Clinical trials: Gastrointestinal Reflux
Gastroesophageal Reflux Disease (GERD)
A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
The objective of this study is to evaluate the safety and efficacy of IW-3718 administered to patients with GERD who continue to have persistent symptoms, such as heartburn and regurgitation, while receiving once-daily (QD)…
- Trial name
- NCT03561090
- Testing
- IW-3718, Standard-dose PPIs QD
- Where
- 99 sites in United States, Canada
- Volunteers
- 495 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Gastro-oesophageal Reflux Disease
The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease
Introduction: Gastroesophageal reflux disease (GERD) is a common digestive disorder affecting the esophagus and gastro-duodenum, presenting symptoms such as acid reflux and heartburn.
- Trial name
- NCT06664008
- Testing
- PPI (proton pump inhibitor), Probiotic, Zinc
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Barrett Esophagus
Barrett's Esophagus in Patients with GERD
To assess the prevalence and characteristics of BE in patients suffering of chronic GERD symptoms
- Trial name
- NCT06897540
- Testing
- Upper endoscopy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Barrett's Esophagus, Gastroesophageal Reflux Disease
Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease
To Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia…
- Trial name
- NCT01572974
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Midwest Biomedical Research
Reflux Esophagitis
The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD
The purpose of this study is to assess the efficacy and safety of Newrabell® Tab. in patients with refractory reflux esophagitis to the prior standard PPIs regimen.
- Trial name
- NCT01860482
- Testing
- Newrabell® Tablet 10mg
- Where
- 2 sites in South Korea
- Volunteers
- 39 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Incentive Spirometer, Diaphragmatic Breathing
Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease
The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.
- Conditions
- Incentive Spirometer, Diaphragmatic Breathing, Gastroesophageal Reflux Disease (GERD), Breath Exercise
- Trial name
- NCT07179250
- Testing
- Volume-Oriented Incentive Spirometer, Diaphragmatic Breathing Exercise (DBE), Usual Care and Education
- Volunteers
- 51 people
- Sponsor
- Changhua Christian Hospital
Gastroesophageal Reflux
Safety and Efficacy of Rabeprazole in Infants With Gastroesophageal Erosive Reflux Disease (GERD)
The purpose of this study is to assess the effectiveness and safety of rabeprazole sodium, an inhibitor of gastric acid secretion of the protein pump inhibitor (PPI) class, compared with placebo in the treatment of…
- Trial name
- NCT00992589
- Testing
- Rabeprazole sodium 5 mg, Rabeprazole sodium 10 mg
- Where
- 81 sites in United States, Australia and 8 more
- Volunteers
- 344 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Gastroesophageal Reflux Disease, Epidemiology
Epidemiological Studies and Risk Factor Analysis of GERD in Xiamen City
Gastroesophageal Reflux Disease (GERD) is a condition characterized by the reflux of gastric and duodenal contents into the esophagus, primarily manifested by symptoms such as acid regurgitation and heartburn.
- Conditions
- Gastroesophageal Reflux Disease, Epidemiology, Risk Factors
- Trial name
- NCT06585176
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,625 people
- Sponsor
- Zhongshan Hospital (Xiamen), Fudan University
GERD
A Study to Compare PK, PD and Safety of CKD-382 in Healthy Subjects
To compare pharmacokinetics, pharmacodynamics and safety after single/multiple administration of CKD-382 and D026 in healthy subjects
- Trial name
- NCT04703374
- Testing
- CKD-382(formulation I), CKD-382(formulation II), D026
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD)
Racial Disparity in Barrett's Esophagus
The goal of the proposed research is to investigate the molecular mechanisms of racial disparity in Barrett's esophagus (BE), the premalignant lesion of esophageal adenocarcinoma.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Intestinal Metaplasia
- Trial name
- NCT01374074
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of North Carolina, Chapel Hill
Gastroesophageal Reflux Disease
Drug Interaction Study Between AZD3355 and Nexium
The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
- Trial name
- NCT00684190
- Testing
- AZD3355, Esomeprazole
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Tooth Wear, Reflux Acid
7 Year Follow up Analysis on the Speed of Progression of Tooth Wear Using 3D Subtraction
Prospective observational study with 7-year follow up. 55 patients are included with moderate to severe tooth wear, whereby through informed consent the decision was taking to monitor the patients.
