Clinical trials: Gastrointestinal Lesions
Colorectal Neoplasms, Colonic Polyps
Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study
We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Colorectal Cancer
- Trial name
- NBI (NCT01310699)
- Testing
- Olympus Colonoscope CFHQ190AL
- Where
- 3 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Anal Cancer
Assessing Drivers and Barriers to Follow-Up Screening for Anal Cancer in Men Who Have Sex With Men
This study is designed to identify barriers that prevent men who have sex with men from receiving doctor-recommended annual follow-up screenings for anal cancer.
- Trial name
- NCT00501306
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Laser Surgery Care
Liver Cancer
Evaluation of the Signa Excite 3.0 T MRI Excite for Detection and Characterization of Liver Lesions
Primary Objective: 1. To compare the efficacy of 1.5T vs. 3T T1 and T2-weighted MR images sequences for the detection and evaluation of liver lesions.
- Trial name
- NCT00527891
- Testing
- Signa Excite 3.0 T MRI Scan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Neoplasms, Gastric Cancer
The EpiGASTRIC/EDGAR Project: New Strategies for the Early Detection and Prevention of Gastric Cancer
This study is a multicenter, prospective cohort study, which are planned to enroll at least 600 patients who diagnosed the primary gastric cancer (GC); around 50 patients with premalignant gastric lesions (PGLs) and early gastric…
- Conditions
- Gastric Neoplasms, Gastric Cancer, Gastric Lesion
- Trial name
- NCT05551416
- Testing
- Identification of risk factors, Characterization of premalignant gastric lesions, Identification of biomarkers
- Where
- 15 sites in Spain
- Volunteers
- 1,200 people
- Sponsor
- EDUARDO ALBENIZ
Upper Gastrointestinal Disorder
Upper Endoscopy in Ulcerative Colitis Patients in Assiut University
Aim of study: Primary Outcomes: Patients with ulcerative colitis-associated upper gas- trointestinal inflammation may require specific treat- ment for the gastroduodenal lesions.
- Trial name
- NCT06092593
- Testing
- Upper endoscopy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Anxiety, Pancreatic Cancer
Graphic Novel for Patients Undergoing EUS-FNB
Endoscopy with endoscopic ultrasound (EUS) is a primary technique for diagnosing and treating severe pancreatic disorders. However, the procedure can cause fear and anxiety in patients, especially when a biopsy is involved.
- Conditions
- Anxiety, Pancreatic Cancer, Pancreatic Cystic Lesions, Stress
- Trial name
- NCT06268106
- Testing
- Graphic novel visualization
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Pancreatic Cyst, Molecular, Chemical Analysis of Cystic Fluid
Confirmation of Association Between Cystic Fluid Analysis With Pancreatic Cystic Lesions
Through a comprehensive analysis of the pancreatic cystic fluid analysis, the role of the cystic fluid analysis is confirmed in terms of accurate diagnosis of pancreatic cysts, appropriate prediction of treatment response, and to…
- Trial name
- NCT05497271
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Liver Cancer, Adult
The Diagnostic Efficacy and Lesion Detection Advantages of 18F-FDG PET/Contrast-enhanced MRI in Malignant Liver Lesions
Liver disease, a major global health burden, ranges from mild dysfunction to severe conditions like cirrhosis and hepatocellular carcinoma (HCC), the fifth most common cancer.
- Trial name
- NCT07055048
- Volunteers
- 60 people
- Sponsor
- Shanghai East Hospital
Pancreatic Neoplasms
Rapid On-Site Evaluation (ROSE) by Endosonographer: for Whom, When and by Whom?
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a highly sensitive and specific method in diagnosing solid pancreatic lesions.
- Trial name
- NCT04002778
- Testing
- Fine needle aspiration, Rapid on-site evaluation
- Volunteers
- 66 people
- Sponsor
- Universidade Federal do Rio de Janeiro
HSIL, High-Grade Squamous Intraepithelial Lesions, Human Papilloma Virus Infection
Study of Topical ABI-1968 in Subjects With Precancerous Anal Lesions Resulting From Human Papillomavirus (HPV) Infection
This study evaluates the use of ABI-1968, a topical cream, in the treatment of anal precancerous lesions in adults with and without human immunodeficiency virus (HIV) infection.
- Conditions
- HSIL, High-Grade Squamous Intraepithelial Lesions, Human Papilloma Virus Infection, HIV Infection, Anal Cancer
- Trial name
- NCT03202992
- Testing
- ABI-1968
- Where
- 6 sites in United States, Australia
- Volunteers
- 57 people
- Sponsor
- Antiva Biosciences
Pancreatic Cyst
Comparison Between Dual Energy/Subtraction CT With MRI for the Identification of Predictors of Malignancy in Cystic Pancreatic Lesions
Cystic pancreatic lesions are increasingly detected incidentally in imaging studies, reportedly in up to 45% of the abdominal Magnetic Resonance (MR) examinations.
- Trial name
- NCT03320733
- Testing
- Dual energy CT scan with subtraction imaging
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Perforated Peptic Ulcer
Management of Perforated Peptic Ulcer
Perforated peptic ulcer (PPU) is a common surgical emergency. Exploratory laparotomy and repair with the omental patch are routine surgical intervention till now.
- Trial name
- NCT05699616
- Testing
- Repair of perforated peptic ulcer
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- South Valley University
Lung Non-Small Cell Carcinoma, Metastatic Colorectal Carcinoma
Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study
This study compares the outcomes and safety of two standard treatment options called microwave ablation and surgical wedge resection in patients with non-small cell lung cancer, sarcoma and colorectal cancer that has spread to…
- Conditions
- Lung Non-Small Cell Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Sarcoma, Stage I Lung Cancer AJCC v8
- Trial name
- NCT04430725
- Testing
- Computed Tomography with Contrast, Microwave Ablation, Questionnaire Administration
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- M.D. Anderson Cancer Center
Neoplasms, Biliary Stricture
The Diagnostic Value of Combinatory EUS and ERCP in Unclear Lesions
ERCP with brush cytology has a poor to moderate accuracy in unclear biliary lesions. Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) for cytology may override some of these shortcomings.
- Conditions
- Neoplasms, Biliary Stricture, Biliary Tract Neoplasms, Biliary Tract Diseases
- Trial name
- NCT03504293
- Testing
- Combinatory EUS and ERCP
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Sahlgrenska University Hospital
Colonic Neoplasms
Comparison of MORbidity of Submucosal DIssection Resection of Giant cOlon Lesions Versus Surgery: a National Multicenter Study (MORDIGO)
Propose a one-piece endoscopic resection such as endoscopic submucosal dissection (ESD) rather than surgery for benign lesions and superficial T1 cancers colorectal cancers offers comparable efficacy with better tolerability.
- Trial name
- MORDIGO (NCT06371898)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Pancreatic Cancer, Pancreatic Cystic Lesions
Trial Assessing Roux-en-Y Anastomosis of the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
The objective is to clarify Roux-en-Y anastomosis of the pancreatic stump decreases pancreatic fistula following distal pancreatectomy, compared with stapling closure of the pancreatic stump.
- Conditions
- Pancreatic Cancer, Pancreatic Cystic Lesions, Chronic Pancreatitis, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01384617
- Testing
- Stapling closure of the pancreatic stump, Roux-en-Y anastomosis of the pancreatic stump
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Wakayama Medical University
Crohn Disease (CD)
Virtual hIStology of Crohn's Disease Ex-vivo Resected Anatomical Lesions
Crohn's disease is a chronic, incurable inflammatory bowel disease with an unpredictable course, characterized by alternating remission and inflammatory flares.
- Trial name
- VISCERAL (NCT07413653)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis
Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease
Study Hypothesis UC Disease affects the colon. PillCam IBD may be used for visualization of the colon mucosa in UC Disease patients.
- Trial name
- UC (NCT02025777)
- Testing
- Capsule Endoscopy
- Where
- 2 sites in Israel, Spain
- Volunteers
- 30 people
- Sponsor
- Medtronic - MITG
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Crohn Disease
Description of Perianal Lesions in a Cohort of Crohn's Disease Patients
The perianal lesions (LAP) specific for Crohn's disease have been reported in 1938, six years after the first cases of luminal disease.
- Trial name
- LAPCROHN (NCT02899013)
- Testing
- No intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Hôpital Saint-Joseph