Clinical trials: Gastroesophageal Reflux
Gastro Esophageal Reflux
Gastroesophageal Reflux Disease in the Dutch Population
Rationale: Screening for esophageal adenocarcinoma (EAC) precursors and treating them may help to decrease mortality of this malignancy.
- Trial name
- REFLUX (NCT05689918)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 4,719 people
- Sponsor
- Radboud University Medical Center
Gastroesophageal Reflux Disease
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of Pumosetrag in Patients With Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine if pumosetrag is effective in treating Gastroesophageal Reflux Disease (GERD) symptoms in patients who have a history of GERD symptoms and are currently taking an acid suppression…
- Trial name
- NCT01161602
- Testing
- Pumosetrag
- Where
- 5 sites in United States
- Sponsor
- Edusa Pharmaceuticals, Inc.
Laryngopharyngeal Reflux
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin
It is postulated that the incompetence of the upper esophageal sphincter (UES) to restrict passage of esophageal refluxate is fundamental to the development of LPR.
- Trial name
- NCT02552966
- Testing
- UESAD
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Gastroesophageal Reflux, Dyspepsia
Effects of Diet on Reflux and Dyspepsia
Reflux and dyspeptic symptoms are common affecting 10-20% of the population on a regular basis. Reflux symptoms such as heartburn and regurgitation are caused by the return of acid or non-acid gastric contents into the esophagus.
- Trial name
- NCT02425553
- Testing
- Diet
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gastroesophageal Reflux Disease, Laparoscopic Antireflux Surgery
Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized Trial
The aim of this study is to compare subjective and objective outcome and surgical "side effects" of Nissen and Toupet fundoplication performed in a single institution by only two surgeons and to compare pre and postoperative…
- Trial name
- NCT01321294
- Testing
- laparoscopic anti-reflux surgery
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Drug Interaction, GERD (Gastroesophageal Reflux Disease)
A Study to Investigate the Effect of Linaprazan Glurate on the Pharmacokinetics of Amoxicillin
This is an open, single arm, single-center Phase I trial designed to evaluate the effect of seven days repeated oral doses of linaprazan glurate on the pharmacokinetics (PK) of repeated doses of amoxicillin in healthy male and…
- Conditions
- Drug Interaction, GERD (Gastroesophageal Reflux Disease), Safety, and Tolerability
- Trial name
- NCT07308041
- Testing
- Drug Drug Interaction
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
GERD Gastroesophageal Reflux Disease
The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease
This study compares mechanical sphincter augmentation (LINX Reflux Management System) to double-dose proton pump inhibitors (PPIs) for the management of reflux symptoms related to gastroesophageal reflux disease (GERD).
- Trial name
- CALIBER (NCT02505945)
- Testing
- Omeprazole, LINX Reflux Management System
- Where
- 21 sites in United States
- Volunteers
- 152 people
- Sponsor
- Torax Medical Incorporated
Gastroesophageal Reflux
Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
After defining the manometric characteristics of UES incompetence associated with documented pharyngeal reflux, we will determine the reproducibility of manometric criteria for UES incompetence in prevention of pharyngeal reflux.
- Trial name
- SE-GERD (NCT05695846)
- Testing
- externally applied cricoid cartilage pressure
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Gastroesophageal Reflux Disease
A Retrospective Analysis of Patients With Gastroesophageal Reflux Disease Based on a Prospective Clinical Dataset
This retrospective, observational cohort study aimed to establish a comprehensive research cohort utilizing a large-scale prospective clinical registry.
- Trial name
- NCT07749989
- Testing
- Clinical Data Collection
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Friendship Hospital
Gastroesophageal Reflux Disease
Laparoscopic Total vs Partial Fundoplication in Patients With Atypical Symptoms of Gastroesophageal Reflux Disease
One hundred and twenty patients with documented extraesophageal symptoms of gastroesophageal reflux disease were randomized to either undergo floppy Nissen (n= 60) or Toupet fundoplication (n= 60).
- Trial name
- NCT05647668
- Testing
- Laparoscopic fundoplication
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Mykola Paranyak
Gastroesophageal Reflux
Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-339)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and esophagus. GERD occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the…
- Trial name
- NCT00163306
- Testing
- Pantoprazole
- Where
- 79 sites in Austria, Germany and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda
GERD in Children, GERD
The Study of Nutrition of Children and Adolescents With GERD
This trial is to study the aspects of nutrition in children and adolescents with GERD compared to the sex and age-matched control group
- Trial name
- NCT04202276
- Testing
- diet assessment
- Where
- Russia
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Gastric Reflux
Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients
A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.
- Trial name
- Gastric (NCT06687187)
- Testing
- Neostigmine
- Where
- Egypt
- Volunteers
- 3 people
- Sponsor
- Zulekha Hospitals
Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
The exact role of urinary tract infection in the appearance of chronic kidney disease is unclear. Children with congenital malformations of kidney and urinary tract have the higher risk of impairment of renal function.
- Conditions
- Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, Chronic Kidney Disease
- Trial name
- PREDICT (NCT02021006)
- Testing
- nitrofurantoin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 292 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Vesicoureteral Reflux, Urinary Tract Infections
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infecton, we evaluated the efficacy…
- Trial name
- RIVUR (NCT00405704)
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- 19 sites in United States
- Volunteers
- 607 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastroesophageal Reflux Disease
Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease
This study is to evaluate the safety and efficacy of radiofrequency energy procedure for Gastro-esophageal reflux disease (GERD) based on changes of symptoms, medication esophagitis grade, esophageal acid exposure and lower…
- Trial name
- NCT03223116
- Testing
- Radiofrequency delivery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
GERD
Gastroesophageal Reflux Disease Prospective Registry
The purpose of this registry is to evaluate information to determine which operations and treatments for gastroesophageal reflux disease or similar diseases of the stomach, esophagus or digestive tract are providing the most…
- Trial name
- GERD (NCT02479438)
- Testing
- Diagnosed with GERD
- Where
- United States
- Volunteers
- 744 people
- Sponsor
- Baylor Research Institute
Vesicoureteral Reflux
Prospective Pediatric Vesicoureteral Reflux Surgery Database
The purpose of this research is to provide a clearer understanding of quality and outcomes for three types of surgical procedures performed at Connecticut Children's for treatment of vesicoureteral reflux.
- Trial name
- NCT01373385
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Connecticut Children's Medical Center
Peptic Ulcer, Gastroesophageal Reflux
S-CEI of Nexium in Paediatric Patients
To capture safety and efficacy when Nexium are administered to pediatric patients in clinical practice after launch
- Trial name
- NCT03562026
- Where
- 31 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Patients With Persistent Objectified Gastroesophageal Reflux and Reflux-Associated Symptoms Despite PPI-Therapy With 40mg Esomeprazole
High Dosage Esomeprazole and Baclofen for Therapy of Gastroesophageal Reflux Disease
It has been reported that Baclofen is an appropriate tool in the therapeutic management of Gastroesophageal Reflux Disease. To objectify gastroesophageal reflux combined pH-metry/impedance monitoring was applied to patients with…
- Trial name
- NEXBAC (NCT00461604)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
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