Clinical trials: Gastrointestinal Irritation
Gulf War Illness, Persian Gulf Syndrome
Exercise in Gulf War Illness (GWI)
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional…
- Trial name
- NCT01291758
- Testing
- Submaximal bicycle exercise stress tests performed 24 hr apart
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Migraine, Irritable Bowel Syndrome
Effects of a Multispecies Probiotic on Migraine
The prevalence of migraine is higher in female patients with various intestinal diseases. An explanation could be that migraine is caused by a leaky gut, defined by increased intestinal permeability that permits particles to pass…
- Conditions
- Migraine, Irritable Bowel Syndrome, Headache, Migraine
- Trial name
- NCT04696458
- Testing
- Lactobacillus plantarum (CECT7484 and CECT7485)/ Pediococcus acidilactici (CECT7483)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scripps Health
Irritable Bowel Syndrome
Heart Rate Variability in Patients With Irritable Bowel Syndrome Before and After Gut-directed Hypnotherapy
Dysregulation of the brain-gut-axis is believed to underlie symptom generation in irritable bowel syndrome (IBS). The Autonomous Nervous System (ANS) is an important route of brain-gut communication and aberrant ANS functioning…
- Trial name
- NCT05283655
- Testing
- Gut-directed hypnotherapy
- Volunteers
- 17 people
- Sponsor
- Medical University of Vienna
Ulcerative Colitis, Crohn Disease
Microbial and Human Determinants of the Onset of IBD Flares
This is a longitudinal, observational study that aims to identify the microbial and human molecular triggers of IBD flares via stool, saliva, and blood metatranscriptomes, whole blood proteome, and collected clinical metadata.
- Conditions
- Ulcerative Colitis, Crohn Disease, Irritable Bowel, Crohns Disease Aggravated
- Trial name
- NCT05463900
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Viome
Irritable Bowel Syndrome, Sexual Dysfunction
Visceral Sensitivity in Women With BS and Sexual Dysfunction
This study aims to compare visceral rectal sensitivity and quality of life of 40 Irritable Bowel Syndrome women, with (20) and without sexual dysfunction (20).
- Trial name
- IBS (NCT04716738)
- Testing
- Blood analyses and coprological
- Volunteers
- 20 people
- Sponsor
- Hospital General de Mexico
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Irritable Bowel Syndrome
Faecal Microbiota Transplantation (FMT) in Patients With IBSmechanism(s) of Action
Two hundrad patients are randomized to either 90 g transplant, 90 g transplant twice with 1week interval into the distal small intestine via working channel of a gastroscope, or to 90 g transplant into the coecum of the colon via…
- Trial name
- NCT04236843
- Testing
- Feces
- Where
- Norway
- Volunteers
- 186 people
- Sponsor
- Helse Fonna
Irritable Bowel Syndrome (IBS)
The Role That Food and Bacteria Play in Generating Abdominal Pain
Irritable Bowel Syndrom (IBS) affects up to five percent of Canadians and has proven difficult to treat. Our research will explore how a type of dietary carbohydrate, called FODMAPS, contributes to chronic abdominal pain in…
- Trial name
- NCT07688044
- Testing
- FODMAP Challenge
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- David Reed
Irritable Bowel Syndrome, Inflammatory Bowel Disease
25-hydroxyvitamin D and Fatigue: The VITALITY Study
The burden of chronic disease is continuing to rise. Even though patients may be in remission or have quiescent disease, several studies have confirmed that symptoms, such as e.g., fatigue, is troublesome.
