Clinical trials: Gastroesophageal Reflux in Children
Eosinophilic Esophagitis
Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies
The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.
- Trial name
- NCT02038894
- Testing
- Intubated with Sevoflurane (IS), Intubated with Propofol (IP), Zofran - no intubation
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bone Turnover Rate Disorder, Calcium Metabolism Disorders
Effects of Lansoprazole on Bone Turnover Markers
Use of proton pump inhibitors (PPI) has increased in recent years. There are concerns that PPIs have possible negative effects on bone metabolism.
- Trial name
- NCT04814316
- Testing
- Blood and urine specimens
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Vesicoureteral Reflux
Midazolam Effect in Children Undergoing Voiding Cystourethrogram (VCUG)
The purpose of this research is to validate the common administration of oral midazolam to children prior to voiding cystourethrogram (VCUG) to see if this will significantly decrease children's anxiety and make the experience…
- Trial name
- NCT00894465
- Testing
- midazolam
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Vesicoureteral Reflux (VUR), Urinary Tract Infection
Polyacrylate Polyalcohol Copolymer for Vesicoureteral Reflux
Endoscopic correction of VUR has gained its popularity due to its less invasiveness, associated low morbidity and short hospital stay.
- Trial name
- NCT01926353
- Where
- Philippines
- Volunteers
- 25 people
- Sponsor
- St. Luke's Medical Center, Philippines
Otitis Media With Effusion
Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children
The accumulation of fluid behind the ear drum without any acute inflammation is known as otitis media with effusion (OME). It is the most common cause of acquired hearing loss during childhood.
- Trial name
- NCT01082029
- Testing
- Lansoprazole
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Hamilton Health Sciences Corporation
Gastroesophageal Reflux
Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ?
The aim of the study was to compare short- and longterm outcomes after laparoscopic and open Nissen fundoplication in children.
- Trial name
- NCT01551134
- Testing
- Fundoplication
- Where
- Norway
- Volunteers
- 88 people
- Sponsor
- Oslo University Hospital
Autism, Gastrointestinal Symptoms
A Study to Assess the Role of a Gluten Free-dairy Free (GFCF) Diet in the Dietary Management of Autism Associated Gastrointestinal Disorders
Doctors at MassGeneral Hospital for Children (MGHfC) are doing a research study to learn if a gluten free-dairy free (GFCF) diet is helpful in improving gastrointestinal symptoms associated with autism.
- Trial name
- GFCF (NCT01116388)
- Testing
- GFCF product with GFCF diet, product containing gluten and casein (milk protein) with GFCF diet
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Otitis Media With Effusion, Laryngopharyngeal Reflux
Three Methods Used in the Diagnosis of EER in Children With OME
Detection of extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME) using three different diagnostic methods and selection of the group of patients with severe EER who could potentially benefit…
- Trial name
- NCT02183961
- Testing
- Restech, Peptest, Detection of pepsin in adenoid specimen
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- University Hospital Ostrava
Pediatric Obesity, NAFLD
Effect of Obesity on Proton Pump Inhibitors
This longitudinal study tests the hypothesis that obesity affects drug pharmacology of acid suppression medications in children.
- Conditions
- Pediatric Obesity, NAFLD, GERD
- Trial name
- LiverLabPPI (NCT04248335)
- Testing
- Lansoprazole, Pantoprazole, Midazolam
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children
Laparoscopic fundoplication is increasingly performed in paediatric surgery. Many types of fundoplication are performed, each has advantages and disadvantages.
- Trial name
- NCT01027975
- Testing
- laparoscopic Nissen/laparoscopic Thal
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Vesico-Ureteral Reflux, Filum Terminale Lipoma
Effects of Parental Holding on Pain Response in Young Children During Cystometry
Cystometry is essential for diagnosis and treatment plans by identifying the causes of lower urinary tract symptoms and objectively evaluating bladder functions in diseases such as neurogenic bladder, voiding dysfunction, and…
- Trial name
- NCT05864131
- Testing
- Lying, Holding
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Yonsei University
Gastroesophageal Reflux
Randomized Trial for Pharmacogenomics-based Proton Pump Inhibitor Therapy in Children
Proton pump inhibitors are administered to children as off-label use in Japan. The purpose of this study is to evaluate the effects of CYP2C19 genotypes on pharmacokinetic /pharmacodynamic profiles of PPI in children.
- Trial name
- NCT00299845
- Testing
- Lansoprazole
- Where
- Japan
- Sponsor
- Osaka University
Erosive Esophagitis, Heartburn
A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring
The main objective of the study is to compare the maternal, fetal, and infant outcomes of pregnant women who are exposed to vonoprazan during pregnancy with outcomes of an internal comparison cohort of pregnant women who are…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Non-erosive Gastroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06660342
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Vesico-Ureteral Reflux
A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children
Vesicoureteral reflux (VUR) is the most common urologic diagnosis in neonates estimated at 1% of newborns, and 30-45% of the children who present with urinary tract infection (1).
- Trial name
- NCT02271035
- Testing
- Deflux, Vantris
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Erosive Esophagitis
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
The aim of the study is to compare the safety and efficacy of two doses of Nexium in maintaining healing of erosive esophagitis in patients 1 to 11 years of age.
- Trial name
- EE (NCT05267613)
- Testing
- Nexium 20mg, Nexium 10mg
- Where
- 41 sites in United States, Argentina and 8 more
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
VUR - Vesicoureteric Reflux
Diagnosing Vesicoureteric Reflux in Children by Direct Isotope Cystography and Contrast Enhanced Voiding Ultrasonography
The purpose of this study is to examine the applicability of contrast enhanced voiding ultrasonography in diagnosing vesicoureteral reflux (VUR) in pediatric patients compared to direct isotope cystography.
- Trial name
- NCT06138080
- Testing
- Contrast-enhanced voiding ultrasonography (CEVUS), Direct isotope cystography
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Gastroesophageal Reflux
Study Evaluating Pantoprazole in Children With Gastroesophageal Reflux Disease (GERD)
To evaluate the clinical outcomes of treatment with oral pantoprazole in children 1 through 5 years of age with endoscopically proven symptomatic GERD.
- Trial name
- NCT00300755
- Testing
- pantoprazole sodium enteric-coated spheroid
- Where
- 43 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Diabetes, Diabetes Mellitus, Type 1
Comparison of 2 NovoFine® Needles on the Reflux of Insulin
This trial is conducted in Europe. This trial aims to ensure that there is no substantial clinically relevant difference between the two Novo Nordisk needles NovoFine® 6 x 0.30 mm and NovoFine® 8 x 0.30 mm on reflux of insulin…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Delivery Systems
- Trial name
- NCT00872560
- Testing
- NovoFine® needle 6 mm, NovoFine® needle 8 mm
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Novo Nordisk A/S
Vesico-Ureteral Reflux
CeVUS With Intravesical Administration of OPTISON TM (Trademark) in Children
In this clinical trial the investigators aim to evaluate the diagnostic feasibility and safety of ceVUS with the intravesical use of OPTISON for vesicoureteral reflux detection and urethral imaging in children.
- Trial name
- ceVUS (NCT02204917)
- Testing
- OPTISON
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kassa Darge
Gastroesophageal Reflux Disease
PK Study With Pantoprazole in Obese Children and Adolescents
Multicenter, comparative single-dose pharmacokinetic (PK) study
- Trial name
- PAN01 (NCT02186652)
- Testing
- Pantoprazole
- Where
- 4 sites in United States
- Volunteers
- 41 people
- Sponsor
- Phillip Brian Smith