Clinical trials: Gastrointestinal Dysplasia
Early Gastric Cancer, Gastric Adenoma
Magnifying Endoscopy With Narrow Band Imaging Versus Endoscopic Ultrasonography for Prediction of Tumor Invasion Depth in Early Gastric Cancer: A Prospective Comparative Study
The treatment of early gastric cancer can be divided into endoscopic resection and surgery, and the precise staging of early gastric cancer is very important to prevent unnecessary surgery or additional surgery after the…
- Conditions
- Early Gastric Cancer, Gastric Adenoma, Gastric Dysplasia
- Trial name
- NCT03546257
- Testing
- magnifying endoscopy with narrow band imaging (ME-NBI)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yonsei University
IPMN, Pancreatic, Pancreas Cancer
The LINFU® U.S. Registry in Patients With IPMN (Intraductal Papillary Mucinous Neoplasm of the Pancreas)
In this study, LINFU® will be evaluated in patients who have been identified with IPMN to determine if it can be used to help identify early, pancreatic ductal adenocarcinoma and its noninvasive precursor lesions (dysplasia).
- Conditions
- IPMN, Pancreatic, Pancreas Cancer, Pancreatic Cyst
- Trial name
- NCT06276764
- Testing
- LINFU®
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC
Barrett Esophagus, Barrett's Esophagus Without Dysplasia
Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting
The investigators will conduct a large study in the primary care clinic to determine the feasibility of using tethered capsule endomicroscopy as a screening method for Barrett's esophagus (BE) in the primary care practice…
- Conditions
- Barrett Esophagus, Barrett's Esophagus Without Dysplasia, Barretts Esophagus With Dysplasia
- Trial name
- NCT04561791
- Testing
- Tethered Capsule Endomicroscopy
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colonic Polyp
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps).
- Trial name
- NCT01062035
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal
Zinc Supplementation on Very Low Birth Weight Infant
Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections. Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the…
- Conditions
- Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
- Trial name
- NCT04050488
- Testing
- Zinc Sulfate
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Pancreas Adenocarcinoma, Dysplasia
A Proof-of-Concept Study Evaluating LINFU™
The purpose of this research study is to study a method to detect pancreatic precancer and cancer (ductal adenocarcinoma) using ultrasound technology in those who are at significantly increased risk for developing pancreatic…
- Trial name
- NCT05161013
- Testing
- LINFU™
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC
Barrett's Esophagus
Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer
In this prospective single center study, up to 25 patients with Barrett's esophagus with LGD or no dysplasia (Group 1), 25 patients with HGD/IMCA (Group 2), 25 patients with esophageal carcinoma confined to the esophageal wall…
- Trial name
- NCT00628784
- Testing
- Endoscopic spray cryotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Gastric Lesion, Gastritis
Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios
The goal of this clinical trial is to evaluate the diagnostic accuracy of the AI-integrated Capsule Gastroscopy (ACG) system in simulated home-use conditions for detecting upper gastrointestinal (UGI) abnormalities.
- Conditions
- Gastric Lesion, Gastritis, Upper Gastrointestinal Bleeding (UGIB), Gastric Dysplasia
- Trial name
- NCT06848400
- Testing
- AI-integrated Capsule Gastroscopy (ACG) examination, Electronic gastroduodenoscopy (EGD) examination
- Where
- 12 sites in China, Hong Kong and 1 more
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pancreatic Ductal Adenocarcinoma, Familial Pancreatic Cancer
A Study of IMMray™ PanCan-d Test for Early Detection of Pancreatic Cancer in High-risk Groups
PanFAM-1 is a clinical study for early detection of pancreatic cancer in high-risk groups. The goals of the study are to assess the performance and diagnostic accuracy of the IMMray™ PanCan-d test compared to standard-of-care…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Familial Pancreatic Cancer, FAMMM - Familial Atypical Mole Malignant Melanoma Syndrome
- Trial name
- NCT03693378
- Where
- 21 sites in United States, Canada and 3 more
- Volunteers
- 1,349 people, healthy volunteers welcome
- Sponsor
- Immunovia, Inc.
Functional Dyspepsia, Gastritis
The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies
The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions: 1.
- Conditions
- Functional Dyspepsia, Gastritis, Gastritis Chronic, Gastric Cancer (GC)
- Trial name
- HELIS (NCT07770126)
- Where
- 3 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Bronchopulmonary Dysplasia, Necrotizing Enterocolitis
Treatment of Classic Mid-trimester PPROM by Means of Continuous Amnioinfusion
Objective: Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal mem-branes prior to 28 weeks' gestation (WG), complicates approximately 0.4-0.7% of all pregnancies and associated with very…
- Conditions
- Bronchopulmonary Dysplasia, Necrotizing Enterocolitis, Intracranial Hemorrhages
- Trial name
- AmnionFlush (NCT04696003)
- Testing
- Continuous amnioinfusion with Amnion Flush Solution through the intraamniotic catheter
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Anal Dysplasia
Assessing the Utility of Plasma ctHPVDNA for Anal Cancer Screening
The study is to test a liquid biopsy assay for screening and classifying anal dysplasia from blood.
- Trial name
- SCAN-LITE (NCT06971276)
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Tuberculosis, Gastric Cancer
Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendly novel nano-chemo sensors that can…
- Conditions
- Tuberculosis, Gastric Cancer, Peptic Ulcer, Atrophic Gastritis
- Trial name
- Volatolome (NCT03228095)
- Testing
- VOC detection in breath and in skin headspace, Breath sampling, Upper endoscopy with biopsies
- Where
- Latvia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Colonic Polyp, Colonic Diseases
Optical Polyp Testing for In Vivo Classification
Small growths detected in the colon (polyps) during a colonoscopy may or may not have the potential to develop into cancer. However, since visual inspection alone cannot separate all potentially harmful polyps from harmless ones…
- Conditions
- Colonic Polyp, Colonic Diseases, Colonic Neoplasms, Colonic Adenoma
- Trial name
- OPTIC (NCT03139942)
- Testing
- Optical spectral reflectance and autofluorescence imaging
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mild Dysplasia of Esophagus, Moderate Dysplasia of Esophagus
Performance of White Light, NBI and Iodine Staining Endoscopy in the Diagnosis of Esophageal Lesions
The investigators aim to evaluate the performance of Narrow Band Imaging (NBI) endoscopy in Esophageal Squamous Cell Carcinoma (ESCC) screening, as compared to the currently used White Light Endoscopy (WLE) and Lugol's Iodine…
- Conditions
- Mild Dysplasia of Esophagus, Moderate Dysplasia of Esophagus, Severe Dysplasia of Esophagus, Carcinoma in Situ of Esophagus
- Trial name
- NCT04170257
- Testing
- Endoscopic examination using white light, NBI and iodine staining
- Where
- 5 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Colonic Neoplasms, Colonic Polyps
Strigolactones and Dysplastic Colonic Lesions or Cancer
The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
- Trial name
- NCT02824835
- Testing
- biopsy during colonoscopy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto