Clinical trials: Gastrointestinal Lesions
Neoplasm, Pancreatic Cancer
Use of PET Imaging to Distinguish Malignant From Benign IPMN
Intraductal papillary mucinous neoplasm (IPMN) is a cystic pancreatic lesion that is a precursor to invasive pancreatic cancer. Differentiating whether an IPMN lesion is benign or malignant is critical, as the prognosis and…
- Trial name
- NCT01104116
- Testing
- [18F]-FDG PET/CT imaging
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Colorectal Adenocarcinoma Metastatic in the Liver, Liver Ablation
International Study on Treatment of Patients With Metastatic Colorectal Liver Lesions Patients With IRE
Procedural data will be recorded from patients with liver metastases from colorectal cancer who have received at least one course of systemic chemotherapy and who have been assessed by an appropriately constituted MDT (or…
- Conditions
- Colorectal Adenocarcinoma Metastatic in the Liver, Liver Ablation, Liver Cancer, Adult
- Trial name
- LIVERMET-IRE (NCT07191548)
- Testing
- Irreversible Electroporation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Angiodynamics, Inc.
Cancer of Pancreas, Pancreas Cyst
Tumour Regulatory Molecules in Early Pancreatic Cancer Detection
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis.
- Trial name
- TEM-PAC (NCT03536793)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Hepatocellular Carcinoma
The AI Prognostic Assessment and Pathological Basis Research of Early HCC After Minimally Invasive Treatment
The study evaluates artificial intelligence method based on multimodal magnetic resonance imaging (MRI) images and clinical data in preoperative prediction of prognosis in early hepatocellular carcinoma (HCC) patients treated…
- Trial name
- NCT04299919
- Testing
- Minimally invasive treatment, Hepatectomy
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Gastric Cancer, Precancerous Lesion
The Research of Constructing a Risk Assessment Model for Gastric Cancer Based on Machine Learning
Based on the gastric cancer database established earlier, this project explored the PG standard suitable for Chinese people, and further explored the establishment of machine learning model to stratify gastric cancer risk in the…
- Conditions
- Gastric Cancer, Precancerous Lesion, Mechine Learning
- Trial name
- NCT04957407
- Testing
- pepsinogen
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA)
In-Depth Characterisation of Biliary Strictures and Hepato-Pancreato-Biliary Focal Lesions for Development of New Technologies to Tackle Hepato-Pancreato-Biliary Cancers
Hepato-Pancreato-Biliary (HPB) cancers originating in the liver, bile ducts, pancreas, and gall bladder represent a rising global health challenge, with incidence doubling in the UK over the past decade.
- Conditions
- Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA), Cholangiocarcinoma, Cholangiocarcinoma Cancer
- Trial name
- Map HPB (NCT07206355)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Nottingham
Colorectal Cancer, Colorectal Adenoma
FIT and Fecal Calprotectin in Patients With Chronic Lower GI Symptoms
Chronic lower gastrointestinal (GI) symptoms, including lower abdominal pain, bowel habit change, bleeding per rectum, and abdominal bloating, are caused by functional gastrointestinal disorders (FGID) and organic intestinal…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colitis
- Trial name
- NCT05514561
- Testing
- Fecal calprotectin, Fecal immunochemical test
- Where
- Thailand
- Volunteers
- 1,007 people
- Sponsor
- Mahidol University
Crohn's Disease, Mucosal Inflammation
Assessment of Mucosal Activity to Improve the Prognosis of Patients With Crohn's Disease Treated With Immunosuppressants
This study will test that individualized treatment in patients with Crohn's Disease in remission or mild clinical activity under immunosuppressants may improve prognosis, rather than just treating flares.
