Clinical trials: Gastrointestinal Microbiota
Crohn Disease
Fecal Microbiota Transplantation in Crohn's Disease as Relay After Anti-TNF Withdrawal
Crohn's disease (CD) is a chronic inflammatory bowel disease. CD pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota in predisposed hosts.
- Trial name
- MIRACLE (NCT04997733)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis
The Effect of Fecal Microbiota Transplantation in Ulcerative Colitis
7 patients with active Ulcerative Colitis are treated with 25 multi-donor FMT Capsules daily for 50 days.
- Trial name
- NCT03711006
- Testing
- Fecal Microbiota Transplantation Capsules
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Alice Højer Christensen
Autism Spectrum Disorder
WMT for Autism Spectrum Disorder (ASD)
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. A significant comorbidity exists between ADHD and ASD: 30%-50% of individuals with ASD exhibit ADHD symptoms, and two-thirds with ADHD show ASD…
- Trial name
- NCT06030752
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Helicobacter Pylori Infection
Comparing the Efficacy of Reverse Hybrid Therapy and Bismuth Quadruple Therapy
Reverse hybrid therapy achieves a higher eradication rate than bismuth quadruple therapy remained unanswered.
- Trial name
- NCT02547038
- Testing
- pantoprazole+bismuth+tetra+metro, (panto+amox+clar+metr)+(panto+amox)
- Where
- Taiwan
- Volunteers
- 352 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Allergic Rhinitis
Traditional Chinese Medicine for the Treatment of Perennial Allergic Rhinitis on Gut Microbiota and Immune-modulation
40 allergic rhinitis patients in the acute phase will be enrolled in the study. All the allergic patients should be confirmed those who are over 20 years old and hypersensitive to house dust mite allergens confirmed by MAST test…
- Trial name
- NCT04388358
- Testing
- Shin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang by the weight of 9g+3g+3g/day
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Chang Gung Memorial Hospital
Prostate Cancer
Evaluation of Gut Microbiome in Patients With Prostate Cancer
The research will focus on the possible connection between prostate cancer, and various species of bacteria in the large intestine.
- Trial name
- NCT03709485
- Testing
- rectal swab for microbial culture.
- Volunteers
- 150 people
- Sponsor
- Ziv Hospital
Obesity
What is the Impact of Probiotics on Weight Loss Maintenance in Individuals With Obesity?
Weight loss maintenance is the biggest challenge in obesity management, with the majority of weight-reduced individuals experiencing weight regain.
- Trial name
- NCT03287726
- Testing
- probiotics
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- Norwegian University of Science and Technology
Obesity
Does Weight Loss Surgery and Probiotic Supplementation Lead to a "Lean" Gut Microbiota?
The purpose of the weight-loss study is to characterize the effect of LGG supplementation on the relative abundance of phyla in the gut microbiota of patients undergoing gastric bypass and sleeve gastrectomy surgery, and to…
- Trial name
- NCT01870544
- Testing
- Lactobacillus Rhamnosus GG
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Tufts Medical Center
ALS, Amyotrophic Lateral Sclerosis
A Study to Explore the Role of Gut Flora in ALS
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding ALS
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Motor Neuron Disease
- Trial name
- NCT04150809
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Healthy Subjects
The Effects of Fermented Brown Seaweed Intake on Glucose Metabolism and Gut Health
The aim of this randomised, controlled, cross-over study is to investigate whether the intake of fermented brown seaweed can lower postprandial blood glucose levels and influence the composition of the gut microbiota in 25…
- Trial name
- SEAPRO01 (NCT06418763)
- Testing
- Baobab spread mixed with fermented brown seaweed, Baobab spread
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aventure AB
A03 - Digestive System, 03 - Bacteria
Stool Collection for Model
Purpose of this study is to collect stool samples from healthy volunteers
- Trial name
- StoColM (NCT06988514)
- Testing
- Standardized stool collection from healthy volunteers
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Obesity, Intestinal Bacteria Flora Disturbance
Study on Dietary Nutrition Intervention Techniques for Children Obesity
With the rapid development of society and economy, children's simple obesity is the rising in the world and has become a chronic disease which is one of the biggest public health challenges in the world.
- Conditions
- Obesity, Intestinal Bacteria Flora Disturbance, Body Weight
- Trial name
- NCT02539836
- Testing
- Dietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Gut Microbiome, Gastrointestinal Microbiome
A Study to Explore the Role of Gut Flora in COVID-19 Infection
This study seeks to determine whether the virus which causes COVID-19, SARS-CoV-2, is shed in the stools of patients who are infected.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, COVID, COVID-19
- Trial name
- NCT04359836
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Microbiome, Vaccine
Gut Microbiota, the Potential Key to Modulating Humoral Immunogenicity of New Platform COVID-19 Vaccines
Vaccination is the best way to mitigate the coronavirus disease 2019 (COVID-19) pandemic, but the vaccine immunogenicity may be quite variable from person to person.
- Conditions
- Microbiome, Vaccine, Covid-19, SARS-CoV-2
- Trial name
- NCT05150834
- Testing
- This is observational study
- Where
- South Korea
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Acquired Immunodeficiency Syndrome, Healthy Volunteers
Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea
This study is intended to evaluate: 1. Any changes in the gut microbiome from baseline compared to end of study in both healthy (HIV-negative) subjects and HIV+ patients with or without chronic diarrhea, following one month of…
- Conditions
- Acquired Immunodeficiency Syndrome, Healthy Volunteers, HIV/AIDS, HIV Diarrhea
- Trial name
- NCT04192487
- Testing
- Crofelemer delayed-release tablets 125mg
- Where
- 3 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Napo Pharmaceuticals, Inc.
Gut -Microbiota, Inflammatory Markers
Walnuts as an Infant Solid Food for Health
The objective is to investigate the effect of walnuts on gut microbiota, inflammatory markers, atopic dermatitis status, and indices of allergy outcomes in breastfed infants during early complementary feeding.
- Conditions
- Gut -Microbiota, Inflammatory Markers, Infant Development
- Trial name
- WISH (NCT07081698)
- Testing
- Infant walnut intake
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Colorado State University
Hepatic Encephalopathy
Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study (POEME)
TIPS is a standard for the treatment of portal hypertension related complications. However, it remains at risk of HE after TIPS (around 40% the first year). Dysbiosis plays a key role in pathophysiology of HE.
- Trial name
- POEME (NCT05206487)
- Testing
- Polydextrose
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Trimethylamine-N-oxide, Gut Microbiota
Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) - WineFlora Study
Recent evidence indicates that Trimethylamine-N-oxide (TMAO) is a pro-atherosclerotic, phosphatidylcholine-dependent metabolite of diet and intestinal flora.
- Conditions
- Trimethylamine-N-oxide, Gut Microbiota, Effects of Red Wine, Atherosclerosis
- Trial name
- NCT03232099
- Testing
- Red Wine consumption, Period without alcohol consumption
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo General Hospital
Constipation, Cancer
A Study of Herbal Supplements in Cancer Survivors With Constipation
The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but…
- Conditions
- Constipation, Cancer, Functional Constipation
- Trial name
- NCT07091084
- Testing
- MZRW
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cognitive Assessment, Psychological Function
Snacks and Brain Health
This project will investigate whether daily snack consumption can improve memory, mood, and overall brain function in people with cognitive impairment.
- Conditions
- Cognitive Assessment, Psychological Function, GI Health
- Trial name
- NCT07348406
- Testing
- Pecan snack, Pretzel snack
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Texas Tech University Health Sciences Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.