Clinical trials: Gastroesophageal Reflux
Gastroesophageal Reflux (GER), Infants
Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux
The goal of this clinical trial is to evaluate efficacy and safety of Zinc-L carnosine/Polaprezinc in infants with GER. Researchers will compare Zinc-L carnosine/Polaprezinc to a placebo (a look-alike substance that contains no…
- Trial name
- GER (NCT06678997)
- Testing
- Zinc-L carnosine/Polaprezinc, Thickened formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Obesity
Esophageal Manometry and Impedance Study in Obese Patients Before and During Anesthesia
The purpose of this study is to evaluate the effects of anesthesia on the esophageal body in obese patients before and during anesthesia.
- Trial name
- NCT01703897
- Testing
- Manometry and Impedance analysis
- Where
- Sweden
- Sponsor
- Örebro University, Sweden
Erosive Esophagitis
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
The aim of the study is to compare the safety and efficacy of two doses of Nexium in maintaining healing of erosive esophagitis in patients 1 to 11 years of age.
- Trial name
- EE (NCT05267613)
- Testing
- Nexium 20mg, Nexium 10mg
- Where
- 41 sites in United States, Argentina and 8 more
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
GERD
Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients
Researchers are trying to determine if abdominal breathing exercises can reduce symptoms associated with GERD (Gastroesophageal reflux disease).
- Trial name
- NCT04120025
- Testing
- Diaphragm Training
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux
Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
After defining the manometric characteristics of UES incompetence associated with documented pharyngeal reflux, we will determine the reproducibility of manometric criteria for UES incompetence in prevention of pharyngeal reflux.
- Trial name
- SE-GERD (NCT05695846)
- Testing
- externally applied cricoid cartilage pressure
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Pancreaticobiliary Reflux
Pancreaticobiliary Reflux in Patients Without Cholelithiasis
Pancreaticobiliary reflux has been found in patients with cholelithiasis and gallbladder cancer associated with normal pancreaticobiliary union.
- Trial name
- NCT00890201
- Testing
- Gallbladder bile sampling and intraoperative cholangiography
- Where
- Chile
- Volunteers
- 197 people
- Sponsor
- Cirujanos la Serena
Infantile Colic, Gastroesophageal Reflux (GER)
BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months
Infants often experience functional gastrointestinal symptoms (e.g., colic, excessive gas, regurgitation, constipation, or loose stools) that distress families and may reflect an imbalance of the gut microbiome.
- Conditions
- Infantile Colic, Gastroesophageal Reflux (GER), Functional Constipation, Functional Diarrhea
- Trial name
- CTBE2503 (NCT07148583)
- Testing
- BioAmicus Complete, Usual Care (No Probiotic)
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Gastroesophageal Reflux Disease (GERD)
Safety and Efficacy of AST-120 in Patients With GERD Who Continue to be Symptomatic on a Standard Dose of PPI
The purpose of this project is to test how safe and how well AST-120, an investigational product, works in treating too much acid in the stomach.
- Trial name
- NCT00587275
- Testing
- AST-120, Celphere CP-305
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ocera Therapeutics
GERD
A Study to Evaluate the Efficacy and Safety of Controlled Release Arbaclofen Placarbil (XP19986) in Patients With Gastroesophageal Reflux Disease
The purpose of the study is to evaluate the efficacy and safety of arbaclofen placarbil (XP19986) compared to placebo in patients with gastroesophageal reflux disease.
- Trial name
- NCT00838396
- Testing
- XP19986 CR
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- Indivior Inc.
Gastroesophageal Reflux
Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in South Korea
The purpose of this study is to examine the treatment profile of approximately 1,000 adult patients with gastroesophageal reflux who begin raberpazole sodium treatment for 4 months, and assess patients' adherence to the study…
- Trial name
- NCT01018160
- Testing
- Rabeprazole Sodium
- Volunteers
- 1,197 people
- Sponsor
- Janssen Korea, Ltd., Korea
Heartburn, Dyspepsia
Primary carE PPi dEprescRibing Trial
Proton pump inibitors (PPIs) is a class of medications that reduce the acid secretion in the stomach. These medications are very effective to relieve symptoms of acid reflux for a well-identified group of diseases and conditions.