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Disease, Diabetes, Rheumatoid Arthritis
- Trial name
- NCT01718925
- Volunteers
- 614 people
- Sponsor
- Ostfold Hospital Trust
Irritable Bowel Syndrome
Probiotics in Intestinal Bacterial Overgrowth
The aim of the present study is to demonstrate the effect of a mixture of four species of probiotics (Saccharomyces boulardii, Bifidobacterium lactis BB-12, Lactobacillus acidophilus LA-5 and Lactobacillus plantarum) in patients…
- Trial name
- NCT02204891
- Testing
- Probiotics in SIBO, Probiotics
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Irritable Bowel Syndrome
Efficacy Evaluation of a Commercial Preparation Containing Lactobacillus Casei DG on the Reduction of the Painful Symptoms Related to the Irritable Bowel Syndrome (IBS). A Pilot Clinical Study
The purpose of this study is to evaluate the efficacy of a treatment with Lactobacillus casei DG in the reduction of the painful symptoms in patients affected by irritable bowel syndrome.
- Trial name
- NCT02077699
- Testing
- Lactobacillus casei DG
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- SOFAR S.p.A.
Irritable Bowel Syndrome, Abdominal Pain
Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS
The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS).
- Trial name
- NCT04315714
- Testing
- Yoga Program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Irritable Bowel Syndrome
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
Participants with IBS (all subtypes) and with no exclusionary comorbid psychiatric or medical disorders will be enrolled in the study.
- Trial name
- NCT06206265
- Testing
- TRYP-0082, Psychotherapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- TRYP Therapeutics
Irritable Bowel
Effect of 6 Weeks Daily Consumption of a Cereal-based Juice Beverage on Gastrointestinal Health
The project is a randomized, 2-way, blinded parallel trial in which 56 healthy adults of both genders with frequent occurrence of stomach trouble.This intervention trial with 6 weeks of daily intake β-glucans will be carried out…
- Trial name
- NEWDRINK (NCT03046667)
- Testing
- Barley β-glucan, Control
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Irritable Bowel Syndrome
Efficacy and Safety of Saccharomyces Boulardii in the Treatment of Small Intestinal Bacterial Overgrowth
Non-constipated irritable bowel syndrome is a common disorder that may be related to small intestinal bacterial overgrowth. Saccharomyces boulardii CNCM I-745 is a probiotic yeast that has proven efficacy for the treatment of…
- Trial name
- NCT04627337
- Testing
- Saccharomyces Boulardii 250 MG, Dietary advice following a low fermentation diet
- Where
- Argentina
- Volunteers
- 71 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Irritable Bowel Syndrome
Open International Study on Quality of Life in Irritable Bowel Syndrome (IBS) Patients Before and After 8 Weeks Treatment With Mebeverine/Pinaverium Bromide
A study to evaluate, by country and overall, the changes from baseline of the irritable bowel syndrome quality of life (IBS QoL) total score after 4 and 8 weeks of treatment with Duspatalin® or Dicetel® in IBS patients.
- Trial name
- NCT01678781
- Where
- 24 sites in China, Egypt and 2 more
- Volunteers
- 607 people
- Sponsor
- Abbott
Irritable Bowel Syndrome
Treatment of IBS in Primary Health Care.
The purpose of this study is to retrospectively evaluate treatment strategies for IBS used within primary Health care in Örebro Region.
- Trial name
- NCT05144581
- Volunteers
- 3,000 people
- Sponsor
- Region Örebro County
Irritable Bowel Syndrome With Diarrhea (IBS-D)
Efficacy, Safety and Tolerability of DNK333 (25 mg Bid) in Women With Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
The purpose of this study is to evaluate the efficacy of DNK333 compared to placebo for relieving symptoms of IBS-D in female patients.
- Trial name
- NCT00394173
- Testing
- DNK333
- Where
- 43 sites in United States, Canada
- Volunteers
- 180 people
- Sponsor
- Novartis
Irritable Bowel Syndrome
Efficacy of an Encapsulated Probiotic Bifidobacterium Infantis 35624 in Irritable Bowel Syndrome
The purpose of this study was to determine the dose-ranging efficacy and safety profile of encapsulated Bifidobacterium infantis 35624 in female subjects with irritable bowel syndrome (IBS).
- Trial name
- NCT00135031
- Testing
- Bifidobacterium infantis 35624
- Where
- 20 sites in United Kingdom
- Volunteers
- 362 people
- Sponsor
- Procter and Gamble