Clinical trials: Gastrointestinal Microbiota
Low Birth Weight Infants
The Influence by Dietary Human Milk Oligosaccharide in Low Birth Weight Infants
This study aims to investigate the concentration of various growth factors and cytokines in blood, and to examine the gut microbiota of low birth weight infants fed with formulas with or without Human Milk Oligosaccharide (HMO)…
- Trial name
- NCT05203900
- Testing
- Infant formula with Human Milk Oligosaccharide, Infant formula without Human Milk Oligosaccharide
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Meiji Co., Ltd.
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Obesity
A Pilot Trial of Nabilone for the Treatment of Obesity
Obesity is a serious health problem which increases the likelihood of developing other life-changing medical conditions. Despite increasing knowledge about the neural and metabolic basis of obesity, the development of effective…
- Trial name
- NCT04801641
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Irritable Bowel Syndrome
The Effects of Laxative-probiotic Sequential Treatment in the Irritable Bowel Syndrome Patients
the laxative-probiotic sequential treatment might reduce the symptoms of IBS and alter the fecal microbiota of the patients in a more robust manner .
- Trial name
- NCT02254629
- Testing
- Probiotic Clostridium Butyricum, Laxative Polyethylene Glycol
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shandong University
Healthy Diet, Gastrointestinal Microbiome
Study the Effect of Water Kefir Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the water kefir consumption. The main questions are to evaluate the potential probiotic drink can have beneficial effect on the gut microbiota.
- Conditions
- Healthy Diet, Gastrointestinal Microbiome, Probiotics
- Trial name
- NCT05657730
- Testing
- Water Kefir beverage
- Where
- Sweden
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lund University
Acute Pancreatitis
FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) works to prevent infections complications in patients in the late phase of moderately severe or severe acute pancreatitis.
- Trial name
- NCT07464392
- Testing
- Fecal Microbiota Transplantation
- Where
- 12 sites in China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Inflammatory Marker, Gut Microbiome
The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink
Through empirical research evaluating the effects of "JING SI HERBAL TEA LIQUID PACKETS" and "JING SI HERBAL TANG HENG POWDER DRINK" as adjunctive treatments for various cardiovascular diseases, we aim to provide sufficient…
- Conditions
- Inflammatory Marker, Gut Microbiome, Trimethylamine N-oxide, HbA1c
- Trial name
- NCT06522412
- Testing
- JING SI HERBAL TEA LIQUID PACKETS, JING SI HERBAL TANG HENG POWDER DRINK
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Microbial Colonization, Antibiotic Side Effect
Autoflor -Lyophilized Capsulated Autological FMT to Restore Gut Microbiome After Treatment With Antibiotics
In this clinical trial, our aim is to assess the effect of auto-FMT (Fecal microbiome transplantation) on the intestinal microbiota, after a course of antibiotics. 30 healthy adults are recruited.
- Trial name
- FMT (NCT06250413)
- Testing
- FMT, Amox Clav
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Otto Helve
Metabolism
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.
- Trial name
- NCT04255368
- Testing
- Water-soluble choline, Fat-soluble choline, No choline control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Utah State University
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Inflammatory Bowel Diseases
Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide .
- Trial name
- NCT06591013
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Kidney Failure, Chronic
Effects of Probiotics on the Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to investigate the effects of oral administration of probiotics on the metabolism of uremic toxins, in the patients with End Stage Renal Disease (ESRD).
- Trial name
- NCT03010735
- Testing
- probiotics
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- China Agricultural University
Microbiota, Nutrition, Healthy
Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined.
- Trial name
- SUSUGUT (NCT05231317)
- Testing
- Plant-based diet, Western diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Term and Preterm Neonates (24-41 Weeks Gestational Age), Hematopoietic Stem Cell Transplant Recipient Children
Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients
The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem…
- Trial name
- NEOMAIT (NCT02403089)
- Testing
- Tubes fund recovery blood count, the rest of the blood test and stool sample
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Arterial Disease
Gut Microbiota in Patients With Peripheral Arterial Disease and Chronic Limb-threatening Ischemia
Microbiota has been associated with risk factors for cardiovascular diseases (hypertension, obesity, dyslipidemia, diabetes mellitus, heart failure).
- Trial name
- NCT05757297
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Type 1 Diabetes
Do People With Complications of Type 1 Diabetes Mellitus Have a Different Microbiome (MARVEL)
This study looks at whether people with type 1 diabetes have different gut bacteria. We also want to see if this is linked to keeping insulin production up and preventing complications like heart disease and nerve damage.
- Trial name
- MARVEL (NCT06560060)
- Testing
- No intervention
- Volunteers
- 5,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colitis, Ulcerative, Sleep Quality
Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis
Ulcerative colitis(UC) is one of the two main forms of inflammatory bowel disease(IBD), which seriously affects the quality of life of patients.
- Conditions
- Colitis, Ulcerative, Sleep Quality, Gastrointestinal Microbiome, Autonomic Nervous System Imbalance
- Trial name
- NCT06359808
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Cirrhosis, Hepatocellular Carcinoma
Microbiota Study in Liver Transplanted Patients
Many studies describe the relationship between microbiota alteration and the occurrence of metabolic, alcoholic or inflammatory liver diseases.
- Conditions
- Cirrhosis, Hepatocellular Carcinoma, Liver Transplant, Microbiota
- Trial name
- BIM-LT (NCT03507140)
- Testing
- Multiple sampling
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Grenoble
Ulcerative Colitis, Crohn Disease
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiotics, mainly from the Lactobacillus and Bifidobacterium genera, originate from fermented foods or the human…
- Trial name
- ANEMONE (NCT07724990)
- Testing
- For a bipsies, rectal administration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
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