- Conditions
- Heartburn, Dyspepsia, Reflux
- Trial name
- PEPPER (NCT05629143)
- Testing
- de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate
- Where
- Belgium
- Volunteers
- 724 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
This study will test the hypothesis that treatment with laparoscopic anti-reflux surgery in subjects with idiopathic pulmonary fibrosis (IPF) and abnormal gastroesophageal reflux (GER) will slow the decline of forced vital…
- Trial name
- WRAP-IPF (NCT01982968)
- Testing
- Surgery
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Gastro Esophageal Reflux
Validation of HRM Score for the GERD Diagnosis
The goal of this prospective study is to validate a high resolution manometry score to predict pathologic GERD in patients with reflux symptoms.
- Trial name
- HRM nomogram (NCT05851482)
- Testing
- High resolution manometry
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- IRCCS Policlinico S. Donato
Gastroesophageal Reflux Disease
Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease
The purpose of this study is to evaluate the effectiveness of symptom control in gastroesophageal reflux disease (GERD) participants following treatment with dexlansoprazole.
- Trial name
- NCT02351960
- Testing
- Dexlansoprazole
- Where
- 10 sites in Hong Kong, South Korea and 1 more
- Volunteers
- 296 people
- Sponsor
- Takeda
Gastroesophageal Reflux
Hyaluronic Acid in Patients With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) remains one of the most common pathologies seen among gastroenterologists, surgeons, and primary care physicians.
- Trial name
- NCT05561179
- Testing
- Hyaluronic acid injection, Sodium chloride injection (control group)
- Where
- Ecuador
- Volunteers
- 120 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Gastroesophageal Reflux
Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.
- Trial name
- NCT05556824
- Testing
- MHS-1031
- Where
- 18 sites in United States
- Volunteers
- 255 people
- Sponsor
- Microbiome Health Sciences
Chest Pain, Gastroesophageal Reflux
Chest Pain Pilot Study
The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.
- Trial name
- NCT00251901
- Testing
- Esomeprazole
- Where
- 80 sites in Canada, Denmark and 4 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Barrett's Esophagus, GERD
Cytosponge Adequacy Study Evaluation II
This study will assess the Minimally Invasive Esophageal Cytology Collection System in Patients with Barrett's Esophagus or GERD Symptoms.
- Trial name
- CASEII (NCT02395471)
- Testing
- Cytosponge™ Cell Collection Device
- Where
- 5 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastro Esophageal Reflux
Effect of a Combination Oral Formulation of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate in Patients With Gastro-Esophageal Reflux Disease Not Fully Satisfied With Their Treatment
This is a post-market, multi-center, double-blind, placebo-controlled, randomized, cross-over study with GERDOff Plus added on top of the current PPI treatment in patients with GERD.
- Trial name
- NCT04202692
- Testing
- Hyaluronic acid with chondroitin sulphate and magnesium trisilicate, 1100 mg melt in mouth tablet
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- SOFAR S.p.A.
Varicose Veins, Chronic Venous Disorder
First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebectomy
Investigators hypothesize that first class compression therapy during the postoperative period will improve patient adherence due to easier application and reduced discomfort.
- Conditions
- Varicose Veins, Chronic Venous Disorder, Chronic Venous Insufficiency (CVI), Venous Reflux
- Trial name
- FISCHER (NCT06913764)
- Testing
- class I compression stockings of the RAL-GZ 387 standard: 1 month using, class II compression stockings of the RAL-GZ 387 standard: 1 month using
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Moscow City Hospital named after A.K. Eramishantsev
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