Clinical trials: Gastrointestinal Bleed
Gastric Polyp, Gastric Neoplasm
Tranexamic Acid During Upper GI Endoscopic Resection Procedures
Endoscopic resection of gastrointestinal lesions may prevent cancer. However, resection is associated with adverse events such as bleeding.
- Conditions
- Gastric Polyp, Gastric Neoplasm, Duodenal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT05688020
- Testing
- Tranexamic acid, Epinephrine injection
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Hemorrhoids, Bleeding
Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrhoids
The investigators aim at prospectively comparing procedural pain, adverse events and rebleeding rates of anoscopic rubber band ligation and endoscopic hypertonic saline injection in patients with symptomatic hemorrhoidal disease
- Conditions
- Hemorrhoids, Bleeding, Pain
- Trial name
- NCT02851940
- Testing
- Rubber Band Ligation, Hypertonic Saline Infusion
- Where
- Lebanon
- Sponsor
- American University of Beirut Medical Center
Chronic Radiation Proctitis, Rectal Bleeding
Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study
Refractory rectal bleeding of chronic radiation proctitis (CRP) is still problematic and does not respond to medical treatments including reagents, endoscopic argon plasma coagulation (APC) or topical formalin.
- Conditions
- Chronic Radiation Proctitis, Rectal Bleeding, Colostomy Stoma, Anemia
- Trial name
- NCT03397901
- Testing
- Transverse colostomy
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Bloody Stool, Necrotizing Enterocolitis
a Clinical Risk Score to Predict Bloody Stool in Neonates
Bloody stool is a main focus in non-neonatal intensive care unit ward, and it is one of the risk factors in neonates with subsequent necrotizing enterocolitis(NEC) and usually lead to longed duration of hospitalization.
- Trial name
- NCT05055817
- Testing
- bloody stool group, non-bloody stool group
- Where
- China
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Atrial Fibrillation
Management of Gastrointestinal and Urogenital (GI/GU) Bleedings in Atrial Fibrillation Patients Using Pradaxa
This study is being conducted to collect data on the management of gastrointestinal and urogenital bleeding events occurring in patients with atrial fibrillation taking dabigatran etexilate.
- Trial name
- NCT02022020
- Where
- 22 sites in United States, Canada
- Volunteers
- 220 people
- Sponsor
- Boehringer Ingelheim
Upper Gastrointestinal Bleeding
Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial
This is a pragmatic, single center, feasibility pilot cluster randomized trial with embedded individual randomization to evaluate implementation strategies to increase the use of evidence-based practices to reduce upper…
- Trial name
- AEGIS (NCT05085405)
- Testing
- Clinician notification, Clinician Notification with Nurse Facilitation, Clinician Notification / Patient Activation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Obscure Gastrointestinal Bleeding
Cap Assisted Balloon Enteroscopy Versus Conventional Balloon Enteroscopy In The Evaluation Of Obscure Gastrointestinal Bleeding: A Randomized Controlled Trial
Gastrointestinal bleeding originating from the small bowel is difficult to diagnose and treat because the small bowel is difficult to see and reach.
- Trial name
- NCT02315404
- Testing
- CAP
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Washington University School of Medicine
Gastrointestinal Hemorrhage
The Clinical Feature of Ulcer Base Over Time After Prophylactic Argon Plasma Coagulation in Colonic EMR
The prophylactic APC right after colonic EMR doesn't mean the complete coagulation of visible vessel because of injection material.
- Trial name
- NCT02025764
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Healthy Volunteers
Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants
This study is researching experimental drugs called REGN9933 and REGN7508 (called "study drugs") and comparing their effects to approved treatments of rivaroxaban and aspirin (called "standard treatments").
- Trial name
- NCT06444178
- Testing
- Aspirin, REGN9933, REGN7508
- Where
- United Kingdom
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Fissure in Ano, Rectal Diseases
Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal Fissure
Anal fissure is a common anorectal diseases characterized by tear of the anoderm from the dentate line to the anal verge leading to pain and bleeding during and post defecation.
