Clinical trials: Gastrointestinal Neoplasm Malignant
Advanced Gastrointestinal Cancer
89Zr-AMG211 PET Imaging Study
AMG 211 is a bispecific single-chain antibody construct of the bispecific T-cell engager (BiTE®) class that targets human carcinoembryonic antigen (CEA, CD66e) on (tumor) cells and cluster of differentiation 3 (CD3) positive…
- Trial name
- NCT02760199
- Testing
- 89Zr-AMG211, 89-ZrAMG211 PET
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- University Medical Center Groningen
Pancreatic Neoplasms
Study of PEP02 as a Second Line Therapy for Metastatic Pancreatic Cancer
The purpose of this study is to see the effect of PEP02 in the treatment of metastatic pancreatic cancer.
- Trial name
- NCT00813163
- Testing
- PEP02
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 41 people
- Sponsor
- PharmaEngine
Colorectal Cancer, Peritoneal (Metastatic) Cancer
Comparing 18F-FAPI PET-Guided Abdominal Radiotherapy Combined With Second-Line Standard Therapy and Cadonilimab Versus Second-Line Standard Therapy in Colorectal Cancer With Peritoneal Metastasis
Main objective: 1. To compare the objective response rate (ORR) of 18F-FAPI PET-guided abdominal region radiotherapy combined with second-line standard treatment versus cadonilimab and second-line standard treatment in the…
- Conditions
- Colorectal Cancer, Peritoneal (Metastatic) Cancer, FAPI PET
- Trial name
- NCT07079462
- Testing
- Radiotherapy followed by immunotherapy and chemotherapy, Chemotherapy (control)
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Cancer, Breast Cancer
Genomic Investigation of Unusual Responders
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic…
- Conditions
- Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- GENIUS (NCT03740503)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer, Surgery
Physical Activity in Relation to Surgical Procedures
This study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.
- Trial name
- NCT02299596
- Testing
- Physical activity
- Where
- 2 sites in Sweden
- Volunteers
- 761 people
- Sponsor
- Sahlgrenska University Hospital
Colorectal Cancer
A Study of FOLFIRI Plus OMP-21M18 as 1st or 2nd-line Treatment in Subjects With Metastatic Colorectal Cancer
The purpose of this study is to test the safety and determine the optimal dose of a new drug, OMP-21M18, when given in combination with FOLFIRI, a standard drug treatment for advanced colorectal cancer.
- Trial name
- NCT01189942
- Testing
- OMP-21M18
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 18 people
- Sponsor
- OncoMed Pharmaceuticals, Inc.
Liver Neoplasms, Local Neoplasm Recurrence
PET-MRI After Radiofrequency Ablation (RFA) or Microwave Ablation (MWA)
The primary objective of this study is to evaluate the ability of PET-MRI and to detect a local site recurrence during the first year of follow-up after RFA or MWA of colorectal liver metastases (CRLM) as compared with contrast…
- Trial name
- NCT01895673
- Testing
- Gadolinium
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- dr. M.P. van den Tol MD PhD
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal, Gynecological, Breast, or Lung Cancer
This phase II trial tests how well fucoidan works in preventing chemotherapy-related fatigue compared to a placebo in patients with gastrointestinal (GI), gynecological (GYN), breast, or lung cancer.
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Breast Carcinoma, Lung Carcinoma
- Trial name
- NCT06855524
- Testing
- Biospecimen Collection, Oligo-fucoidan, Questionnaire Administration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Colorectal Carcinoma, Endometrial Carcinoma
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory).
- Conditions
- Colorectal Carcinoma, Endometrial Carcinoma, Melanoma, Neuroblastoma
- Trial name
- NCT04851119
- Testing
- Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint
- Where
- 21 sites in United States
- Volunteers
- 147 people
- Sponsor
- Children's Oncology Group
Cancer, Breast, Cancer, Lung
Patient Education Videos to Improve Patients' Experience During Radiotherapy Treatment: a National Project
Patients often base their information on the experiences of other patients or on information they find on the internet. This information is in many cases incorrect, outdated or not applying to the patient's situation.
- Conditions
- Cancer, Breast, Cancer, Lung, Cancer Prostate, Cancer Head Neck
- Trial name
- NCT06152419
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Ghent
Gastrointestinal Cancer
Use of DRS Probe and Tracking for In-vivo Application
A spectroscopic probe is a sensor designed to illuminate and gather light directly from the tissue while touching it. The probe contains optical fibres, some which illuminate the surface of the tissue with harmless visible…
- Trial name
- NCT05830292
- Testing
- Diffuse reflectance spectroscopy (DRS) probe
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Advanced Gastrointestinal Cancers
Feasibility of a Molecular Characterisation Approach to Treatment
This study will assess the feasibility of sequencing locally advanced/metastatic gastrointestinal cancers in real-time to enable future treatment stratification by molecular characteristics.
- Trial name
- FOrMAT (NCT02112357)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Esophageal Cancer TNM Staging, Magnetic Resonance Imaging
The Application of 3T MRI in Esophageal Cancer
It is very significant that assessing TN staging in esophageal cancer patients before surgery, furthermore, determining the optimize surgical strategy, predict the the efficacy of radiotherapy for patients who were not chosen to…
- Conditions
- Esophageal Cancer TNM Staging, Magnetic Resonance Imaging, Prognosis
- Trial name
- NCT03635619
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Breast Cancer, Head and Neck Cancer
A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6
This study evaluated the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. The study was conducted in patients with several types of refractory cancers including those at the surface of the…
- Conditions
- Breast Cancer, Head and Neck Cancer, Squamous Cell Carcinoma, Lymphoma
- Trial name
- IT-01 (NCT03058289)
- Testing
- INT230-6, anti-PD-1 antibody, anti-CTLA-4 antibody
- Where
- 8 sites in United States, Canada
- Volunteers
- 111 people
- Sponsor
- Intensity Therapeutics, Inc.
Liver Metastases, Colorectal Neoplasms
Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurrent Liver Metastases
The purpose of the study is to assess the overall survival and progression free survival of patients treated with Litx™ + chemotherapy versus chemotherapy alone in the treatment of Colorectal Cancer with recurrent liver…
- Conditions
- Liver Metastases, Colorectal Neoplasms, Neoplasm Metastasis, Neoplasm Recurrence, Local
- Trial name
- NCT00440310
- Testing
- Talaporfin sodium, Percutaneous placement of device in liver metastases, Interstitial light emitting diodes
- Where
- 57 sites in Austria, Bosnia and Herzegovina and 11 more
- Volunteers
- 483 people
- Sponsor
- Light Sciences Oncology
Colorectal Cancer, Metastasis
Hepatic Artery Infusion With Oxaliplatin
Hepatic artery infusion (HAI) with oxaliplatin (OX), systemic 5 fluorouracil (5FU), and leucovorin (HAI/OX/FU) will be implemented using an interventional radiology technique to obviate the need for initial major surgery…
- Conditions
- Colorectal Cancer, Metastasis, Liver Cancer
- Trial name
- NCT00244348
- Testing
- Oxaliplatin (via HAI), 5 Fluorouracil (systemic)
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Esophageal Cancer, Esophageal Neoplasms
Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer
This study aims to develop and evaluate a model for systematic and evidence-based cancer rehabilitation for people with esophageal and gastric cancer to provide conditions for a better quality of life and fewer cancer-related…
- Conditions
- Esophageal Cancer, Esophageal Neoplasms, Gastric Cancer, Stomach Neoplasm
- Trial name
- NCT05698992
- Testing
- evidence-based individualized rehabilitation
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Bile Duct Obstruction, Klatskin's Tumor
Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture
The overall median survival of nonresectable malignant hilar obstruction in most series has been less than 6 months. Most patients with malignant hilar obstruction present with advanced disease, making palliative endoscopic…
- Trial name
- NCT01125865
- Testing
- SEMS insertion, DLS insertion
- Where
- 4 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Soon Chun Hyang University
Pancreatic Cancer, Breast Cancer
The Clinical Application Value of SPECT Imaging Targeting LRRC15 in Malignant Tumors
Here's a polished version of the text: "This project involves patients with high-expression LRRC15 malignant tumors who are either clinically suspected of or diagnosed with pancreatic cancer, breast cancer, lung cancer, ovarian…
- Conditions
- Pancreatic Cancer, Breast Cancer, Lung Cancer, Sarcoma
- Trial name
- NCT07651020
- Testing
- Specific SPECT imaging agents targeting LRRC15
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colorectal Cancer, Pancreatic Cancer
Evaluation of Safety and Activity of an Anti-PDL1 Antibody (DURVALUMAB) Combined With CSF-1R TKI (PEXIDARTINIB) in Patients With Metastatic/Advanced Pancreatic or Colorectal Cancers
Colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) are the most common gastrointestinal cancers in Western countries and are both associated with significant morbidity and mortality.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Metastatic Cancer, Advanced Cancer
- Trial name
- MEDIPLEX (NCT02777710)
- Testing
- Pexidartinib, Durvalumab
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Centre Leon Berard
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