Clinical trials: Gastroesophageal Reflux
GERD, Hiatal Hernia
Can EndoFLIP Improve Quality of Life Before and After Fundoplication?
Patients with reflux disease (heart burn), or a hiatal hernia, who do not get better with medication, may have surgery to help with their symptoms. Unfortunately, there is no agreed upon way to perform the surgery.
- Trial name
- NCT06159972
- Testing
- EndoFLIP
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Wiley Chung
Gastroesophageal Reflux Disease
Gastroesophageal Reflux Disease Diagnostic Trial
Gastroesophageal reflux disease (GERD) is a very common condition in clinical practice. In China, GERD affects nearly 150 million patients, whose quality of life are seriously impacted.
- Trial name
- GERDT (NCT06504134)
- Testing
- the Novel Esophageal Cell Collection Device
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Oesophageal Reflux, Gastric Reflux
Efficacy and Speed of Action of a Product to Control Gastric Hydration and Gastroesophageal Reflux
A Randomised, Placebo-Controlled Clinical Trial off the Efficacy and Rapidity of Action of a Product Containing Sodium Alginate, Calcium and Magnesium Salts, Hyaluronic Acid and Aloe Vera to Control Oesophageal-Gastric pH and…
- Conditions
- Oesophageal Reflux, Gastric Reflux, Hyperactivity; Stomach
- Trial name
- AQUAA (NCT05060744)
- Testing
- Antacid, Control
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Uriach Consumer Healthcare
Inflammation, Gastroesophageal Reflux
Trial to Assess the Effectiveness of Educational Outreach in Prescription Guidelines
Background: The Portuguese National Health Directorate has issued clinical practice guidelines on prescription of anti-inflammatory drugs and COX-2 inhibitors, acid suppressive therapy and proton pump inhibitors, and…
- Conditions
- Inflammation, Gastroesophageal Reflux, Gastrointestinal Diseases, Cardiovascular Diseases
- Trial name
- TEP (NCT01984034)
- Testing
- Educational Outreach Visits, Passive Dissemination
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Gastroesophageal Reflux Disease
The Effect of Lansoprazole in Combination With Ecabet Sodium for Gastroesophageal Reflux Disease
We will estimate the responses of lansoprazole and ecabet sodium combination therapy and compare with lansoprazole and placebo therapy in patients who need additional therapy after standard proton pump inhibitor treatment for…
- Trial name
- NCT01039558
- Testing
- ecabet sodium, lansoprazole
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Erosive Reflux Disease, Heartburn
Observationa Study is a Prospective and Multi-institutional Observational Study.
This observational study is a prospective, multi-institutional non intervention study to examine the prescription patterns, corresponding treatment effects and safety in routine clinical practice for patients prescribed for the…
- Conditions
- Erosive Reflux Disease, Heartburn, Acid Regurgitation
- Trial name
- NCT06952855
- Where
- South Korea
- Volunteers
- 5,536 people
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
GERD Gastroesophageal Reflux Disease, Laryngopharyngeal Reflux Disease
"The Voice of Reflux" - Backflow of Gastric Juice Leads to Irritation of the Vocal Folds: Are There Typical Differences in the Voice?
If gastric juice refluxes back into the oesophagus and up into the throat/pharynx/mouth area, causing discomfort or injury, this is known as reflux disease (reflux).
- Trial name
- NCT06495606
- Testing
- Voice sample; Recording with microphone + Questionnaire
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dental Erosion
Dental Erosion in Patients With Gastro-oesophageal Reflux
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
- Trial name
- NCT02775149
- Testing
- Collection of saliva samples, Visual detection of BEWE-index
- Volunteers
- 30 people
- Sponsor
- University of Göttingen
Gastroesophageal Reflux Disease
PH Metry Study to Compare the Antacid Activity of Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects
Primary Objective: Pharmacodynamics: assessment by pH metry of the change in gastric pH (antacid activity) of Z0063, in comparison to the effect of Gaviscon Double Action Tablets, in healthy adult subjects.
- Trial name
- NCT03069963
- Testing
- Z0063, Gaviscon
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sanofi
Asthma, Gastroesophageal Reflux Disease
Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.
The hypothesis for this study is that potent anti-secretory therapy with high dose PPI improves asthma control regardless of either asthma severity or the presence of GERD symptoms.
- Trial name
- NCT00214552
- Testing
- rabeprazole
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Associated Scientists to Help Minimize Allergies
Laryngopharyngeal Reflux Symptoms, Laryngopharyngitis Chronic
Kazakh Version of Reflux Symptom Index
Reflux symptoms index (RSI) were developed to identify a clinical index of suspicion for laryngopharyngeal reflux (LPR) in patients with ear, nose, and throat symptoms.
- Conditions
- Laryngopharyngeal Reflux Symptoms, Laryngopharyngitis Chronic, Gastro Esophageal Reflux Disease
- Trial name
- NCT05296655
- Testing
- Reflux Symptom Index Inventory (diagnostic survey), Reflux finding score
- Where
- 2 sites in Kazakhstan
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Kazakh Medical University of Continuing Education
Refractory Reflux Esophagitis
Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole
The research aims to investigate whether trimebutine maleate combined with rabeprazole can improve the clinical efficacy in patients With refractory Los Angeles grade A or B reflux esophagitis .
- Trial name
- rRE (NCT02986685)
- Testing
- Trimebutine Maleate, rabeprazole
- Where
- China
- Sponsor
- Xijing Hospital of Digestive Diseases
Venous Leg Ulcer
A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers
The objective of this study is to assess the efficacy and safety of VitroGro® combined with standard care in the treatment of Venous Leg Ulcers (VLUs) compared to Placebo with standard care over the course of the 8-week treatment…
- Trial name
- NCT01982318
- Testing
- VitroGro® ECM, Dulbecco's Phosphate Buffered Saline
- Sponsor
- Tissue Therapies Ltd.
Extra-esophageal Reflux
Sleep Position May Reduce Acid Reflux Symptoms at Night
This study is designed to determine if the addition of the MedclineTM Sleep Assist Device will decrease night-time gastroesophageal reflux disease events.
- Trial name
- NCT02320968
- Testing
- MedclineTM Sleep Assist Pillow
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Gastroesophageal Reflux
Anti Reflux Mucosal Ablation Therapy in PPI Dependent GERD
This is a prospective, randomized, single-blinded, interventional, controlled trial to evaluate the efficacy and safety of endoscopic anti reflux mucosal ablation (ARMA) in PPI dependent gastroesophageal reflux disease (GERD) in…
- Trial name
- APDG (NCT05763485)
- Testing
- Anti reflux mucosal ablation (ARMA)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Pediatric Obesity, NAFLD
Effect of Obesity on Proton Pump Inhibitors
This longitudinal study tests the hypothesis that obesity affects drug pharmacology of acid suppression medications in children.
- Conditions
- Pediatric Obesity, NAFLD, GERD
- Trial name
- LiverLabPPI (NCT04248335)
- Testing
- Lansoprazole, Pantoprazole, Midazolam
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Gastroesophageal Reflux
Efficacy of Dexlansoprazole MR on Heartburn Control in Participants Previously Receiving Twice Daily Proton Pump Inhibitor Therapy
The purpose of this study is to determine if patients with well-controlled heartburn symptoms on twice-daily proton pump inhibitor therapy remain well-controlled after stepping down to once-daily (QD) dexlansoprazole modified…
- Trial name
- NCT00847808
- Testing
- Dexlansoprazole MR QD
- Where
- 52 sites in United States
- Volunteers
- 178 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesophageal Reflux Disease (GERD) May Experience
The purpose of the study is to estimate what effect 4 different doses of AZD3355 will have on the number of reflux episodes, in patients who have GERD and still experience symptoms despite proton pump inhibitor (PPI) treatment.
- Trial name
- NCT01043185
- Testing
- AZD3355
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
GERD, Proton Pump Inhibitor
An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan
Dexlansoprazole modified release (MR), the R-enantiomer of Lansoprazole, is an FDA approved drug (2009) for the management of erosive esophagitis and nonerosive reflux disease 1.
- Trial name
- NCT03079050
- Testing
- Dexlansoprazole 60 MG
- Where
- Lebanon
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
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