Clinical trials: Gastrointestinal Dysbiosis
Functional Gastrointestinal Disorders (FGIDs), Weight Loss
Effects of Multi-strain Bacillus Spore Probiotics on Growth, Digestive Function, and Gut Microbiota in Cesarean-Delivered Neonates
Infants born by cesarean section commonly show early weight loss and slower recovery of birth weight, together with characteristic patterns of gut microbiota dysbiosis marked by reduced Bifidobacterium and Bacteroides and…
- Trial name
- NCT07320287
- Testing
- RO water, LiveSpo PREG-MOM, LiveSpo CONSY
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Endometriosis, Microbiome Dysbiosis
Trial Evaluating Nutritional Fiber in Digestive Symptoms of Endometriosis
This study is a double-blind, randomized, placebo-controlled study that evaluates the safety and tolerability of a fiber-based dietary supplement and the mechanistic and structure-function effects of that supplement on the gut…
- Conditions
- Endometriosis, Microbiome Dysbiosis, Gastrointestinal Symptoms
- Trial name
- TEND (NCT07875062)
- Testing
- Fiber
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Periodontal Diseases, Gastritis
Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions
The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.
- Trial name
- NCT07378540
- Testing
- saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Dysbiosis, Clostridium Difficile
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs
Antimicrobial therapy can lead to disruption of the gut microbiome and infection with Clostridioides difficile, a disease associated with high morbidity and mortality, particularly among the elderly.
- Conditions
- Dysbiosis, Clostridium Difficile, Pet-Human Bonding, Antibiotic-Associated Colitis
- Trial name
- NCT05622721
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Congenital Heart Disease, Intestinal Disease
Effect of Probiotics on Patients With Congenital Heart Disease Following Cardiopulmonary Bypass
A randomized, controlled study including infants with non-cyanosis congenital heart disease (CHD) in need of surgical correction involving cardiopulmonary bypass (CPB) was established.
- Conditions
- Congenital Heart Disease, Intestinal Disease, Dysbiosis
- Trial name
- NCT06295575
- Testing
- probiotics containing Bifidobacterium infantis and Lactobacillus
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Children's Hospital
Inflammatory Bowel Disease (IBD)
Setting up a Cohort of Patients With Inflammatory Bowel Disease and a Cohort of Patients Without Chronic Inflammatory Bowel Disease
The objective of this study is to constitute cohorts of IBD versus non-IBD patients to identify (a) new biomarker(s) of intestinal dysbiosis associated with inflammatory bowel disease, and develop a prototype for assaying such…
- Trial name
- ELITE (NCT06502873)
- Testing
- biological samples collection
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Artialis
Irritable Bowel Syndrome
Irritable Bowel Syndrome Evaluation and Treatment in Primary Care
Overview of Methods: This is a double blind, randomized controlled trial with a non-balanced randomization and a cross-over to active treatment for placebo treated individuals who do not respond to the placebo treatment.
- Trial name
- NCT01641341
- Testing
- Bifidobacterium infantis, Pancrelipase, Nitazoxanide
- Where
- 9 sites in United States
- Volunteers
- 61 people
- Sponsor
- American Academy of Family Physicians
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
The goal of this clinical trial is to learn if an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS).
- Trial name
- NCT07768267
- Testing
- Biocidin REMOVE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Sepsis, Critical Illness
FMT for 90-Day Outcome of Clinical Use in ICU Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, representing one of the leading causes of death in intensive care units (ICUs) worldwide.
- Conditions
- Sepsis, Critical Illness, Gastrointestinal Dysfunction, Dysbiosis
- Trial name
- FOCUS (NCT07670299)
- Testing
- Gut microbiota suspension
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis
The goal of this clinical trial is to learn how oral vancomycin therapy may contribute in treating paediatric inflammatory bowel disease, particularly atypical ulcerative colitis and PSC-associated colitis.
- Conditions
- Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC), Pediatric Inflammatory Bowel Diseases
- Trial name
- VERDA (NCT07646223)
- Testing
- Oral Vancomycin
- Where
- Finland
- Volunteers
- 140 people
- Sponsor
- Tampere University Hospital
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Crohn's Disease
COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk)
The cause of CD could be different according to age at onset of CD symptoms. Indeed we know that some very young patients at CD diagnosis have particular genetic variants as abnormalities of the IL10R that are regarded as quite…
- Trial name
- COMeBACk (NCT02839317)
- Testing
- Biological
- Where
- 5 sites in France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Irritable Bowel Syndrome
Tritordeum-based Foods for IBS Symptoms
People with irritable bowel syndrome (IBS), especially those with diarrhea (IBS-D), often describe worsening symptoms after eating certain foods.
- Trial name
- TritoinIBS (NCT05307185)
- Testing
- Tritordeum-based food
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Irritable Bowel Syndrome, Dysbiosis
Fecal Microbiota Transplantation and ACHIM for Manipulating Gut Microbiota in IBS Patients
The double-blinded placebo-controlled study compares the effect of fecal microbiota transplantation vs. Anaerobically Cultivated Human Intestinal Microbiota (ACHIM) or placebo (own feces) on manipulating the gut microbiota in…
- Trial name
- NCT05088434
- Testing
- Anaerobically Cultivated Human Intestinal Microbiota (ACHIM), Donor fecal microbiota transplantation
- Where
- Norway
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Inflammatory Bowel Disease
Does the Microbiome in IBD Change Alongside Special Treatment Scenarios?
The purpose of this cohort study is to map, during one year in an e-health setting, patients having Inflammatory Bowel Disease (IBD) with mild to moderate activity in relation to dysbiosis (gut bacteria) and inflammation burden…
- Trial name
- NCT02526251
- Testing
- observational
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Nordsjaellands Hospital
IBS - Irritable Bowel Syndrome, Post Infection Syndrome
Gut Microbiome in Patients With Post-infectious Irritable Bowel Syndrome
Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS).
- Trial name
- MicroRestore (NCT07517029)
- Where
- Italy
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Cirrhosis
Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis
This study looks at memory problems after surgery in people with liver disease. We want to know how often these problems happen and what might cause them. The main question it aims to answer is: 1.
- Trial name
- NCT07012434
- Volunteers
- 133 people
- Sponsor
- Sichuan Provincial People's Hospital
Nutritional and Metabolic Diseases
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
This study is designed as a retrospective cohort study to evaluate the potential of diagnostic procedures in defining populations of patients self-reporting unexpected and uncontrollable episodes of body odor and/or halitosis.
- Trial name
- NCT02692495
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Mebo Research, Inc.