- Conditions
- Tooth Wear, Reflux Acid, Bruxism
- Trial name
- NCT04790110
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Erosive Esophagitis(EE), Gastroesophageal Reflux Disease (GERD)
TAK-438 - Safety, Blood Levels & Effects of Repeated Doses
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of TAK-438 in healthy, non-Japanese men male subjects following a randomized, double blind, placebo controlled, sequential panel…
- Trial name
- TAK-438_107 (NCT02141711)
- Testing
- TAK-438
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Takeda
Gastroesophageal Reflux
The Detection of Barrett's Esophagus by Gastrointestinal Endoscopy Prevents Esophageal Carcinoma in Morbid Obese After Sleeve Gastrectomy
Severe Gastroesophageal reflux disease (GERD) leading to a chronic aggression of esophagus mucosa, called Barrett's esophagus is a main complication of Sleeve gastrectomy for morbid obesity.
- Trial name
- Refleeve (NCT03596411)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gastroesophageal Reflux Disease (GERD)
Safety and Efficacy of AST-120 in Patients With GERD Who Continue to be Symptomatic on a Standard Dose of PPI
The purpose of this project is to test how safe and how well AST-120, an investigational product, works in treating too much acid in the stomach.
- Trial name
- NCT00587275
- Testing
- AST-120, Celphere CP-305
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ocera Therapeutics
Gastro Esophageal Reflux
A Placebo Controlled Trial With Baclofen for the Treatment of GERD Patients With Incomplete PPI Response
Reflux (acid and non-acid) mainly occurs during transient LES relaxations (TLESRs). The gamma-aminobutyric acid (GABA) receptor type B agonist baclofen was shown to inhibit TLESRs, thereby significantly decreasing acid reflux…
- Trial name
- NCT03835442
- Testing
- Baclofen
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux Disease, Laparoscopic Antireflux Surgery
Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized Trial
The aim of this study is to compare subjective and objective outcome and surgical "side effects" of Nissen and Toupet fundoplication performed in a single institution by only two surgeons and to compare pre and postoperative…
- Trial name
- NCT01321294
- Testing
- laparoscopic anti-reflux surgery
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Gastroesophageal Reflux Disease (GERD)
PDO Thread Embedding Plus Binh Vi Tablets for Gastroesophageal Reflux Disease
The goal of this clinical trial is to learn if PDO thread embedding combined with Binh Vi tablets and Esomeprazole works better than Binh Vi tablets and Esomeprazole alone in treating gastroesophageal reflux disease (GERD) in…
- Trial name
- NCT07910656
- Testing
- PDO Thread Embedding, Esomeprazole 40 mg Oral Tablet, Binh Vi Tablets
- Where
- Vietnam
- Volunteers
- 86 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Gastroesophageal Reflux Disease (GERD)
Assessment of the Role of Tegaserod Therapy in the Management of Gastroesophageal Reflux Disease (GERD) Symptoms in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).
Study to assess the effects of tegaserod added to PPI therapy in the resolution of heartburn and regurgitation in patients with incomplete relief from PPIs .
- Trial name
- NCT00171483
- Testing
- Tegaserod
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Novartis
Laryngopharyngeal Reflux
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin
It is postulated that the incompetence of the upper esophageal sphincter (UES) to restrict passage of esophageal refluxate is fundamental to the development of LPR.
- Trial name
- NCT02552966
- Testing
- UESAD
- Volunteers
- 20 people
- Sponsor
- Northwestern University
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