Clinical trials: Gastrointestinal Reflux
Non-erosive Reflux Disease
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
- Trial name
- NCT03967886
- Testing
- YYD601 20mg, Nexium 20mg
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Gastroesophageal Reflux Disease (GERD)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)
This study includes patients with sleep disturbances associated with gastroesophageal reflux disease (GERD) and has 3 treatment arms.
- Trial name
- NCT00628342
- Testing
- Esomeprazole
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GERD) Patients in Chinese Population
A questionnaire composed of items addressing psychological, emotional and social aspects of GERD is developed for Chinese population.
- Trial name
- NCT00165022
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Barrett Esophagus, Dysplasia
Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease
This pilot clinical trial studies how well a swallowable sponge cell sampling device and next generation sequencing work in detecting esophageal cancer in patients with low or high grade dysplasia, Barrett esophagus, or…
- Conditions
- Barrett Esophagus, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02890979
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- OHSU Knight Cancer Institute
Regurgitation, Gastric
Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric Emptying
The primary objective of this trial is to show that an hypoallergenic infant starter formula containing starch and the probiotic L.
- Trial name
- NCT01956682
- Testing
- HA formula + starch + L. reuteri
- Where
- Italy
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Bari
Gastroesophageal Reflux Disease
A Retrospective Analysis of Patients With Gastroesophageal Reflux Disease Based on a Prospective Clinical Dataset
This retrospective, observational cohort study aimed to establish a comprehensive research cohort utilizing a large-scale prospective clinical registry.
- Trial name
- NCT07749989
- Testing
- Clinical Data Collection
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Friendship Hospital
Refractory Gastroesophageal Reflux Disease
Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)
Anti-reflux mucosectomy (ARMS) may be a new therapy for refractory gastroesophageal reflux disease (RGERD). The aim of the present study is to explore the safety and efficacy of ARMS.
- Trial name
- NCT03259191
- Testing
- anti-reflux mucosectomy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruihua Shi
Gastroesophageal Reflux Disease (GERD)
Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope
This study will recruit patients aged 18-80 with refractory gastroesophageal reflux disease (GERD). These patients had a disease course of more than six months, experienced typical symptoms such as acid reflux and heartburn, and…
- Trial name
- ECCL (NCT07176221)
- Testing
- endoscopic cardia constriction ligation
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ying Zhu
Coronary Artery Disease, Aortic Valve Disorder
Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX
The purpose of the study is to demonstrate the long term safety and effectiveness of the Carpentier-Edwards PERIMOUNT Magna Ease Valves in patients undergoing aortic valve replacement with or without concomitant procedures…
- Conditions
- Coronary Artery Disease, Aortic Valve Disorder, Heart Failure, Aortic Valve Stenosis
- Trial name
- NCT01171625
- Testing
- Implantation of CEP Magna Ease Model 3300TFX
- Where
- 13 sites in United States, Austria and 4 more
- Volunteers
- 283 people
- Sponsor
- Edwards Lifesciences
IPF, Reflux
The Role of Laryngopharyngeal Reflux in IPF
The primary objective of this study is to show that the Supraglottic Index (SGI) is an easily-collected index that accurately identifies the presence and severity of laryngopharyngeal reflux (LPF) in idiopathic pulmonary fibrosis…
- Trial name
- NCT03418350
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Jewish Health
Gastro Esophageal Reflux
Assessment of Esophageal Epithelium Integrity With Use of a Novel Mucosal Impedance Device
The objective of this study is to design and use a novel, minimally invasive mucosal impedance (MI) technology to inexpensively and accurately test mucosal health in suspected gastroesophageal reflux disease (GERD) and nonerosive…
- Trial name
- NCT03103789
- Testing
- single catheter mucosal impedance testing, balloon assembly mucosal impedance testing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Carcinoma, Rectal Prolapse
Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic Surgery
Robotic assisted surgery has been performed for more than two decades with good success and safety profile. However, there was only one dominating robotic surgical system available in the past which led to high cost for robotic…
- Conditions
- Colorectal Carcinoma, Rectal Prolapse, Prostate Cancer (Adenocarcinoma), Bladder Cancer
- Trial name
- NCT06926374
- Testing
- Robotic surgery using the Sentire Surgical System
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Gastroesophageal Reflux Disease, Dyspepsia
Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease
Endoscopic Tri-Modal Imaging which combines Narrow-band Imaging(NBI), Autofluorescence Imaging (AFI) and White-light Imaging (WLI) could be used to identify the indistinct changes in the gut caused by reflux disease,either acid…
- Conditions
- Gastroesophageal Reflux Disease, Dyspepsia, Bile Reflux
- Trial name
- NCT02685150
- Testing
- Endoscopic Tri-Modal Imaging, Omeprazole, Analysis of gastric juice
- Where
- China
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Gastroesophageal Reflux Disease
The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms
Gastroesophageal reflux disease is increasing worldwide. The causes of reflux symptoms are not found exactly. especially, the postprandial reflux symptoms are more common than the all day reflux symptoms.
- Trial name
- NCT02154659
- Testing
- 24hr pH monitoring
- Where
- South Korea
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Reflux Esophagitis (RE)
A Clinical Trial of Anaprazole for Treating Reflux Esophagitis.
This Phase III clinical trial is designed to assess the efficacy and safety of Anaprazole 60 mg once daily (QD) administered over a period of up to 8 weeks, compared with Rabeprazole 20 mg QD, in patients with reflux esophagitis.
- Trial name
- NCT07010107
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Barrett Esophagus
A Minimally-Invasive Sponge on a String Device for Screening for Barrett's Esophagus
This study is being done to collect data on the potential use of a sponge on a string device as a non-invasive tool in evaluating patients with Barrett's Esophagus compared to healthy controls.
- Trial name
- NCT02560623
- Testing
- Biopsy, Biospecimen Collection, Endoscopic Procedure
- Where
- 6 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease, Gastro-oesophageal Reflux
Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease.
The purpose of this observational study (this means that no drug is being tested in this study) is to obtain updated and detailed information about the Gastroesophageal Reflux Disease (GERD) specificities in European patients.
- Conditions
- Gastroesophageal Reflux Disease, Gastro-oesophageal Reflux, Gastro-Esophageal Reflux, Esophageal Reflux
- Trial name
- PROFILE (NCT01601379)
- Volunteers
- 7,964 people
- Sponsor
- Janssen-Cilag International NV
Erosive Esophagitis
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
The aim of the study is to compare the safety and efficacy of two doses of Nexium in maintaining healing of erosive esophagitis in patients 1 to 11 years of age.
- Trial name
- EE (NCT05267613)
- Testing
- Nexium 20mg, Nexium 10mg
- Where
- 41 sites in United States, Argentina and 8 more
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease
The EndoStim Stimulation System is an investigational device intended to improve the lower esophageal sphincter (LES) resting tone and restore LES function in individuals suffering with gastroesophageal reflux disease (GERD).
- Trial name
- NCT01578642
- Testing
- EndoStim LES Stimulation System
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- EndoStim Inc.
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