Clinical trials: Gastrointestinal Lesions
Bladder Cancer, Cervical Cancer
Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking
RATIONALE: Varenicline, the nicotine patch, and nicotine gum help people stop smoking. It is not yet known whether varenicline is more effective than the nicotine patch given together with nicotine gum in helping smokers quit…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00790569
- Testing
- nicotine, varenicline
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- Butler Hospital
Pancreatic Neoplasms, Pancreatitis
Contrast EUS of the Pancreas
RATIONALE: Endoscopic Ultrasound (EUS) is the leading method to evaluate the pancreas but there may be difficulty characterizing small lesions, tumors which are not adenocarcinomas and neoplasia in the setting of pancreatitis.
- Conditions
- Pancreatic Neoplasms, Pancreatitis, Pancreatic Cyst
- Trial name
- NCT02863770
- Testing
- EUS enhanced with contrast to evaluate pancreas
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Esophagogastroduodenoscopy
AQCS for Detection of Early Cancer and Precancerous Lesions on Upper Gastrointestinal Tract
The purpose of our study was to assess the performance of esophagogastroduodenoscopy automatic quality-control system in real-time quality control of EGD.
- Trial name
- NCT04720924
- Testing
- Computer-aided Real-time Automatic Quality-control System
- Where
- 6 sites in China
- Volunteers
- 1,840 people
- Sponsor
- Shandong University
Pancreatic Tumors
Standard Versus Fanning Techniques for Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA)
Endoscopic Ultrasound (EUS)-guided biopsy is the most ideal technique for evaluating a growth in the pancreas. EUS-guided biopsies yield a definitive diagnosis in greater than 80% of cases.
- Trial name
- NCT01501903
- Testing
- Standard, Fanning
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Shyam Varadarajulu
Pancreatic Ductal Adenocarcinoma, Pancreatitis, Chronic
Artificial Intelligence in EUS for Diagnosing Pancreatic Solid Lesions
We aim to develop an EUS-AI model which can facilitate clinical diagnosis by analyzing EUS pictures and clinical parameters of patients.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatitis, Chronic, Pancreatic Neuroendocrine Tumor, Autoimmune Pancreatitis
- Trial name
- NCT05476978
- Testing
- EUS-AI model
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Huazhong University of Science and Technology
Esophageal Neoplasm, Esophageal Polyp
Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions
Both Baylor St Luke's Medical Center and Mayo Scottsdale are considered endoscopic submucosal dissection (ESD) centers of excellence.
- Conditions
- Esophageal Neoplasm, Esophageal Polyp, Endoscopic Submucosal Dissection, Bipolar Electrocautery
- Trial name
- NCT06476678
- Testing
- Speedboat™ Ultraslim
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Neoplasms, Colorectal
Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Lesions.
EMR and ESD are both effective and safe and are associated with a very low risk of procedure related mortality when performed for colorectal laterally spreading lesions (LSL).
- Trial name
- intERsection (NCT04593407)
- Testing
- Endoscopic mucosal resection (EMR), Endoscopic submucosal dissection (ESD)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- José Carlos Marín Gabriel
Microscopic Colitis, Colorectal Cancer
Mucosa Adherent Intestinal Microbiome in Microscopic Colitis and Colorectal Cancer
Microscopic colitis (MC) is an inflammatory bowel disease characterized by chronic non-bloody watery diarrhoea and a macroscopically normal colonic mucosa upon endoscopic exploration (colonoscopy).
- Conditions
- Microscopic Colitis, Colorectal Cancer, Colon Adenoma
- Trial name
- CMBACT (NCT06172647)
- Testing
- Colonoscopy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Gastric Cancer, Precancerous Lesion of Digestive Tract
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution.
- Conditions
- Gastric Cancer, Precancerous Lesion of Digestive Tract, Extrachromosomal DNA
- Trial name
- NCT05956847
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colorectal Neoplasms
Comparison of Diagnostic Accuracy for Predicting Histology of Colorectal Lesions
Chromoendoscopy (indigo carmine or acetic acid) and Narrow Band Imaging (NBI) could make accurate evaluation in predicting of invasive depth of colorectal neoplasia. NBI could be the first choice.