- Trial name
- ADACAL (NCT01562951)
- Testing
- ADALIMUMAB
- Where
- 30 sites in Belgium, France and 1 more
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Pancreatic Neoplasms, Mediastinal Neoplasms
22G-Adapt vs 22G-Franseen Needle Biopsy in EUS-Guided Tissue Acquisition of Solid Lesions
The investigators conduct a prospective, multicenter, blinded, randomized controlled trial to compare the diagnostic value and safety of the 22G Adapt needle versus the 22G Franseen needle for histopathological evaluation of…
- Conditions
- Pancreatic Neoplasms, Mediastinal Neoplasms, Abdominal Neoplasm, Excluding Pancreas Neoplasm
- Trial name
- NCT07012694
- Testing
- 22G Franseen Needle Group, 22G Adapt Needle Group
- Where
- China
- Volunteers
- 576 people
- Sponsor
- Huazhong University of Science and Technology
Intraoperative Bleeding, Liver Diseases
GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery
This is a pre-market, prospective, randomized (1:1), multicenter, pivotal clinical investigation. The purpose of this investigation is to determine the clinical performance of GATT-Patch as compared with SURGICEL® Original for…
- Conditions
- Intraoperative Bleeding, Liver Diseases, Gallbladder Diseases, Hemorrhage, Surgical
- Trial name
- NCT05900037
- Testing
- GATT-Patch, SURGICEL® Original
- Where
- 6 sites in United States
- Volunteers
- 53 people
- Sponsor
- GATT Technologies BV
Adenocarcinoma of Head of Pancreas, Cholangio Carcinoma
Pancreatic Head and Peri-ampullary Cancer Laparoscopic vs Open Surgical Treatment Trial (PLOT)
The aim of this study is to compare the two surgical approaches namely laparoscopic pancreatoduodenectomy and open pancreatoduodenectomy for management of periampullary and pancreatic head cancers in terms of parameters like…
- Conditions
- Adenocarcinoma of Head of Pancreas, Cholangio Carcinoma, Duodenal Adenocarcinoma, Carcinoma of Ampulla of Vater
- Trial name
- PLOT (NCT02081131)
- Testing
- Open surgery, Laparoscopic surgery
- Where
- India
- Volunteers
- 64 people
- Sponsor
- GEM Hospital & Research Center
Gastrointestinal Neoplasms, Benign Neoplasm of Intestinal Tract
Clinical Outcomes of the Endoscopic Resection of Premalignant and Malignant Gastrointestinal Lesions
To evaluate clinical outcome for patients receiving treatment of suspected premalignant and malignant gastrointestinal lesions at Interventional Endoscopy Services. The primary outcome is curative endoscopic resection.
- Trial name
- NCT01750619
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- California Pacific Medical Center Research Institute
Anal Cancer, High-grade Squamous Intraepithelial Lesion
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
The randomized phase of the trial compared topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immunodeficiency virus (HIV) and high-grade squamous intraepithelial lesions (HSIL).
- Conditions
- Anal Cancer, High-grade Squamous Intraepithelial Lesion, HIV Infection, Human Papilloma Virus Infection
- Trial name
- ANCHOR (NCT02135419)
- Testing
- imiquimod, fluorouracil, infrared photocoagulation therapy
- Where
- 25 sites in United States, Puerto Rico
- Volunteers
- 4,446 people
- Sponsor
- AIDS Malignancy Consortium
Pancreatic Cancer, Lymphadenopathy
Beacon BNX™ Endoscopic Ultrasound (EUS)-Needle vs SharkCore™ Needle
The primary objective of this proposed prospective randomized, multi-center study is to evaluate the capability of the new 22G SharkCore™ needle to obtain tissue specimens and to compare its performance against the standard 22G…
- Conditions
- Pancreatic Cancer, Lymphadenopathy, Cholangiocarcinoma
- Trial name
- NCT02872831
- Testing
- 22G SharkCore™ needle, 22G BNX EUS-FNA Needle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Plaque Psoriasis, Crohn's Disease
Adalimumab-psoriasis and Small Bowel Lesions
This study will determine the prevalence of small bowel lesions suggestive of Crohn's disease (CD) in patients with moderate to severe plaque psoriasis using capsule endoscopy.
- Trial name
- NCT01556672
- Testing
- Adalimumab, Capsule endoscopy
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Innovaderm Research Inc.
Adenoma Colon, Colon Adenoma
Conventional Endoscopic Mucosal Resection Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial
Comparing the complete resection rate and subsequent adenoma recurrence rate at surveillance colonoscopy of 15-40mm laterally spreading adenomas for conventional EMR vs. cold snare EMR.
- Conditions
- Adenoma Colon, Colon Adenoma, Colon Cancer
- Trial name
- NCT04138030
- Testing
- Conventional Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- Western Sydney Local Health District
Adenocarcinoma Colon
Study for the Efficacy and Security Analysis in the Protection of Ileocolic Anastomosis Conducted in Laparoscopic Right Hemicolectomy Because of Colon Cancer, Using a NHS-PEG Coated Collagen Patch.
The aim of this study is to analyse the effectiveness and security in the prevention of anastomotic leakage by protecting the ileocolic anastomosis with a reabsorbable NHS-PEG collagen patch.
- Trial name
- ANASTOPATCH (NCT04109105)
- Testing
- NHS-PEG coated collagen patch
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Esophageal Cancer
Prospective Evaluation of a New Covered Metal Stent for Malignant Lesions of the Esophagus
In this study, a newly designed and FDA approved fully covered metal stents will be used to palliate 20 patients with malignant lesion of the esophagus.
- Trial name
- NCT01301495
- Testing
- HANAROSTENT TM covered Esophageal Stent
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
The Cohort Study of Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
Endoscopic Submucosal Dissection (ESD) is currently the main method of treatment of early esophageal cancer and precancerous lesions.
- Trial name
- NCT03377972
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Polyp, Colorectal Neoplasms
Real-time AI-assisted Endocyroscopy for the Diagnosis of Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and early and…
- Trial name
- NCT06791395
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- 3 sites in China
- Volunteers
- 570 people
- Sponsor
- The First Hospital of Jilin University