Clinical trials: Gastrointestinal Reflux
GERD
Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-steroidal Anti-inflammatory Drug (NSAID) Use
The purpose of the study is to examine the impact of augmented, high-quality physician-coordinated care executed via an electronic health record (EHR)-based intervention on quality of care for gastroesophageal reflux disease…
- Trial name
- NCT00691171
- Volunteers
- 5,234 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux, Respiratory Aspiration
Cromolyn Detection of Silent Aspiration
The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract.
- Conditions
- Gastroesophageal Reflux, Respiratory Aspiration, Idiopathic Pulmonary Fibrosis, Lung Transplantation
- Trial name
- NCT01841307
- Testing
- Cromolyn Sodium
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gastroesophageal Reflux Disease
Cognitive Behavioral Therapy for Insomnia (CBTI) in GERD Patients With Insomnia
This study will enroll patients with persistent reflux symptoms despite proton-pump inhibitor therapy and chronic insomnia. Participants that are eligible for the study and agree to participate will receive cognitive behavioral…
- Trial name
- NCT03904472
- Testing
- Web-based CBTI
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Dysphagia
Influence of Oesophageal Contractile Reserve in High Resolution Manometry on Post Operative Dysphagia After Anti-reflux Surgery
The main objective of this study is to evaluate, in a prospective cohort, the link between preoperative contractile reserve of oesophagus evaluated by high resolution manometry (HRM) and the occurrence of post operative dysphagia…
- Trial name
- NCT03374930
- Testing
- Multiple rapid swallows test
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Poitiers University Hospital
Barrett's Esophagus
Comparative Effectiveness of Endoscopic Assessment of Gastroesophageal Reflux and Barretts Esophagus
The hypothesis of this study was that the comparative effectiveness of unsedated transnasal endoscopy (uTNE) will be greater than sedated endoscopy (sEGD) in population screening for BE.
- Trial name
- challenge (NCT01288612)
- Testing
- Sedated Endoscopy, Transnasal Endoscopy
- Where
- United States
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastro-esophageal Reflux
Influence of Expiration Lente Prolongée on Gastro-oesophageal Reflux
The purpose of this study is to determine whether a specific airway clearance technique, l'Expiration Lente Prolongée (ELPr), induces or aggravates gastro-oesophageal reflux in infants under the age of one year.
- Trial name
- NCT03341585
- Testing
- expiration lente prolongée
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Vrije Universiteit Brussel
Refractory GERD, NERD
Vonoprazan Test for PPI Refractory GERD
Among patients suffering from gastroesophageal reflux disease (GERD) symptoms, esophageal pH monitoring and the assessment of symptom-reflux correlation can identify two distinct subgroups characterized by normal acid exposure…
- Conditions
- Refractory GERD, NERD, PCAB
- Trial name
- NCT07437768
- Testing
- Patients received a 4-week treatment of vonoprazan 20 mg once daily (VOCINTI®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT01048840
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Erosive Esophagitis, GERD
Efficacy Study of Ilaprazole to Treat Erosive Esophgitis
This study compared Ilaprazole 20mg with lansoprazole 30mg for the healing of erosive esophagitis and resolution of heartburn.
- Trial name
- NCT01509261
- Testing
- Ilaprazole, Lansoprazole
- Where
- 19 sites in South Korea
- Volunteers
- 292 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Regurgitation, Gastric, Diarrhea
To Assess the Safety and Tolerance of Infant Formula With Locust Bean Gum in Infants With Regurgitation
A randomized, controlled study to evaluate the safety and tolerance of an infant formula with locust bean gum in infants with regurgitation. (Solar)
- Trial name
- Solar (NCT04042454)
- Testing
- milk based anti-regurgitation infant formula, Milk based infant formula
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Esophageal Cancer
Quality of Life After Esophagectomy for Cancer
The purpose of the current study is to assess the role of pyloric drainage procedure on altering the reflux effect on the quality of life in patients who underwent esophagectomy.
- Trial name
- NCT00798746
- Testing
- Telephone Questionnaire
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- M.D. Anderson Cancer Center
Gastroesophageal Reflux, Feeding Disorder
Mic-Key Versus Mini One Family Preference Comparison
The objective of this study is to compare two low profile balloon gastrostomy button enteral feeding devices, both currently used as standard of medical care.
- Conditions
- Gastroesophageal Reflux, Feeding Disorder, Family Satisfaction
- Trial name
- MicKeyVMini (NCT03041649)
- Testing
- GT button change - Mic-Key, GT button change - Mini One
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Children's Mercy Hospital Kansas City
Residual Gastric Contents, Pulmonary Aspiration of Gastric Contents
Effect of Fasting Recommendations Among Patients Using GLP-1 Receptor Agonists
The aim of this randomised controlled trial is to determine the effect of a 24-hour clear liquid diet compared to standard fasting guidelines on the proportion of participants who present with increased residual gastric contents…
- Trial name
- NCT06839248
- Testing
- 24-hour clear liquid diet, Standard fasting guidelines
- Where
- 2 sites in Australia
- Volunteers
- 154 people
- Sponsor
- St Vincent's Hospital Melbourne
Gastroesophageal Reflux Disease
A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)
The purpose of the study is to evaluate efficacy and safety of arbaclofen placarbil (XP19986) versus placebo as adjunctive therapy in subjects with troublesome GERD symptoms despite therapy with approved doses of a Proton Pump…
- Trial name
- NCT00978016
- Testing
- arbaclofen placarbil-Cohort 1, arbaclofen placarbil-Cohort 2, arbaclofen placarbil-Cohort 3
- Where
- 64 sites in United States, Canada
- Volunteers
- 460 people
- Sponsor
- XenoPort, Inc.
Achalasia, Gastroesophageal Reflux
ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia
The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy.
- Trial name
- ARAT (NCT04065516)
- Testing
- ARAT technique
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
GERD
A Study to Evaluate the PK, PD and Safety of CKD-382 in Healthy Subjects
to evaluate the pharmacokinetics, pharmacodynamics and safety after single/multiple administration of CKD-382, D860 and D027 in healthy subjects
- Trial name
- NCT05108038
- Testing
- CKD-382, D860, D027
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastric Cancer, Reflux Esophagitis
Preliminary Efficacy Analysis of Cheng's Giraffe Reconstruction After Proximal Gastrectomy
In the past years, the adenocarcinoma of the esophagogastric junction (AEG) has been increasing obviously in China. It may be caused by the reason of increased body weight, alcohol consumption, gastroesophageal reflux disease and…
- Trial name
- NCT04657848
- Testing
- proximal gastrectomy combined with Cheng's Giraffe reconstruction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Gastroesophageal Reflux, Apneas
Effects of Non-Nutritive Sucking on Gastroesophageal Reflux and Related Apneas in Symptomatic Preterm Infants
Gastro-esophageal reflux (GER) is a common condition among preterm infants, due to several physiological promoting factors. To limit the potentially harmful widespread of pharmacological treatment, a step-wise approach, which…
- Conditions
- Gastroesophageal Reflux, Apneas, Bradycardia
- Trial name
- NNS-GER-SO (NCT02023216)
- Testing
- Pacifier
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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