- Trial name
- NCT01521091
- Where
- China
- Volunteers
- 565 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Esophageal Squamous Cell Carcinoma
PPIO-008 Tislelizumab Combined With S-1 in Patients With ypT+N0 ESCC After Radical Resection With Neoadjuvant STUDY
To explore the safety and efficacy of Tegafur combined with tislelizumab in patients with esophageal squamous cell carcinoma with residual primary lesion and node-negative after radical resection following neoadjuvant…
- Trial name
- NCT06354140
- Testing
- Tegafur
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Hepatocellular Carcinoma
Fusion Imaging Contrast-enhanced Ultrasound LI-RADS
CEUS LI-RASD apply to lesion visible at precontrast ultrasound but not the lesion invisible. Fusion imaging can use to invisible lesions at precontrast ultrasound in clinical practice.
- Trial name
- NCT04955119
- Testing
- Fusion imaging contrast-enhanced ultrasound
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Tianjin Third Central Hospital
Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
The Cohort Study of Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
Endoscopic Submucosal Dissection (ESD) is currently the main method of treatment of early esophageal cancer and precancerous lesions.
- Trial name
- NCT03377972
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Colon Adenoma, Colonic Polyp
AI-assisted Detection of Missed Colonic Polyps
A prospective validation of real time deep learning artificial intelligence model for detection of missed colonic polyps
- Conditions
- Colon Adenoma, Colonic Polyp, Colon Cancer
- Trial name
- NCT04227795
- Testing
- Artificial intelligence-Assisted real time colonoscopy
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong
Pancreatic Cancer, Pancreatic Cystic Lesions
Predicting Cancer in Pancreatic Cystic Lesions Through Artificial Intelligence
This international, multicenter retrospective study aims to develop a deep learning (DL)-based predictive model to identify malignant transformation in pancreatic cystic lesions, improving upon current clinical guidelines.
- Trial name
- NCT06954753
- Testing
- Pancreatic surgery
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colonic Disease
Efficacy, Safety and Recurrence After Cold-EMR Plus APC for Large Colonic Lesions
This prospective observational study aims to evaluate the efficacy, safety and recurrence of cold-snaring for large colonic lesions combined with argon plasma coagulation of the resection bed.
- Trial name
- EMR+APC (NCT06435377)
- Testing
- Procedure: Cold EMR + APC
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Clinico Humanitas
Pancreatic Cystic Lesion, Mucinous Cystadenoma of Pancreas
Management of Pancreatic Cystic Lesions Using Artificial Intelligence Based on EUS and Multimodal Data
The primary objective is to construct a multimodal AI model (Cyst-AI) based on EUS images and clinical data such as imaging features(CT or MRI) and laboratory tests to assist endoscopists in the diagnosis of pancreatic cystic…
- Conditions
- Pancreatic Cystic Lesion, Mucinous Cystadenoma of Pancreas, Intraductal Papillary Mucinous Neoplasm of Pancreas, Pseudocyst Pancreas
- Trial name
- NCT07463872
- Testing
- Cyst-AI model
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Huazhong University of Science and Technology
Irritable Bowel Syndrome
IBS Skin Patch Test Food Allergy Study
Participants with IBS are skin patch tested (no needles) to 80 different foods and food additives, compounded for patch testing, in search of food allergies. The testing requires 3 office visits within a 4 or 5 day period.
- Trial name
- NCT06288672
- Testing
- True avoidance diet
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- IBS-80, LLC
Irritable Bowel Syndrome (IBS)
Diet and Motility in IBS
The goal of this observational study is to identify factors that influence symptoms in children with irritable bowel syndrome (IBS), to find ways to make diet treatments work better and possibly create personalized plans to help…
- Trial name
- IBS (NCT07283341)
- Testing
- Wireless Patch System
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia