Clinical trials: Gastrointestinal Disorders, open to volunteers
IBS - Irritable Bowel Syndrome, Gastrointestinal Motility Disorder
Effects of Epetôme on Gastrointestinal Function, Inflammation and Wellbeing in Adults With IBS-like Symptoms (EPEGUT)
Irritable bowel syndrome (IBS) is a common functional gastrointestinal condition characterised by symptoms including abdominal pain or discomfort, bloating, altered bowel habits and changes in digestive comfort.
- Trial name
- EPEGUT (NCT07916948)
- Testing
- EPEGUT
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
Post-traumatic Stress Symptoms, Anxiety
Psychological Prehabilitation for Complex Gastrointestinal Surgery
The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI.
- Conditions
- Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
- Trial name
- PREPARE-GI (NCT07865052)
- Testing
- PREPARE-GI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Functional Gastrointestinal Disorders
Exploring Novel Therapeutic Approaches for Disorders of Gut-Liver-Brain Interaction-H1/H2
Functional dyspepsia (FD) is associated with inflammatory responses caused by the release of histamine from eosinophils and mast cells, leading to increased intestinal mucosal permeability, which is a key pathogenic mechanism.
- Trial name
- NCT07857941
- Testing
- Famotidine, Levocetirizine, Fuyuan Gasmin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS)
Mechanism of FODMAP Restriction on FGID Patients
Brief Summary : The goal of this clinical trial is to investigate the effects of differing FODMAP diets on gut microbiota, gut barrier function, symptom severity, quality of life, and psychological status in FGID patients.
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS), Functional Dyspepsia
- Trial name
- BRIDGE (NCT07000227)
- Testing
- Low FODMAP diet, Gentle FODMAP diet, Traditional Dietary Advice
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies.
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders (FGIDs), Gastrointestinal and Digestive Disorder
- Trial name
- NCT07222943
- Testing
- Guided Imagery Therapy
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Baylor College of Medicine
Multiple Myeloma, GI Cancer
Gustabor Phase 1 - AI-based Creation of a Nutritional Plan to Compensate for Chemotherapy-induced Taste Disorders
The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation.
- Conditions
- Multiple Myeloma, GI Cancer, Taste Disorders
- Trial name
- GustaborPilot (NCT07040189)
- Testing
- Gustabor server
- Where
- 3 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Wuerzburg University Hospital
Functional Gastrointestinal Disorders (FGIDs), Infant Discomfort
Effects of Goat Milk Formula on Gastrointestinal Comfort and Growth in Infants
Infant gastrointestinal discomfort is common in early life and can affect feeding, sleep, and overall well-being. Goat milk formula, due to its unique protein composition and smaller fat globules, may be easier to digest and…
- Trial name
- NCT07778927
- Testing
- Goat Milk Formula, Cow Milk Formula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Eosinophilic Gastrointestinal Disorders (EGID)
Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal Disorders
This prospective observational cohort study aims to evaluate clinical and histologic outcomes of elimination diets in children aged 2-17 years with eosinophilic gastrointestinal disorders (EGIDs).
- Trial name
- NCT07779772
- Testing
- Elimination Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Cukurova University
Multiple Myeloma (MM), GI Cancer
Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention
The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation.
- Conditions
- Multiple Myeloma (MM), GI Cancer, Taste Disorder, Melanoma (Skin Cancer)
- Trial name
- GustaborRCT (NCT07649681)
- Testing
- Gustabor server, Standard Recommendations
- Where
- 6 sites in Germany
- Volunteers
- 198 people
- Sponsor
- Wuerzburg University Hospital
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Functional Gastrointestinal Disorders
Functional GI Disease Registry
The goal of this study is to establish a prospective observational cohort of individuals with functional GI disorders (functional constipation, irritable bowel syndrome, chronic nausea, functional diarrhea, and functional…
- Trial name
- FGIDR (NCT05295446)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Functional Gastrointestinal Disorders (FGIDs), Weight Loss
Effects of Multi-strain Bacillus Spore Probiotics on Growth, Digestive Function, and Gut Microbiota in Cesarean-Delivered Neonates
Infants born by cesarean section commonly show early weight loss and slower recovery of birth weight, together with characteristic patterns of gut microbiota dysbiosis marked by reduced Bifidobacterium and Bacteroides and…
- Trial name
- NCT07320287
- Testing
- RO water, LiveSpo PREG-MOM, LiveSpo CONSY
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Inflammatory Bowel Disease, Ulcerative Colitis Type, Functional Disorder of Gastrointestinal Tract
Evaluation of the Effects of Colipral on Microbiota Gut Composition in Patients Presenting With Ulcerative Colitis During Remission Phase and Functional Disorders
The study is a double-blind, placebo-controlled, crossover, randomised trial, in which enrolled subjects will be included for 18 months.
- Trial name
- COLIPRAL (NCT07751081)
- Testing
- Food Supplement Colipral in film-coated tablets containing Escherichia coli 5C LMG S-33222
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Upper Gastrointestinal Disorders
Effect of Virtual Reality Before Upper Gastrointestinal Endoscopy on Preprocedural Anxiety, Psychological Readiness, and Postprocedural Satisfaction
Objective: This study aims to evaluate the effect of virtual reality applied before upper gastrointestinal endoscopy on preprocedural anxiety, psychological readiness, and postprocedural satisfaction.
- Trial name
- NCT07745959
- Testing
- Virtual Reality, Standard Preprocedural Care
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ardahan University
Upper Gastrointestinal Disorder
Endoscopists' Perspectives on the Use of Single-Use Gastroscopes in Elective and Subacute Patients in the Endoscopy Unit
The aim of this clinical trial is to investigate whether single-use gastroscopes perform comparably to reusable gastroscopes when used in an endoscopy unit during a period of reduced endoscope reprocessing capacity.
- Trial name
- NCT07727226
- Testing
- Ambu aScope Gastro, Reusable diagnostic gastroscopes (Olympus)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Zealand University Hospital
ADHD, Gastrointestinal
ADHD, Gut Problems and Synbiotic
The scope of this study is to evaluate the impact of a synbiotic product (a combination of probiotic bacteria and prebiotics) on symptoms reported by participants with ADHD.
- Conditions
- ADHD, Gastrointestinal, Emotion Regulation Abilities
- Trial name
- NCT07717359
- Testing
- Synbiotic Cap Gut-Brain
- Volunteers
- 174 people
- Sponsor
- Super Synbiotics AB
Upper Gastrointestinal Disorder
Performance Characteristics and Technical Outcomes of Single-use Gastroscopes Used Bedside Versus Reusable Gastroscopes Used in the Endoscopy Unit Evaluated in Subacute Patients
The aim of this study is to investigate whether single-use gastroscopes used bedside can reduce the time from indication to procedure compared with re-usable gastroscopes used at the endoscopy unit in patients referred to a…
- Trial name
- NCT06771102
- Testing
- Ambu aScope Gastro, Diagnostic gastroscopes, Olympus
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Zealand University Hospital
Lower Gastrointestinal Disorder, Tolerance
A Pilot Study of Commercially Available Bowel Preparation Regimens Packaged and Ingested Via Vegan Capsules
The goal of this clinical trial is to learn whether bowel preparation powders used before colonoscopy can be taken as capsules instead of being mixed and drunk as a liquid.
- Trial name
- CLEAR-CAP (NCT07700277)
- Testing
- Sodium picosulfate, magnesium oxide, and citric acid capsules, Polyethylene glycol 3350 with electrolytes capsules
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute