Clinical trials: Gastrointestinal Dysbiosis
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Short Bowel Syndrome, Complications
Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications
There are no reports involved the intestinal microbiota from Chinese infants with short bowel syndrome (SBS) under different clinical status.
- Trial name
- MSBS (NCT02699320)
- Testing
- Complications
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Irritable Bowel Syndrome, Obesity
Moderate Continuous Versus High Interval Intensity Training on Gut Dysbiosis and GLP1 Hormone in IBS
investigating the response of gut bacteria via measuring short chain fatty acids and Glucagon like peptide hormone to two different modes of exercises in pre-diabetic, obese patients with irritable bowel syndrome.
- Conditions
- Irritable Bowel Syndrome, Obesity, Dysbiosis
- Trial name
- NCT06408610
- Testing
- moderate intensity continuous training
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Hepatic Encephalopathy, Dysbiosis
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
This interventional study aims to evaluate the safety and efficacy of oral capsule fecal microbiota transplantation (FMT) for treating hepatic encephalopathy refractory to conventional rifaximin and lactulose therapy in patients…
- Trial name
- NCT06368895
- Testing
- Fecal microbiota transplantation delivery through colonoscopy, Fecal microbiota transplantation delivery through oral capsules
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dysbiosis, Sarcopenia
Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet
The long-term study objective is to develop optimized nutritional therapies for surgery and test them in clinical practice. This pilot study will test a microbiome-optimization diet in colorectal cancer surgery patients.
- Conditions
- Dysbiosis, Sarcopenia, Colon Cancer
- Trial name
- NCT05658263
- Testing
- Standard Diet, BIG MACS Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Inflammatory Bowel Disease (IBD), Dysbiosis
Oral Microbiota Dysbiosis in IBD
This study aims to provide new insights into oral microbiota dysbiosis and IBD. Given the strong association between oral health, microbiome composition, and IBD, all participants will undergo an oral evaluation program conducted…
- Trial name
- MIBD (NCT06980818)
- Testing
- No intervention
- Where
- Portugal
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- ULS Viseu Dão Lafões
Cystic Fibrosis, Abdominal Pain
Rifaximin for Treatment of Bloating in Children and Adults With Cystic Fibrosis
Gastrointestinal symptoms are commonly reported in as much as 65% of people with CF even independent of pancreatic enzyme replacement therapy (PERT) and the most frequent of these symptoms are bloating/distension, flatulence…
- Conditions
- Cystic Fibrosis, Abdominal Pain, Small Bowel Disease
- Trial name
- NCT05408910
- Testing
- Rifaximin 550 MG Oral Tablet [XIFAXAN]
- Sponsor
- Wake Forest University Health Sciences
Ulcerative Colitis
Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis
Ulcerative Colitis (UC) is a chronic Inflammatory Bowel Disease characterized by chronic inflammation of the colon. Composition of gut microbiota of UC patients is abnormal (dysbiosis).
- Trial name
- ABRICO (NCT06228352)
- Testing
- Feces collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontal Diseases, Gastritis
Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions
The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.
- Trial name
- NCT07378540
- Testing
- saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Intestinal Disease
Outcomes of Outpatients in an Gut Microbiota Clinic
The gut microbiota plays a crucial role in human health, influencing metabolism, immunity, and pathogen resistance. Research has linked microbiome dysbiosis to various intestinal and extra-intestinal disorders, prompting interest…
- Trial name
- Microfec (NCT06845527)
- Testing
- Microbiome testing and Cytokine profiling
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis
The goal of this study is to assess if oral vancomycin can restore the normal bile acid metabolism of people with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease.
- Trial name
- NCT02464020
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Diarrhea Caused by Drug, Dysbiosis
Monitoring the Effects of Probiotic Supplementation in Immunocompromised Kidney Transplanted Subjects
In order to protect their new renal graft, post-transplant patients follow a rigorous immunosuppressive therapy combined with prophylactic antibiotic treatment.
- Trial name
- NCT05102461
- Testing
- Florajen Digestion Supplementation
- Where
- United States
- Sponsor
- State University of New York - Upstate Medical University
Irritable Bowel Syndrome
Irritable Bowel Syndrome Evaluation and Treatment in Primary Care
Overview of Methods: This is a double blind, randomized controlled trial with a non-balanced randomization and a cross-over to active treatment for placebo treated individuals who do not respond to the placebo treatment.
- Trial name
- NCT01641341
- Testing
- Bifidobacterium infantis, Pancrelipase, Nitazoxanide
- Where
- 9 sites in United States
- Volunteers
- 61 people
- Sponsor
- American Academy of Family Physicians
Inflammatory Bowel Disease
Does the Microbiome in IBD Change Alongside Special Treatment Scenarios?
The purpose of this cohort study is to map, during one year in an e-health setting, patients having Inflammatory Bowel Disease (IBD) with mild to moderate activity in relation to dysbiosis (gut bacteria) and inflammation burden…
- Trial name
- NCT02526251
- Testing
- observational
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Nordsjaellands Hospital
Infant, Newborn, Gut -Microbiota
Infant Microbiota Restoration With Maternal Microbes
The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants.
- Conditions
- Infant, Newborn, Gut -Microbiota, Gut Dysbiosis, Cesarean Delivery Affecting Newborn
- Trial name
- MaMi (NCT07212361)
- Testing
- Probiotic
- Where
- 2 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Hepatocellular Carcinoma
Microbiota Modification for Immuno-oncology in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common liver primary cancer with a high rate of mortality. Since the results of IMbrave150, immunotherapy have emerged as a standard of care for HCC patients advanced and/or unresectable…
- Trial name
- MOTHER (NCT06551272)
- Testing
- EXL01
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- Center Eugene Marquis
Sepsis, Critical Illness
FMT for 90-Day Outcome of Clinical Use in ICU Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, representing one of the leading causes of death in intensive care units (ICUs) worldwide.
- Conditions
- Sepsis, Critical Illness, Gastrointestinal Dysfunction, Dysbiosis
- Trial name
- FOCUS (NCT07670299)
- Testing
- Gut microbiota suspension
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness, Dysbiosis
Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
This study evaluates the effects of either Pediasure or Nourish formulas on the gastrointestinal microbiome in critically-ill children. Patients will be randomized to received either Pediasure or Nourish.
- Conditions
- Critical Illness, Dysbiosis, Pediatric ALL
- Trial name
- NCT03414775
- Testing
- Nourish, Pediasure
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh