Clinical trials: Gastrointestinal Microbiota
Urinary Bladder Neoplasms, Uterine Cervical Neoplasms
Effect of Pelvic Radiotherapy on the Intestinal Microbiome and Metabolome
Eight in ten patients will develop bowel problems during radiotherapy, eg diarrhoea, pain and incontinence, half will develop difficult long-term bowel problems.
- Conditions
- Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Endometrial Neoplasms
- Trial name
- EPRIMM (NCT04995809)
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- The Christie NHS Foundation Trust
Colorectal Cancer
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer
The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC).
- Trial name
- NCT06379412
- Testing
- observational study, no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Kidney Diseases, Cachexia
CKD Cachexia and Gut Microbiome
Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main…
- Trial name
- DYNAMICA (NCT06986265)
- Testing
- Collection of clinical data and biological sampling
- Where
- 2 sites in Belgium
- Volunteers
- 157 people
- Sponsor
- Université Catholique de Louvain
Obesity, Non-alcoholic Fatty Liver Disease (NAFLD)
Dietary Intervention and Intestinal Microbiota in Non-alcoholic Fatty Liver
In patients with NAFLD/NASH, changes in liver lipid composition and function tests following a short dietary intervention are associated with changes in gut microbiota
- Trial name
- NCT01477307
- Testing
- Hypocaloric diet
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
HIV Infections
Gut Microbiota, PGx and INSTIs Response
This is an interventional phase IV trial enrolling HIV-infected patients treated by dolutegravir or bictegravir-based combined antiretroviral therapy, and patients with a planned shift to a dolutegravir or bictegravir-based…
- Trial name
- NCT04805944
- Testing
- Dolutegravir, Bictegravir
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diet, Food, and Nutrition, Exercise
The NutriNet-Santé Study
The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between…
- Conditions
- Diet, Food, and Nutrition, Exercise, Diseases Category, Cohort Studies
- Trial name
- NCT03335644
- Where
- France
- Volunteers
- 170,000 people, healthy volunteers welcome
- Sponsor
- University of Paris 13
Pediatric Obesity
MEDKIDS: Nutritional Intervention With Improved Bread and Bakery Products in Children With Overweight and Obesity
The goal of this randomized crossover clinical trial is to evaluate the effect of an intervention with nutritionally improved bread and bakery products on body composition and metabolic health in children aged 6 to 12 years with…
- Trial name
- MEDKIDS (NCT07786675)
- Testing
- Nutritionally improved bread and bakery products, Conventional bread and bakery products
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Inflammatory Bowel Diseases, Clostridium Difficile Infection
ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI
This is a randomized controlled trial to assess the clinical and microbiological impacts of FMT in combination with Bezlotoxumab (bezlo) compared to FMT in combination with placebo in patients with both inflammatory bowel disease…
- Trial name
- ICON-2 (NCT03829475)
- Testing
- Bezlotoxumab, Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Brigham and Women's Hospital
PCOS, Obesity
The Gut Microbiome in Women With Polycystic Ovary Syndrome
Testing two different strategies for weight loss intervention and revealing possible changes in composition of gut microbiota, in order to provide more insight in the effect of dietary changes and weight loss treatments on gut…
- Conditions
- PCOS, Obesity, Metabolic Syndrome
- Trial name
- NCT03642600
- Testing
- dietary advice plus myo-inositol and folic acid, dietary advice plus Liraglutide Pen Injector
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Immune Thrombocytopenia
Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder, accounting for about 1/3 of clinical hemorrhagic diseases.
- Trial name
- NCT03033199
- Testing
- Probiotic Agent, Dexamethasone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Preterm Birth, Low Birth Weight
Description and Comparison of Biological Vulnerability in Small Vulnerable Newborns Versus Healthy Community Controls in Urban Burkina Faso
The aim of the DenBalo study is to apply integrated multi-omics methods to examine the biological mechanisms underlying this vulnerability in Small Vulnerable Newborns (SVNs) in LMICs, with the ultimate goal of identifying…
- Conditions
- Preterm Birth, Low Birth Weight, Small for Gestational Age at Delivery
- Trial name
- DenBalo (NCT05730569)
- Where
- Burkina Faso
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Ghent
Vitamin A Deficiency in Children
The Effects of Biscuits Containing Red Palm Oil on School Children With Vitamin A Deficiency in West and East Malaysia
Based on recent nutrition survey (SEANUTS Malaysia) on a total of 3542 Malaysian Children aged between 6 months to 12 years old, 4.4% of the children had vitamin A deficiency.
- Trial name
- NCT03256123
- Testing
- red palm shortening group, palm shortening group
- Where
- Malaysia
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Psoriasis Vulgaris, Rheumatoid Arthritis
Liver Fibrosis and Gut Microbiota in Patients With Psoriasis Vulgaris and Rheumatoid Arthritis on Methotrexate
While methotrexate (MTX) remains a treatment of choice for patients with rheumatoid arthritis (RA), psoriasis (PsO) and psoriatic arthritis (PsA), long-term MTX use has been shown to be associated with liver fibrosis and…
- Conditions
- Psoriasis Vulgaris, Rheumatoid Arthritis, Fibrosis, Liver
- Trial name
- NCT04493762
- Volunteers
- 600 people
- Sponsor
- The University of Hong Kong
Crohn's Diseases
Washed Microbiota Transplantation Improves Nutritional Status of Patients With Crohn's Disease
Patients with Crohns' disease (CD) are always complicated with malnutrition. Exclusive enteral nutrition (EEN) is an effective treatment to improve nutritional status and induce remission in patients with CD however a reduction…
- Trial name
- NCT02897661
- Testing
- WMT, EEN
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Second Hospital of Nanjing Medical University
IBD - Inflammatory Bowel Disease
Investigating Chinese Herbal Medicine for Modulating Gut Microbiota in Treating Inflammatory Bowel Disease: Molecular Mechanisms and Clinical Study
The goal of this exploratory, single-arm intervention study is to evaluate whether Banxia Xiexin Decoction (BXD) can prevent colitis by modulating gut microbiota composition and regulating immune responses, including IgA…
- Trial name
- NCT07035613
- Testing
- BXD treatment
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Influenza Vaccine Response
Effect of Oral Supplements for Influenza Vaccine Response
The aim of this clinical trial is to explore the efficacy of fatty acid and bile acid based supplements on enhancing influenza vaccine immune response in adults aged 60-70 years. The objectives of this study are: 1.
- Trial name
- EOSIIVE-RCT (NCT06827873)
- Testing
- ARA (Arachidonic Acid) Supplementation, TUDCA (Tauroursodeoxycholic Acid) Supplementation, Shanghai Biological Quadrivalent Influenza Virus Inactivated Vaccine
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy (CT), often requiring dose reductions or treatment interruptions, which can compromise efficacy of the planned CT…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQTmicrob (NCT06799351)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Digestion, Gut Microbiota
Feeding Tolerance and Gut Maturation of Infants Consuming a Formula Rich in Glycoprotein
This is a non-randomized, single-arm, open-label, prospective interventional study using a commercially available starter infant formula in healthy term formula-fed infants with a parallel group of healthy term breast-fed infants…
- Trial name
- NCT04880083
- Testing
- Commercially Available Starter Infant Formula
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cholangiopancreatography, Endoscopic Retrograde, Common Bile Duct Calculi
Study of Microbiota in Bile From Patients With Common Bile Duct Stone During ERCP
In this study, investigators will investigate the microbiota of bile in common bile duct stone participants. Three key questions are of concern.
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Common Bile Duct Calculi, Microbial Colonization
- Trial name
- NCT03490383
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Overweight Adults
Effects of a Sugar-Based Synbiotic Product on Cardiometabolic and Intestinal Health (SUGAR-SYN BC3O)
This randomized, double-blind, controlled, crossover study investigates the effects of a sugar-based synbiotic product containing inulin and Bacillus coagulans BC30™ spores in healthy overweight individuals.
- Trial name
- SUGAR-SYN BC3O (NCT07806383)
- Testing
- Sugar-Based Synbiotic Product, Inulin-Containing Sugar Product
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
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