Clinical trials: Gastrointestinal Bleed
Liver Tumor; Surgery, Primary Liver Tumor, Metastatic Liver
Stroke Volume Variation Versus Central Venous Pressure Guidance for Reducing Perioperative Blood Loss During Open Liver Resection, A Non-inferiority Randomized Controlled Trial
Liver resection is a major surgery that can be associated with significant intraoperative blood loss and blood transfusion. Among high-volume centers, median intraoperative blood loss ranges between 300-800 ml.
- Conditions
- Liver Tumor; Surgery, Primary Liver Tumor, Metastatic Liver, Primary Liver Cancer, Liver Resection
- Trial name
- NCT06905015
- Testing
- High SVV-guided fluid management, Low CVP-guided fluid management
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Chiang Mai University
Liver Cirrhosis, Gastroesophageal Varices
Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography
Through the parameters of liver stiffness and spleen stiffness obtained by combi-elastography technique, summarize and analyze the warning index of esophagogastric variceal bleeding in patients with cirrhosis, so as to provide a…
- Conditions
- Liver Cirrhosis, Gastroesophageal Varices, Variceal Hemorrhage
- Trial name
- NCT04640350
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Coronary Heart Disease, Acute Coronary Syndrome
Cohort Study of Clopidogrel and Proton Pump Inhibitors
Patients who have experienced and survived non-ST segment elevation acute coronary syndromes are often prescribed a combination of aspirin and clopidogrel to thin the blood and prevent further acute coronary episodes.
- Conditions
- Coronary Heart Disease, Acute Coronary Syndrome, Drug Interactions, Clopidogrel
- Trial name
- NCT01231867
- Where
- United Kingdom
- Volunteers
- 24,471 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Upper GI Bleeding, Bleeds Gastric
Metoclopramide in Upper Gastrointestinal Bleed
The goal of this clinical trial is to test if metoclopramide can improve effectiveness of endoscopic intervention in upper gastrointestinal (GI) bleeds.
- Conditions
- Upper GI Bleeding, Bleeds Gastric, Bleed Ulcer, Hemorrhage Gastric
- Trial name
- NCT05746377
- Testing
- Metoclopramide 10mg, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mercy Health System
Upper Gastrointestinal Bleed
Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed
Despite recommendations from clinical practice guidelines to discharge patients from the hospital on once daily proton pump inhibitors after acute management of UGIB, clinical practice is to use twice daily proton pump inhibitor…
- Trial name
- NCT02235311
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Missouri-Columbia
Peptic Ulcers, Upper Gastrointestinal Bleeding
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Trial name
- NCT00374101
- Testing
- omeprazole, pantoprazole
- Where
- 10 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Bleeding Peptic Ulcer
Oral Omeprazole in Bleeding Peptic Ulcer
Find out if there is a significant difference between clinical outcome among the patients with bleeding peptic ulcer treated with oral omeprazole compared to those treated with intravenous omeprazole.
- Trial name
- NCT04170270
- Testing
- Omeprazole
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tumor of Pancreas, Surgical Blood Loss
Enucleation of Pancreatic Tumor by Blocking Abdominal Trunk and Superior Mesenteric Artery
Pancreatic enucleation could preserve more healthy pancreatic tissues and functions with a low recurrence risk. However, conventional enucleation can cause significant intraoperative bleeding, especially in which tumors in the…
- Trial name
- NCT06164769
- Testing
- blocking both the abdominal trunk and superior mesenteric artery in the pancreatic enucleation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Gastrointestinal Bleeding
Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents
The goal of this clinical trial is to evaluate the clinical efficacy and safety of YiWei Jiaohuang Ointment in treating gastrointestinal bleeding associated with oral antithrombotic therapy.
- Trial name
- NCT07339956
- Testing
- A Chinese herb formula--Yiwei Jiaohuang Onitment, Rabeprazole Enteric-Coated Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Patient Compliance
Lactate Level and Gastrointestinal Bleeding
Acute gastrointestinal bleeding is a common emergency with significant morbidity, mortality, and cost. Appropriate risk stratification of patients presenting with acute gastrointestinal bleeding aids in the triage of patients to…
- Trial name
- NCT04104425
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Assiut University
Dysphagia Following Cerebrovascular Accident
Effect of Home Based Swallowing Exercise in Stroke Patients With Dysphagia
Dysphagia is a common problem in post-stroke patients and greatly impaired quality of life. Among them, the strength of tongue and lip muscles played a key role in the oral phase of swallowing and many stroke survivors suffered…
- Trial name
- NCT05758350
- Testing
- home based IOPI swallow training
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Bleeding Peptic Ulcer
Over-the-scope Clip Versus Through-the-scope Clip for Endoscopic Hemostasis of High Risk Bleeding Peptic Ulcers
To compare in a multicenter, prospective, randomized, controlled trial the efficacy and safety of OTSC versus TTS clip for first-line hemostasis of high risk bleeding peptic ulcers
- Trial name
- OTSCvsTTS (NCT03551262)
- Testing
- OTSC, TTS clip
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda USL Modena
Gastrointestinal Hemorrhage
Predictive Role of Red Cell Distribution Width in Upper GI Bleeding Patients
Acute upper-gastrointestinal bleeding (UGIB) is a commonly encountered cause of admission in emergency department (ED). Early risk stratification allows appropriate therapy that may be helpful to advance the patient's morbidity…
- Trial name
- NCT03119987
- Testing
- Red cell distribution widths
- Volunteers
- 400 people
- Sponsor
- Konkuk University Medical Center
Enteral Nutrition, Gastro Intestinal Bleeding
Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled Trial
Enteral nutrition can provides prophylaxis against stress ulcer bleeding in critically ill patients and there may be no need to use acid suppressing drugs for stress ulcer bleeding prophylaxis in these patients.
- Conditions
- Enteral Nutrition, Gastro Intestinal Bleeding, Stress Ulcer Prophylaxis, Proton Pump Inhibitor
- Trial name
- NCT03098537
- Testing
- enteral nutrition + proton pump inhibitor, enteral nutrition only
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- TC Erciyes University
Gastrointestinal Bleeding, Antiplatelet Therapy
MCE Identifying Bleeding Lesions in Patients with Antiplatelet Drugs-Related Acute Non-Hematochezia Gastrointestinal Bleeding
The goal of this clinical trial is to explore the diagnostic efficacy of detachable string magnetically controlled capsule endoscopy (ds-MCE) for identification of bleeding lesions in patients with antiplatelet drugs-related…
- Trial name
- MCE (NCT06698874)
- Testing
- ds-MCE and EGD examinations
- Where
- 4 sites in China
- Volunteers
- 204 people
- Sponsor
- Changhai Hospital
Liver Cirrhosis
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
A feasibility trial called PROFIT has previously shown that FMT administered endoscopically into the jejunum in patients with cirrhosis is safe and feasible and have identified some potential mechanisms of action that warrant…
- Trial name
- PROMISE (NCT06461208)
- Testing
- Encapsulated FMT
- Where
- 23 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College London
Adverse Reaction to Drugs Affecting the Gastrointestinal System
ELIGIBLE (Efficacy of Left atrIal Appendage Closure After GastroIntestinal BLEeding)
Patients with atrial fibrillation requiring anticoagulation treatment are at high risk of gastrointestinal bleeding. The investigators propose the percutaneous stop the oral anticoagulation and closure of the left atrial…
- Trial name
- ELIGIBLE (NCT01628068)
- Testing
- Left atrial appendage occlusion
- Where
- 6 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Liver Neoplasms, Liver Cirrhosis
Infrahepatic Inferior Vena Cava Clamping Versus Selective Hepatic Vascular Exclusion Involving the Portal Triad Clamping
This clinical trial aims to compare infrahepatic inferior vena cava clamping (IIVCC) with selective hepatic vascular exclusion (SHVE) involving the portal triad clamping (PTC) in complex cirrhotic liver resection.
- Trial name
- NCT02405416
- Testing
- Infrahepatic inferior vena cava clamping, Selective hepatic vascular exclusion, Portal triad clamping
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology