Clinical trials: Gastrointestinal Peptides and Hormones
Bariatric Surgery (Gastric Bypass), Overweight
The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in…
- Trial name
- NCT02372526
- Testing
- Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Digestive Physiology, Gastrointestinal Motility
Effects of Exendin(9-39) on Gastroduodenal Motility
The purpose of this study in humans is to define the effects of the endogenous hormone GLP-1 on gastroduodenal motility and on endocrine pancreatic secretion by using the specific GLP-1 receptor antagonist exendin(9-39).
- Conditions
- Digestive Physiology, Gastrointestinal Motility, Gastrointestinal Hormones, Glucagon-like Peptide 1
- Trial name
- NCT00468091
- Testing
- exendin(9-39)amide, atropine
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Physiology - Regulation of Appetite and Food Intake
Neurotensin - an Important Regulator of Appetite in Humans?
Neurotensin (NT) is a gut peptide released postprandially from the small intestine. It is known to exert a range of enterogastrone effects and in animal models it reduces food intake when administered by parenteral routes.
- Trial name
- NIRAH (NCT03522792)
- Testing
- Neurotensin, Saline, Ad libitum meal
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gastrointestinal Motility Disorder, Disturbance of Salivary Secretion
Nitric Oxide Control of Migrating Motor Complex: L-NMMA Effects in Relation to Receptor Blockades
The aim is to elucidate how NO works in conjunction with other neurotransmitters to regulate the migrating motility complex (MMC).
- Trial name
- LNMMA (NCT02245165)
- Testing
- L-Nitro-Monomethyl-Arginine (LNMMA) 10 mg/kg IV, saline
- Where
- Sweden
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity
Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release
The worldwide increase in the prevalence of obesity is a cause of great concern. Pharmacological treatment options are being explored at the moment with a major focus on the hormones produced by the gastrointestinal tract which…
- Trial name
- NCT04873011
- Testing
- Quinine Hydrochloride
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Neoplasms, Stomach Neoplasms
Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer
Surgery is the cornerstone of treatment for patients with oesophageal or gastric cancer, but while surgical removal of the tumour (oesophagectomy or gastrectomy) may offer the best chance of cure, these are major operations…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385630
- Testing
- Standardized 400kcal semi-liquid meal
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- St. James's Hospital, Ireland
Esophageal Neoplasms, Stomach Neoplasms
The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery
Improvements to treatment strategies for patients with cancers of the upper gastrointestinal tract have produced a large population of people who remain free from cancer recurrence in the long term following treatment.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02381249
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Diabetes Mellitus, Type 2
The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones
The aim of this study is to investigate the effects of combined administration of mosapride as modulator of gastrointestinal motility and DPP-4 inhibitor on secretion of gut hormone such as glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT02180334
- Testing
- Mosapride citrate, Linagliptin, Acetaminophen (paracetamol)
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Anti Obesity Agent
Inhibition of Food Intake in Response to Oral GLP-1 and Peptide YY3-36
Interaction of GLP-1 and PYY3-36 in the inhibition of food intake in healthy subjects
- Trial name
- NCT00822705
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Short Bowel Syndrome
Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome
The aim of the study is to investigate the effect of the enteric hormone Glucagon-like Peptide (GLP-2) on patients with short bowel syndrome
- Trial name
- NCT00673751
- Testing
- GLP-2
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Cervical Cancer, Breast Cancer
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or…
- Conditions
- Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
- Trial name
- NCT05283330
- Testing
- ²¹²Pb-DOTAM-GRPR1
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Orano Med Theranostics, SAS
Postural Tachycardia Syndrome
Gastrointestinal Symptoms in Postural Orthostatic Tachycardia Syndrome
Patients with POTS experience significant gastrointestinal symptoms. Current evidence suggesting that abnormal post-ganglionic sympathetic function could play a role in the pathophysiology of these GI abnormalities.
- Trial name
- POTS-GUT (NCT03263819)
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Satiety, Glycemic Index
Incorporating Avocados in Meals
The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release.
- Conditions
- Satiety, Glycemic Index, Insulin, Gastrointestinal Peptides and Hormones
- Trial name
- NCT01271829
- Testing
- Avocado supplement, Avocado included
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Irritable Bowel Syndrome, Obesity
Moderate Continuous Versus High Interval Intensity Training on Gut Dysbiosis and GLP1 Hormone in IBS
investigating the response of gut bacteria via measuring short chain fatty acids and Glucagon like peptide hormone to two different modes of exercises in pre-diabetic, obese patients with irritable bowel syndrome.
- Conditions
- Irritable Bowel Syndrome, Obesity, Dysbiosis
- Trial name
- NCT06408610
- Testing
- moderate intensity continuous training
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University