Clinical trials: Gastrointestinal Neoplasm
Colorectal Cancer
Veteran Primers for CRC Screening
This is a prospective, randomized controlled trial that will evaluate the effectiveness of primer postcards sent two weeks prior to the mailing of a FIT kit in improving adherence to annual CRC screening.
- Trial name
- NCT04923646
- Testing
- Primer
- Where
- United States
- Volunteers
- 2,404 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Esophageal Cancer
Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer
This study will evaluate if proton beam therapy as part of chemoradiation results in a decrease in diffusion lung capacity of carbon monoxide (DLCO) compared to photon radiation therapy for esophageal carcinoma.
- Trial name
- ES01 (NCT03234842)
- Testing
- Proton Beam Therapy, Photon Radiation Therapy, Chemotherapy
- Where
- United States
- Sponsor
- University of Florida
Hepatocellular Carcinoma
The Combination Effect of Statin Plus Metformin on Relapse-free
The study demonstrated that either statin or metformin served as notable use in reducing the incidence of many cancers.
- Trial name
- NCT02819869
- Testing
- Statin and Metformin use
- Where
- Taiwan
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Esophageal Cancer
Prehabilitation in Esophageal Cancer Care
Prehabilitation utilizes the preoperative period to prevent or attenuate the treatment-related functional decline and its consequences.
- Trial name
- NCT04581005
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Cancer
A Study of Avastin (Bevacizumab) and Xeloda (Capecitabine) as Maintenance Treatment in Patients With Metastatic Colorectal Cancer
This 2 arm study assessed the efficacy and safety of maintenance treatment with Avastin (bevacizumab) + Xeloda (capecitabine), after initial treatment with Xeloda + oxaliplatin + Avastin, in patients with metastatic colorectal…
- Trial name
- NCT00623805
- Testing
- Bevacizumab, Capecitabine, Oxaliplatin
- Where
- 10 sites in Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Hoffmann-La Roche
Liver Decompensation, Hepatocellular Carcinoma
The Second Multicenter Hemophilia Cohort Study
The Second Multicenter Hemophilia Cohort Study (MHCS-II) will evaluate and prospectively follow approximately 4500 persons with hemophilia who were exposed to hepatitis C virus (HCV).
- Conditions
- Liver Decompensation, Hepatocellular Carcinoma, Non-Hodgkin Lymphoma
- Trial name
- NCT00341705
- Where
- 48 sites in United States, Brazil and 6 more
- Volunteers
- 2,565 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer (CRC), Gastric Cancer (GC)
A Prospective Real-World Observational Study of Intratumoral Oncolytic Virus Injection Combined With Immune Checkpoint Inhibitors for Metastatic Tumors (Colorectal Cancer, Gastric Cancer, and Hepatocellular Carcinoma)
The goal of this single-arm, open-label, prospective clinical trial is to evaluate the safety, feasibility, and preliminary antitumor activity of intratumoral oncolytic virus (H101, recombinant human type 5 adenovirus) combined…
- Conditions
- Colorectal Cancer (CRC), Gastric Cancer (GC), Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07850882
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jie Yuan，MD
Esophageal Neoplasms, Esophagus Stenosis
Oral Prednisolone to Prevent Esophageal Stricture After RFA for Long-segment Esophageal Neoplasia
Endoscopic radiofrequency ablation (RFA) has shown good efficacy and safety in eradicating flat-type early esophageal squamous cell neoplasia (ESCN).
- Trial name
- NCT05768282
- Testing
- Oral prednisolone (30mg/day) for 28 days
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- E-DA Hospital
Metastatic Pancreatic Cancer
Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma
This is a Phase I open labelled study to treat patients with metastatic pancreatic cancer with combination therapy using standard of care first line therapy with gemcitabine and nab-paclitaxel given days 1, 8, and 15 every 28…
- Trial name
- ProglumidePanc (NCT06017323)
- Testing
- Gemcitabine, Nab paclitaxel, Proglumide Dose level 1
- Where
- United States
- Sponsor
- Georgetown University
GI Cancer
Macroscopic on Cite Evaluation of EUS-FNA Specimen With 22 G Needle
In order for the diagnosis of digestive system tumors and their appropriate treatment afterward, the type of these tumors should be determined by the pathologist.
- Trial name
- NCT04774679
- Testing
- Endosonographic fine needle aspiration biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
NSCLC, SCLC
Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study
This study is an exploratory study, and all the drugs involved are listed drugs. The dosage of mirabetron is selected according to the basis of previous research.
