Clinical trials: Gastrointestinal Bleed
Surgical Hemorrhage, Liver Cancer
VALIDATION OF THE VIBe INTRAOPERATIVE BLEEDING SCALE IN LIVER SURGERY
Surgical hemostasis has become one of the fundamental principles for the advancement of surgery. The use of hemostatic agents is standard in many surgical specialties, although the lack of consensus or standardized…
- Conditions
- Surgical Hemorrhage, Liver Cancer, Liver Metastases
- Trial name
- NCT05369988
- Where
- 2 sites in Spain
- Volunteers
- 259 people
- Sponsor
- Hospital Miguel Servet
Hemorrhage, Esophageal Varices
Short Course Terlipressin for Control of Acute Variceal Bleeding
The purpose of this study is to determine whether 24 hours of Terlipressin is as effective as 72 hours of Terlipressin in preventing re-bleed once esophageal variceal bleed has been controlled with endoscopic therapy (variceal…
- Conditions
- Hemorrhage, Esophageal Varices, Portal Hypertension
- Trial name
- NCT00369694
- Testing
- Terlipressin, Terlipressin & then Dummy
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Aga Khan University
Portal Hypertension
Multimodal Ultrasound and Portal Hypertension
According to international guidelines, Hepatic Venous Pressure Gradient is the gold standard technique for portal hypertension measurement, but it is invasive and poorly available.
- Trial name
- NCT05789641
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Neoplasm
Ultra-sensitivity Quantitative Fecal Immunochemical Test in Detecting Colorectal Advanced Adenoma and Colorectal Cancer
Early detecting and removing of colorectal advanced adenomas can reduce the incidence of colorectal cancer. Because of the less bleeding of advanced adenomas, sensitivities of the common used quantitative fecal immunochemical…
- Trial name
- NCT04856423
- Testing
- The us-qFIT and colonoscopy with pathological examination
- Where
- 6 sites in China
- Volunteers
- 6,000 people
- Sponsor
- Shandong University
Liver Diseases, Liver Cirrhosis
Intraoperative Phlebotomies and Bleeding in Liver Transplantation
Liver transplantation are surgeries associated with important bleeding and often require perioperative red blood cell (RBC) transfusions.
- Conditions
- Liver Diseases, Liver Cirrhosis, Surgery, Surgery--Complications
- Trial name
- TOF_PHLEBO (NCT04826666)
- Where
- Canada
- Volunteers
- 679 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Carcinoma (CRC), Right Hemicolectomy
The Intraoperative Technical Errors of Robotic vs. Laparoscopic Radical Right Hemiclectomy
Experimental design: This study is a multicenter, prospective, randomized, controlled phase III clinical trial that identifies, classifies, defines, and quantitatively analyzes technical errors between robotic and laparoscopic…
- Trial name
- NCT07138859
- Testing
- Robot assisted radical right hemicolectomy (D3 lymph node dissection), Laparoscopic assisted radical right hemicolectomy (D3 lymph node dissection)
- Where
- China
- Volunteers
- 368 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Purpura, Thrombocytopenic, Idiopathic and Hepatitis C
Eltrombopag Phase III Study In Chinese Chronic ITP Patients
This randomized, double-blind and open-label phase III study aimed to determine the efficacy, tolerance and safety of eltrombopag in Chinese chronic primary immune thrombocytopenia (ITP) adult subjects.
- Trial name
- NCT01762761
- Testing
- eltrombopag
- Where
- 18 sites in China
- Volunteers
- 155 people
- Sponsor
- Novartis Pharmaceuticals
Gastrointestinal Hemorrhage, Variceal Bleeding
Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy
Patients with liver cirrhoses and recent history of variceal bleeding, with HVPG documented non response to medical therapy with non selective beta blockers +/- mononitrates or variceal rebleeding during adequate medical therapy…
- Conditions
- Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis, Encephalopathy
- Trial name
- ENDOvsTIPS (NCT00570973)
- Testing
- endoscopic band ligation, TIPS-Implantation
- Where
- 4 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Non-variceal Upper Gastrointestinal Bleeding
Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.
- Trial name
- NCT03980496
- Testing
- Omeprazole
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Bialystok
Portal Hypertension
Standard Therapy and TIPS for Moderate to High-risk Esophageal and Gastric Variceal Bleeding
Comparison of endoscopic therapy combined with non-selective therapy β Receptor blockers (NSBBs) and TIPS in the treatment of liver cirrhosis The impact of reducing bleeding on the survival of critically ill patients.
- Trial name
- NCT06013670
- Testing
- Endoscopy+NSBBs, Transjugular intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Gastrointestinal Hemorrhage, Clostridium Difficile Colitis
Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.
study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI…
- Trial name
- NCT01477320
- Testing
- Pantoprazole 40 mg IV daily and tube feed.
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Mohamed Saad
End Stage Liver DIsease, Liver Transplant; Complications
Fibrinogen and Intraoperative Bleeding in Liver Transplant
Liver transplantation is the only treatment for end-stage liver disease. It is a high-risk surgery that can cause heavy intraoperative bleeding.
- Trial name
- FIB_TOF (NCT04925843)
- Where
- Canada
- Volunteers
- 612 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Peptic Ulcer Hemorrhage
IIaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients
The purpose of this study is to compare the efficacy and safety of ilaprazole and omeprazole in the treatment and prevention of peptic ulcer bleeding.
- Trial name
- NCT03362268
- Testing
- Ilaprazole, omeprazole
- Volunteers
- 180 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Intracerebral Hemorrhage
Clinical Outcomes Following Parafascicular Surgical Evacuation of Intracerebral Hemorrhage: A Pilot Study
This study is determining the clinical outcomes, based on neurological testing, for the parafascicular minimally invasive clot evacuation technique. We will collect data from the time of surgery up until 90 days post procedure.
- Trial name
- MISPACE (NCT01971359)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Hepatic Encephalopathy
Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding
The aim of this study is to determine whether lactulose, L-ornithine L-aspartate, and rifaximin are effective in the prevention of the development of hepatic encephalopathy in cirrhotic patients with acute variceal bleeding
- Trial name
- NCT02158182
- Testing
- Lactulose, L-ornithine L-aspartate, Rifaximin
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Hospital General de Mexico
Gastrointestinal Bleeding
Uninterrupted Clopidogrel Therapy Before Elective Colonoscopy Will Increase the Risk of Post-polypectomy Bleeding
This double-blind, randomized trial aims to evaluate whether uninterrupted anti-platelet therapy (clopidogrel) will increase the risk of bleeding associated with removal of polyp during colonoscopy in patients with coronary…
- Trial name
- NCT01806090
- Testing
- clopidogrel
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Choledocholithiasis, Endoscopy
Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone
Using a needle knife papillotome by an experienced endoscopist, endoscopic sphincterotomies were performed in difficult cannulation cases.
- Trial name
- NCT00173368
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Liver Cirrhosis, Gastroesophageal Varices Bleeding
Comparison of Underdilated Versus Standard TIPS in Preventing Variceal Rebleeding in Patients With Cirrhosis
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention for complications of portal hypertension.
- Trial name
- UVR-TIPS (NCT07253389)
- Testing
- Underdilated TIPS, Standard TIPS
- Where
- China
- Volunteers
- 648 people
- Sponsor
- Air Force Military Medical University, China
Decompensated Cirrhosis, Bleeding Varices
Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis
The purpose of this study is to determine whether early use of transjugular intrahepatic portosystemic shunt (TIPS) with Polytetrafluoroethylene (PTFE) covered stents is able to prolong the survival in patients with advanced…
- Trial name
- NCT01370161
- Testing
- TIPS treatment, Medical treatment
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Air Force Military Medical University, China