Clinical trials: Gastrointestinal Lesions
Intraoperative Bleeding, Liver Diseases
GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery
This is a pre-market, prospective, randomized (1:1), multicenter, pivotal clinical investigation. The purpose of this investigation is to determine the clinical performance of GATT-Patch as compared with SURGICEL® Original for…
- Conditions
- Intraoperative Bleeding, Liver Diseases, Gallbladder Diseases, Hemorrhage, Surgical
- Trial name
- NCT05900037
- Testing
- GATT-Patch, SURGICEL® Original
- Where
- 6 sites in United States
- Volunteers
- 53 people
- Sponsor
- GATT Technologies BV
Iron Deficiency Anemia
Location of Lesions Responsible for Blood Loss in the Gastrointestinal (GI) Tract
The purpose of this study is to identify the prevalence, nature and location of lesions in the GI tract that may contribute to iron deficiency anaemia and compare diagnostic yied of the upper GI magnetic controlled capsule…
- Trial name
- A-MACE (NCT04840433)
- Testing
- MACE
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Cancer of Pancreas, Pancreas Cyst
Tumour Regulatory Molecules in Early Pancreatic Cancer Detection
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis.
- Trial name
- TEM-PAC (NCT03536793)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Hepatic Neoplasms
Identification of Hepatic Lesions
Patients with suspicion of primary or secondary hepatic malignancy in whom a radiological examination is needed in order to decide on the most appropriate treatment.
- Trial name
- NCT00307866
- Testing
- Resovist (BAY86-4884, SH U 555 A)
- Where
- 19 sites in Italy
- Volunteers
- 218 people
- Sponsor
- Bayer
Colorectal Neoplasms, Colonic Polyps
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
This prospective randomized controlled study aims to evaluate the diagnostic accuracy of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for detection and optical characterization of…
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Adenoma, Serrated Polyps
- Trial name
- INSIGHT (NCT07797361)
- Testing
- White Light Endoscopy, Versatile Intelligent Staining Technology, Spectral Flexible Imaging
- Where
- Brazil
- Volunteers
- 990 people
- Sponsor
- Alexandre Vontobel Padoin
Hepatocellular Cancer, Liver Cirrhoses
Comparing the Diagnostic Efficiencies of CEUS and EOB-MRI in Patients With High Risk of HCC
HCC is a serious threat to the health of people. Accurate diagnosis of early HCC by imaging allows patients to obtain proper treatment.
- Conditions
- Hepatocellular Cancer, Liver Cirrhoses, Diagnoses Disease
- Trial name
- NCT04212286
- Testing
- Diagnostic CEUS and EOB-MRI
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Tianjin Third Central Hospital
Pancreatic Cancer, Chronic Pancreatitis
Diagnostic Utility of Protein Biomarkers in Pancreatic Ductal Adenocarcinoma
The goal of this prospective multicenter observational study is to evaluate the diagnostic accuracy of blood-based protein biomarkers for detecting pancreatic ductal adenocarcinoma (PDAC) in adults aged 18 years and older.
- Conditions
- Pancreatic Cancer, Chronic Pancreatitis, Intraductal Papillary Mucinous Neoplasm, Mucinous Cystic Neoplasm
- Trial name
- NCT07875582
- Testing
- Blood-Based Protein Biomarker Assessment
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Celiac Disease, Small Bowel Mucosal Atrophy or Lesions
AI System for Detection and Characterization of Chronic Enteropathies
Coeliac disease (CD) is an immune-mediated enteropathy leading to small intestinal mucosal atrophy. Diagnosis relies on serology and duodenal biopsies, but it can be complicated by patchy lesions and differential diagnosis with…
- Conditions
- Celiac Disease, Small Bowel Mucosal Atrophy or Lesions, Non-celiac Enteropathies
- Trial name
- NCT07387185
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Disease of Pancreatic or Periampullary Lesions
PoLyglycolic Acid Felt reiNforcEmenT of the PancreaticoJejunostomy (PLANET-PJ Trial)
The polyglycolic acid (PGA) felt is a felt-like absorbable suture reinforcing material. The pancreatojejunostomy aimed at reducing POPF is not established at present. We devised a new method using doubly PGA felt.
- Trial name
- NCT03331718
- Testing
- PGA felt reinforcement
- Where
- Japan
- Volunteers
- 514 people
- Sponsor
- University of Toyama
Pancreatic Tumor
Differentiation Benign and Malignant Pancreatic Lesions
The MVIT-MLKA model, with its complex architecture combining CNNs and Transformers, excels in image feature extraction and capturing long-range dependencies.
- Trial name
- D (NCT06641947)
- Testing
- Whipple procedure
- Where
- China
- Volunteers
- 864 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Metastatic Colorectal Cancer, Liver Metastases
Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy
The primary objective of the study is to increase by 15% the complete macroscopic resection rate of predominantly liver metastases from metastatic colorectal cancer through combining systemic cetuximab and hepatic artery infusion…
- Conditions
- Metastatic Colorectal Cancer, Liver Metastases, Hepatic Lesions
- Trial name
- OPTILIV (NCT00852228)
- Testing
- IV cetuximab, HAI chronomodulated chemotherapy, HAI conventional chemotherapy
- Where
- 14 sites in Belgium, France and 2 more
- Volunteers
- 60 people
- Sponsor
- Association pour la Recherche sur le Temps Biologique et la Chronothérapie
Pancreatic Cancer, Neoplasm
Family and Personal History of Malignancy in Intraductal Papillary Mucinous Neoplasm (IPMN)
This is a retrospective observational study to determine the proportion of patients with a family history of pancreatic cancer and other malignancies among patients who have intraductal papillary mucinous neoplasm (IPMN).
- Trial name
- NCT01104077
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Columbia University
Stomach Neoplasm, Chronic Atrophic Gastritis
The Gastric HormonE BioMarkers of Preneoplastic Lesions Study
The goal of the study is to understand whether blood levels of hormones produced or metabolized in the stomach reflect the health of the stomach lining.
- Conditions
- Stomach Neoplasm, Chronic Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- GEM (NCT06085677)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pancreatic Cysts
Registry and Fluid Banking of Pancreatic Cystic Lesions
The purpose of this study is to follow patients, who have small mucinous cysts in the pancreas, prospectively over a 5-year period.
- Trial name
- NCT01769534
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Colonic Polyp, Colonic Neoplasms
Endoscopic Surveillance in Serrated Polyposis Syndrome and Low-risk of Advanced Neoplasia
The aim of the study is to determine if Serrated Poliposis Syndrome (SPS) patients with SPS criteria, with clearing phase achieved and without any advanced lesion or less than 5 relevant lesions at last colonoscopy have the same…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Cancer, Serrated Polyposis
- Trial name
- NCT04906343
- Testing
- Colonoscopy
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Hospital Universitario de Móstoles
Esophageal Lesion, Barrett Esophagus
Endoscopic Submucosal Dissection (ESD)
This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic submucosal dissection. All patients will receive standard of medical care and no experimental interventions will be performed.
- Conditions
- Esophageal Lesion, Barrett Esophagus, Gastrointestinal Lesions
- Trial name
- ESD (NCT05468008)
- Testing
- Endoscopic Submucosal Dissection
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- AdventHealth
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Benign Breast Disease
REGENERA Implant in Excised Non-Malignant Breast Lesions
The purpose of this First-in-Human pilot study is to evaluate the safety and performance of REGENERA breast implant in a selected cohort of patients with non- malignant breast lesions treated with excision or lumpectomy in whom…
- Trial name
- NCT04131972
- Testing
- REGENERA
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Tensive SRL
Neoplasms, Pancreatic Cancer
PET-CT in Diagnosis of Pancreatic Cystic Neoplasms
Preoperative diagnosis of pancreatic cystic lesions remains a difficult problem in clinical practice. At present, the treatment planning in pancreatic cystic neoplasms is significantly restricted by the limited preoperative…
- Trial name
- NCT01317836
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Turku University Hospital