- Conditions
- NSCLC, SCLC, Colorectal Cancer, Pancreas Cancer
- Trial name
- NCT06534762
- Testing
- Mirabegron
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhejiang Provincial People's Hospital
Tumor, Colorectal, Organoids
Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)
COSENSE-1 is an unblinded, phase II, single-armed, single center feasibility study for using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens, for male and female…
- Conditions
- Tumor, Colorectal, Organoids, Tumoroid, Metastatic Colorectal Cancer
- Trial name
- COSENSE-1 (NCT06907342)
- Testing
- FOLFOX or FOLFIRI
- Where
- Norway
- Volunteers
- 148 people
- Sponsor
- St. Olavs Hospital
Solid Tumors
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
The purpose of this study is to evaluate the efficacy and safety of standard chemotherapy with or without INCB161734 in participants with metastatic pancreatic ductal adenocarcinoma (PDAC).
- Trial name
- DAWN-303 (NCT07522073)
- Testing
- INCB161734, Investigator's choice of chemotherapy
- Where
- 230 sites in United States, Australia and 20 more
- Volunteers
- 588 people
- Sponsor
- Incyte Corporation
Breast Cancer, Prostate Cancer
Integration of Cancer Health Activities Into African American Churches
The proposed project will compare two ways to apply a known-effective cancer educational strategy through African American churches: 1) a standard method vs.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT03178383
- Testing
- Project HEAL, Project HEAL 2.0
- Where
- United States
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Esophageal Cancer, Metastatic Cancer
European iNvestigation of SUrveillance After Resection for Esophageal Cancer
The ENSURE study will comprise two phases. Phase 1: European multicenter survey of surveillance protocols after esophageal cancer surgery ENSURE questionnaire will be circulated to representatives from participating European…
- Conditions
- Esophageal Cancer, Metastatic Cancer, Recurrent Esophageal Cancer, Chemoradiation
- Trial name
- ENSURE (NCT03461341)
- Testing
- High intensity postoperative oncologic surveillance
- Where
- 3 sites in Ireland, Sweden and 1 more
- Volunteers
- 3,000 people
- Sponsor
- St. James's Hospital, Ireland
Rectal Cancer
Transanal Versus Laparoscopic Total Mesorectal Excision: a Cohort
The purpose of this study was to compare the long-term oncology outcomes and specimen quality of taTME and laTME in the treatment of middle and low rectal cancer by a large sample cohort.
- Trial name
- NCT05682794
- Testing
- transanal total mesorectal excision
- Volunteers
- 2,502 people
- Sponsor
- Sun Yat-sen University
Neuroendocrine Tumors, Autoimmune Pancreatitis
A Real-world Comparison of FNB and FNA in IHC-required Lesions.
Endoscopic ultrasound (EUS)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis.
- Conditions
- Neuroendocrine Tumors, Autoimmune Pancreatitis, Gastrointestinal Stromal Tumors
- Trial name
- NCT05565066
- Testing
- FNB group, FNA group
- Where
- China
- Volunteers
- 439 people
- Sponsor
- Huazhong University of Science and Technology
Cirrhosis of Liver
Gadoxetic Acid-MRI Versus Ultrasonography for the Surveillance of Hepatocellular Carcinoma in High-risk Patients
Current practice guidelines recommend surveillance for hepatocellular carcinoma (HCC) in liver cirrhosis patients with ultrasonography (USG) every 6 months.
- Trial name
- PRIUS (NCT01446666)
- Where
- South Korea
- Volunteers
- 423 people
- Sponsor
- Asan Medical Center
Biliary Tract Cancer
A Study of Selective HDAC6 Inhibition With KA2507 in Advanced Biliary Tract Cancer
To evaluate the preliminary efficacy of KA2507 (an orally active potent and selective HDAC6 inhibitor) in patients with advanced biliary tract cancer (BTC) previously treated with standard of care chemotherapy.
- Trial name
- NCT04186156
- Testing
- KA2507
- Where
- United Kingdom
- Sponsor
- Karus Therapeutics Limited
Colorectal Cancer
PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer
PD-1(programmed death protein 1)antibody has been to approved in patients with MSI-H/dMMR advanced cancer and has achieved significant efficacy.
- Trial name
- PCOX (NCT03638297)
- Testing
- PD-1 antibody + cox inhibitor
- Where
- 2 sites in China
- Volunteers
- 29 people
- Sponsor
- Sun Yat-sen University
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