Clinical trials: Gastrointestinal Microbiota
Crohn's Disease
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease
Background VSL#3 has been reported as an effective adjuvant therapy both in inducing and maintaining remission in pediatric patients affected by Ulcerative Colitis.
- Trial name
- NCT01632462
- Testing
- VSL#3
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Crohn Disease, Spondyloarthritis
Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA).
- Trial name
- MICROSPA (NCT03983473)
- Testing
- Microbiota Sequencing
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Insomnia, Sleep Disturbance
Exploration of Relationships Between Sleep, Gut Health and Cognition
Our study aims to build on emerging evidence showing relationships between gut health, sleep and brain functions. To achieve this, our study aims to test the feasibility of using non-pharmacological interventions: a…
- Trial name
- NCT05315986
- Testing
- Saffr'Inside; 30mg, Enhanced Sleep Education
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Overweight/Obese Adults
Effects of the Bifidobacterium Longum BL21 on BMI, Metabolic Indicators, and Gut Microbiota in Overweight/Obese Adults
The goal of this study is to investigate the effects of Bifidobacterium longum subspecies BL21 on BMI, metabolic indicators, and changes in gut microenvironment microbiota in overweight/obese adults.
- Trial name
- NCT06140641
- Testing
- Probiotics
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori Eradication
Effect of Probiotics on Helicobacter Pylori Eradication
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple…
- Trial name
- NCT04034641
- Testing
- Bifidobacterium tetrad live bacteria tablet plus Helicobacter pylori quadruple eradication therapy
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Hangzhou Grand Biologic Pharmaceutical, Inc.
Hemodialysis, Probiotics
Effect of Probiotic and Synbiotic Administration on Nutritional Status in Hemodialysis Patients
This study aims to investigate the impact of probiotics and synbiotics on the nutritional status of patients with end-stage kidney disease (ESRD) who are undergoing hemodialysis.
- Conditions
- Hemodialysis, Probiotics, Synbiotics, Nutritional Status
- Trial name
- ProSyn-HD (NCT06891105)
- Testing
- Lactogemikan (Probiotic Supplement), Lactogemikan + Prebiotic Fiber (Synbiotic Supplement)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Non-Alcoholic Fatty Liver Disease, Gastrointestinal Microbiome
Exercise Study in Subjects With NAFLD
Non-Alcoholic Fatty Liver Disease is the most common cause of chronic liver diseases. The benign non-alcoholic fatty liver, characterized by excessive fat accumulation, can evolve into non-alcoholic steatohepatitis and liver…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Gastrointestinal Microbiome, Exercise
- Trial name
- BestTreat (NCT03995056)
- Testing
- high-intensity aerobic interval training
- Where
- Finland
- Volunteers
- 49 people
- Sponsor
- University of Eastern Finland
Early Cirrhosis
Clinical Food Study to Evaluate the Effect of KB174 on the Gut Microbiome in Subjects With Well-compensated Cirrhosis
This randomized, double-blind, controlled, clinical food study aims to explore KB174, a novel mixture of oligosaccharides, and maltodextrin, an easily digestible polysaccharide, on gut microbiome structure and function in…
- Trial name
- NCT03855956
- Testing
- KB174, Maltodextrin
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Kaleido Biosciences
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Non-Alcoholic Fatty Liver Disease, Obesity
Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study
Non alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the U.S. (Browning, et al., 2004), ranging from steatosis to end-stage liver disease.
- Trial name
- NCT03339245
- Testing
- Fructose Solution (75 Grams), Glucose Solution (75 grams)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Moderate Acute Malnutrition
Microbiota Directed Food for Children With Moderate Acute Malnutrition
Moderate acute malnutrition (MAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months.
- Trial name
- NCT06305442
- Testing
- Microbiota-Directed Food, Ready-to-Use Supplementary Food
- Where
- Bangladesh
- Volunteers
- 230 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Liver Cirrhosis
Fecal Microbiota Transplantation in Decompensated Cirrhosis
Cirrhosis of the liver is the culmination point of long-standing chronic liver disease hallmarked by the cardinal features of liver fibrosis and portal hypertension.
- Trial name
- NCT04842539
- Testing
- Fecal Microbiota Transplantation, Standard of care
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hyperlipidemia
Ezetimibe and Orlistat Affect the Intestinal Flora of Hyperlipidemia.
At present,the prevalence of hyperlipidemia in Chinese adults is 40.40%,which is related to atherosclerotic cardiovascular disease and diabetes independent risk factors,while increasing the risk of cancer.Lipid metabolism affects…
- Trial name
- NCT03884127
- Testing
- Ezetimibe 10mg, Orlistat 120 MG
- Volunteers
- 58 people
- Sponsor
- Fifth Affiliated Hospital of Xinjiang Medical University
Healthy Adults
Enteral Nutrition and Immune Proteins Study
Eligible healthy adults who consent to take part in the study will be randomised to receive either a specialised milkshake for all of their normal daily diet (exculsive enteral nutrition, EEN) or the same specialised milkshake…
- Trial name
- ENIP (NCT06828094)
- Testing
- enteral nutrition
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Metabolic Disease, Injury of Gastrointestinal Tract
The Effect of Whole Grain on Gut Microbiome and Metabolic Health
Objective: To identify how specific changes of the whole grain content in the diet affect the host-gut microbiome interactions with implications for metabolic health .
- Trial name
- 3G (NCT01731366)
- Testing
- Whole grain, Refined grain
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Colorectal Cancer (MSI-H), Malnutrition (Calorie)
Dietary Fiber and Probiotics in Advanced Colorectal Cancer
This single-center, prospective, randomized controlled trial was conducted to evaluate the efficacy of a 12-week combined dietary fiber and probiotic supplementation on gut microbiota, immune function, nutritional status, and…
- Trial name
- NCT07194954
- Testing
- Combined Dietary Fiber and Probiotics., Standard Nutritional Support
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Hospital of Hebei Medical University
Fermented Vegetable Intake, Fermented Vegetable Acceptability
Fermented Vegetables and Gut Microbiome Pilot Study
The purpose of this research is to determine the effect of fermented vegetable consumption on LAB abundance and tolerability of the intervention in young healthy people before conducting a full RCT with older participants.
- Conditions
- Fermented Vegetable Intake, Fermented Vegetable Acceptability, Gut Health, Gut Microbiome
- Trial name
- NCT06883994
- Testing
- Fermented vegetable intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Irritable Bowel Syndrome
Precision Pain Self-Management in Young Adults With Irritable Bowel Syndrome
This pilot project will provide foundational information about the contextual factors of irritable bowel syndrome (IBS) related pain (pain catastrophizing, perceived stress, reactivity pain sensitivity, genetic and microbiome) on…
- Trial name
- IBS-SM (NCT03332537)
- Testing
- Personalized IBS Pain SM
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Connecticut
Gluten Sensitivity
Effects of Ancient Grains-based Diet in a Closed Community
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease or wheat…
- Trial name
- NCT03020511
- Testing
- Ancient wheat flours
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Endothelial Dysfunction, Aging
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, a major initial step in the development of atherosclerosis.
- Trial name
- NCT03824041
- Testing
- Aronia full spectrum - half dose, Aronia full spectrum - full dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colorado State University
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