- Conditions
- Fissure in Ano, Rectal Diseases, Rectal Bleed
- Trial name
- NCT04887818
- Testing
- 2% Diltiazem ointment with 1.5% lidocaine, 0.3% Nifedipine ointment with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- University of Calgary
Variceal Bleeding, Portal Hypertension
Construction of a Portal Hypertension Biobank
Esophageal and gastric variceal bleeding (EGVB) is a severe complication of portal hypertension (PH), characterized by high bleeding volume, high rebleeding rate, and high mortality.
- Trial name
- NCT07419724
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Carcinoma (CRC), Right Hemicolectomy
The Intraoperative Technical Errors of Robotic vs. Laparoscopic Radical Right Hemiclectomy
Experimental design: This study is a multicenter, prospective, randomized, controlled phase III clinical trial that identifies, classifies, defines, and quantitatively analyzes technical errors between robotic and laparoscopic…
- Trial name
- NCT07138859
- Testing
- Robot assisted radical right hemicolectomy (D3 lymph node dissection), Laparoscopic assisted radical right hemicolectomy (D3 lymph node dissection)
- Where
- China
- Volunteers
- 368 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Pancreaticoduodenectomy, Pancreatectomy
Intraoperative Cell Saver Autotransfusion Use for Major Surgical Oncology Operations.
The purpose of this study is to demonstrate the safety and benefit of auto-transfusion filtered blood in patients undergoing major surgical oncology procedures.
- Conditions
- Pancreaticoduodenectomy, Pancreatectomy, Esophagectomy, Gastrectomy
- Trial name
- Cellsaver (NCT00708513)
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of Louisville
Upper GI Bleeding
Detection of Blood in the GI Lumen With HemoPill Acute
The goal of this clinical trial is to learn if the HemoPill acute (trial device) can detect the presence of blood in participants suspected of having upper gastrointestinal bleeding.
- Trial name
- DIRECT (NCT07868068)
- Testing
- HemoPill acute
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stony Brook University
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
GastroIntestinal Bleeding, Anemia
Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation.
- Trial name
- FIERCE (NCT05060731)
- Testing
- Oral iron supplementation, Intravenous iron supplementation
- Where
- Hungary
- Volunteers
- 570 people
- Sponsor
- University of Pecs
Liver Cirrhosis, Gastroesophageal Varices
Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography
Through the parameters of liver stiffness and spleen stiffness obtained by combi-elastography technique, summarize and analyze the warning index of esophagogastric variceal bleeding in patients with cirrhosis, so as to provide a…
- Conditions
- Liver Cirrhosis, Gastroesophageal Varices, Variceal Hemorrhage
- Trial name
- NCT04640350
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Coagulation Disorder, Cirrhosis, Liver
Heparin Like Effect in Acute Variceal Bleeding
This study attempts to clarify the pathophysiology of haemostasis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these patients.
- Conditions
- Coagulation Disorder, Cirrhosis, Liver, Variceal Hemorrhage
- Trial name
- NCT04111120
- Testing
- SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pancreatitis, Acute, Bleeding
Quick Large Balloon Dilatation for Removal of Large Bile Duct Stones (SHODBADI)
ESGE guidelines suggests 30-60 seconds endoscopic large balloon papillary dilation from the disappearance of the waist of the papilla.
- Conditions
- Pancreatitis, Acute, Bleeding, Cholangitis
- Trial name
- SHODBADI (NCT05061680)
- Testing
- endoscopic short duration papillary large balloon dilation
- Where
- 2 sites in Finland
- Volunteers
- 600 people
- Sponsor
- Helsinki University Central Hospital
Pancreatitis
Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery
Pancreatitis is caused by an acute injury on the pancreas. This illness is associated with abdominal pain, vomiting or even fever.
- Trial name
- NCT00357851
- Testing
- Aprotinin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nemours Children's Clinic