Clinical trials: Gastrointestinal Microbiota
Rhinitis, Allergic, Asthma
Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Allergic diseases, including allergic reactions of respiratory tract and skin, are often triggered by mast cell degranulation mediated by allergen-specific IgE and chronic inflammation of target organs, which are involved in a…
- Conditions
- Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria
- Trial name
- NCT04938700
- Testing
- probiotics, conventional medical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity (ThreeBees)
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- ThreeB (TB) (NCT06799364)
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects., 28-days consumption of Product B in 45 to 60-year-old healthy subjects., 28-days consumption of Control product in 45 to 60-year-old healthy subjects.
- Where
- 3 sites in France
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Type 1 Diabetes, Obesity
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications.
- Trial name
- NCT05414409
- Testing
- Metformin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Heba M. Ismail
Health, Obesity Type 2 Diabetes Mellitus
Safety and Tolerability Evaluationof Phascolarcobacterium Faecium
The goal of this interventional study is to assess the safety and tolerability of the daily administratrion of bacterium Phascolarctobacterium faecium in healthy adults with normal weight, and in individuals with overweight and…
- Conditions
- Health, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- NCT07285317
- Testing
- Bacterium P. faecium
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Healthy
Pilot Study on the Effect of a XOS95 on the Human Gut Microbiome
The purpose of this clinical trial is to assess the efficacy of a novel prebiotic, XOS95, at two different dosages, in comparison to a placebo by assessing shifts in microbial populations after 8 weeks of supplementation…
- Trial name
- NCT03074019
- Testing
- Xylooligosaccacharide, Maltodextrin
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Prenexus Health
Pregnancy Related, Pregnancy Loss
Microbiome and Malnutrition in Pregnancy
This study is being conducted to investigate how a mother's nutritional status and her gut microbiome during pregnancy contribute to the birth outcomes and health of her baby.
- Conditions
- Pregnancy Related, Pregnancy Loss, Pregnancy Complications, Pregnancy; Parasitic Disease
- Trial name
- MMIP (NCT04992104)
- Where
- 2 sites in Canada
- Volunteers
- 800 people
- Sponsor
- The Hospital for Sick Children
Metabolic Dysfunction-associated Steatotic Liver Disease
Fecal Microbiota Analysis of PNPLA3 Polymorphism in Hispanic Patients With MASLD
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common cause of liver disease worldwide. The condition is defined by fat accumulation exceeding 5% of liver weight not explained by at-risk alcohol…
- Trial name
- MPM (NCT06495333)
- Where
- Puerto Rico
- Volunteers
- 100 people
- Sponsor
- Fundacion de Investigacion Science and Education
Healthy Lifestyle
Improving Wellbeing Through the Brain-Gut-Microbiota Axis
Well-being is a state defined as the optimal psychological functioning and the experience associated with it, integrating physical and subjective factors.
- Trial name
- IBMA (NCT04823533)
- Where
- Chile
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Dysbiosis, Prophylaxis
Lactobacillus Reuteri DSM 17938 in Gut Microbiota Development in Infant Born by Caesarean Section
The aim of this study is to assess influence of probiotic Lactobacillus reuteri DSM 17938 on formation of gut microbiota in infant born by Caesarean section.
- Trial name
- NCT03675048
- Testing
- BioGaia Protectis drops
- Where
- Russia
- Volunteers
- 97 people
- Sponsor
- BioGaia AB
Crohn Disease
Fecal Microbiota Transplantation as the First-line Treatment in Active Pediatric Crohn's Disease
To explore the safety and effectiveness of repeated and multiple fecal microbiota transplantations (FMTs) plus partial enteral nutrition (PEN) as a first-line treatment for active Crohn's disease (CD) in children.
- Trial name
- FMT (NCT05321758)
- Testing
- Fecal Microbiota Transplantation, Immunosuppressive Agents
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease
Probiotic on Type 2 Diabetes and Chronic Obstruction Pulmonary Disease
This trial is a randomized, double-blind, parallel placebo clinical trial, the purpose of which is to investigate whether the adjuvant therapy of using probiotics during the treatment of diabetic patients can decrease blood sugar…
- Trial name
- NCT05492448
- Testing
- L. salivarius AP-32 and L. reuteri GL-104, L. reuteri GL-104
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Glac Biotech Co., Ltd
Bloating, Rifaximin
Rifaximin Treatment in Bloating Predominant Functional Bowel Disorders
This randomized, double-blind, placebo-controlled trial will evaluate the effects of a 14-day course of rifaximin on bloating symptoms, gut microbiota, microbial metabolites, and intestinal gases in adults with Rome V irritable…
- Conditions
- Bloating, Rifaximin, Functional Bowel Disorder, Irritable Bowel Syndrome
- Trial name
- NCT07522255
- Testing
- Rifaximin (drug)
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- Mahidol University
Spinal Cord Injury
Fermented Foods and Bowel Health in SCI
The goal of this clinical trial is to learn whether consuming a high fermented food diet improves bowel function and gut health in adults with chronic spinal cord injury (SCI).
- Trial name
- NCT07640152
- Testing
- fermented foods, Control diet, Sitz Marker Test
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Short Bowel Syndrome (SBS)
Role of the Microbiota in Intestinal Adaptation During Short Bowel Syndrome
During the first years following intestinal resection, spontaneous physiological adaptations occur in patients with short bowel syndrome (SBS), allowing improvement of the absorptive capacity of the remaining intestine.
- Trial name
- AdMIR (NCT07530055)
- Testing
- collection of blood and stool/chyme and intestinal biopsy
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Use, Opioid Use Disorder
Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate.
This study will aim to investigate the gut microbiota in Egyptian patients with opioid use disorders and correlate microbiota bacterial abundance with clinical data.
- Conditions
- Opioid Use, Opioid Use Disorder, Opioid Dependence
- Trial name
- NCT06231849
- Testing
- stool analysis
- Volunteers
- 52 people
- Sponsor
- Assiut University
Acute Myeloid Leukemia, Cachexia
Investigation of the Gut Microbiota in Patients With Acute Myeloid Leukemia
This cohort study aims to investigate the composition and activity of the gut microbiota of patients newly diagnosed for acute myeloid leukemia (AML), in relationship with their food habits and cachectic hallmarks.
- Trial name
- MicroAML (NCT03881826)
- Testing
- collection of clinical data and biological samples
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Obesity
Modifying Diet to Improve Gut Microbiome
The investigators will conduct a 2-arm randomized controlled pilot, feasibility feeding study in which 28 participants will be randomized to receive either a calorie-restricted Dietary Approaches to Stop Hypertension (DASH) diet…
- Trial name
- NCT03924778
- Testing
- DASH diet, standard American diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gut Microbiome, Inflammation
Salmon Intake and Gut Health in Adults
The overall objective of this project is to determine the interplay of salmon as a whole food and its bioactive compound astaxanthin on gut microbiome, fecal metabolome, and inflammation in obese prediabetic individuals.
- Trial name
- NCT04792216
- Testing
- Wild Salmon, Farmed Salmon
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Obesity
Environmental Health Effects on Your Physiology
This study evaluates the associations between exposure to air pollutants, green space, and the gut microbiome and metabolome.
- Trial name
- HYPHY (NCT03986814)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Boulder
Cancer of Head and Neck, Nutrition Aspect of Cancer
The Gut Microbiome As an Indicator of Readiness for Head & Neck Cancer Surgery
The purpose of this study is to understand how a pre-operative nutritional intervention alters the gut microbiome and improves outcomes after major head and neck cancer surgery.
- Trial name
- NCT05061316
- Testing
- Nestlé Impact Advanced Recovery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
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