Modulation on Symptoms in Patients With Reflux Hypersensitivity
Reflux hypersensitivity is the disease that causes chest pain, heartburn and regurgitation and can impair patients' quality of life.
- Trial name
- NCT04253444
- Testing
- slow deep breathing
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Gastroesophageal Reflux Disease, Apnea Infants
Gastroesophageal Reflux and Cardiorespiratory Problems
Cardiorespiratory and gastroesophageal reflux events often coexist in infants in Neonatal Intensive Care Unit (NICU) thus leading to drugs over-prescription and delayed discharge.
- Conditions
- Gastroesophageal Reflux Disease, Apnea Infants, Desaturation of Blood, Bradycardia
- Trial name
- CR-GER (NCT03053609)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Turin, Italy
Pancreatic Pseudocyst
Clinical Evaluation of Enteral-extended Anti-reflux Stents for Pancreatic Pseudocyst
At present, endoscopic therapy is the preferred method to solve biliary or pancreatic diseases. And EUS-guided stent implantation and drainage of pancreatic pseudocyst is the main method in Endoscopic treatment of pancreatic…
- Trial name
- NCT05716594
- Testing
- Plant enteral-extended anti-reflux stents, Plant traditional stents
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Gastroesophageal Reflux, Bariatric Surgery Candidate
Mucosal Impedance Sleeve Gastrectomy
Obesity is a growing epidemic and bariatric surgery has been shown to be the most effective and efficient mean of achieving significant and sustainable weight loss in morbidly obese individuals.
- Trial name
- NCT04166461
- Testing
- Not application, observational study
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- MetroHealth Medical Center
Achalasia, GORD
vMII for Measurement of Oesophageal Bolus Transport and Reflux
Recent work at St. Thomas' has validated an innovative new design of a multichannel intraluminal impedance (MII) catheter that is sensitive to variation in oesophageal volume in healthy volunteers and patients.
- Trial name
- vMII (NCT00604942)
- Testing
- Heller's Myotomy, Nissen Fundoplication, domperidone or esomeprazole (Conservative management)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Eosinophilic Esophagitis, Gastroesophageal Reflux
Phenotypic Characterization and Biomarkers Investigation for Eosinophilic Esophagitis in Pediatric Patients
The purpose of this study is to find out some potential biomarkers for the Eosinophilic Esophagitis (EoE) in pediatric patients through the prospective clinical characterization and assessment of samples collected during the…
- Trial name
- NCT03069573
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Uberlandia
Gastroesophageal Reflux Disease (GERD)
Medigus Ultrasonic Surgical Endostapler (MUSE) Registry
This registry is intended as an observational, post-marketing surveillance tool. The registry allows collection of baseline demographics and user experience of the commercially available MUSE system.
- Trial name
- NCT02366169
- Testing
- Medigus Ultrasonic Surgical Endostapler (MUSE) Procedure
- Where
- 16 sites in United States, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Medigus Ltd
Non-erosive Gastroesophageal Reflux Disease
Efficacy of TAK-438 Compared to Placebo in the Treatment of Non-Erosive Gastroesophageal Reflux Disease
The purpose of this study is to investigate the superiority of efficacy of TAK-438, once daily (QD), to placebo in patients with non-erosive gastroesophageal reflux disease.
- Trial name
- NCT01474369
- Testing
- TAK-438
- Where
- 52 sites in Japan
- Volunteers
- 827 people
- Sponsor
- Takeda
Gastroesophageal Reflux, Functional Dysphonia
Assessment on Effects of Tongjiang Granule in Treating Nonerosive Reflux Disease Overlapping Epigastric Pain Syndrome
Overlapping gastrointestinal symptoms of functional gastrointestinal diseases (FGIDs) is an internationally recognized problem in modern medical diagnosis and treatment.
- Trial name
- NCT05312463
- Testing
- Tongjiang granule, Tongjiang granule simulant
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Gastroesophageal Reflux Disease, Morbid Obesity
Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass
The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.
- Trial name
- NCT00951093
- Testing
- Gastric bypass
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinica Gastrobese
Gastroesophageal Reflux
MSG and Gastrointestinal Motility
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Trial name
- NCT01009658
- Testing
- Monosodium glutamate, Sodium chloride
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gunma University
Laryngopharyngeal Reflux
Efficacy and Safety of Alginos Oral Suspension to Treat Laryngopharyngeal Reflux
Laryngopharyngeal reflux (LPR), the backflow of gastric acid into the larynx and hypopharynx, is a contributing factor to hoarseness, throat clearing, throat pain, and globus sensation.
- Trial name
- NCT01450748
- Testing
- Sodium alginate
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- TTY Biopharm
Gastroesophageal Reflux Disease
Transoral Fundoplication Prior to Sleeve Gastrectomy Versus RNY Gastric Bypass on GERD Symptoms in Bariatric Patients
A retrospective and prospective cohort study to compare the effect of completing a Transoral Fundoplication procedure prior to Laparoscopic Sleeve Gastrectomy surgery to Laparoscopic Roux-en-Y Gastric Bypass in bariatric patients…
- Trial name
- NCT05365087
- Testing
- Transoral Fundoplication and Sleeve Gastrectomy, Gastric Bypass
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Lexington Health Incorporated
Gastroesophageal Reflux Disease
Stellate Ganglion Block on Gastroesophageal Reflux Disease
The goal of this clinical trial is to explore Clinical Effect of Stellate Ganglion Block on Gastroesophageal Reflux Disease. The main question it aims to answer is: Can stellate ganglion block improve gastroesophageal reflux…
- Trial name
- NCT06319521
- Testing
- Rehabilitation therapy, Stellate ganglion block, Lidocaine hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
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