Clinical trials: Gastrointestinal Surgery
GERD
Multi-Center Study of the NDO Surgical Plicator Utilizing Multiple Implants for the Treatment of GERD
The purpose of this study was to evaluate the safety and efficacy of placing multiple transmural sutures for the treatment of GERD.
- Trial name
- NCT00586859
- Testing
- NDO Full-thickness Plicator
- Where
- 4 sites in Germany
- Volunteers
- 41 people
- Sponsor
- NDO Surgical, Inc.
Non-Alcoholic Fatty Liver Disease
NAFLD Study: US vs Liver Biopsy
Evaluate the diagnostic accuracy of the new ultrasound software vs hepatic histology, the current reference standard for the diagnosis of NAFLD and NASH in 20 obese patients (BMI> 30) candidates for laparoscopic bariatric surgery…
- Trial name
- NAFLD (NCT04101162)
- Testing
- shear waves elastography; liver biopsy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Head Neck Cancer, Oral Cancer
Swallowing Function in Patients With Head and Neck Cancers
Head and neck cancer (HNC) is the sixth most common cancer worldwide, accounting for 2.8% of all malignancies. The presence of tumor itself, as well as the treatment, can result in neuromuscular damage affecting any stage of the…
- Trial name
- NCT05833841
- Testing
- Surface Electromyography and Video fluoroscopy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Banaras Hindu University
Peritoneal Inflammation
Humidification in Laparoscopic Colonic Surgery
Laparoscopic surgery allows surgeons to remove bowel via small incisions. To allow insertion of a camera and instruments, cold and dry gas is blown into the abdominal cavity.
- Trial name
- NCT00642005
- Testing
- Fisher and Paykel Humidifier (MR860), Standard insufflation
- Where
- 3 sites in New Zealand
- Volunteers
- 82 people
- Sponsor
- University of Auckland, New Zealand
NAFLD, Obesity, Adolescent
Impact of Weight Loss Surgery in Adolescents With NAFLD
This study will assess the impact of weight loss surgery (WLS) on non-alcoholic fatty liver disease (NAFLD) in adolescents as well as the interaction between NAFLD and cardiometabolic risk.
- Trial name
- AWLS (NCT02952170)
- Testing
- MRI
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Epidemiological Study to Monitor Study Participants With Resected Stage II (High Risk) or Stage III Colorectal Cancer for Circulating Tumor DNA Before, During and After Their Treatment With Adjuvant Chemotherapy
This is a multi-site epidemiological study designed to monitor circulating tumor DNA (ctDNA) status in participants with Stage II (high risk)/III colorectal cancer (CRC) following resection/prior to adjuvant chemotherapy (AdCTx)…
- Trial name
- NCT04813627
- Testing
- Regular blood sample collection for ctDNA assessment
- Where
- 74 sites in United States, Belgium and 2 more
- Volunteers
- 2,079 people
- Sponsor
- BioNTech SE
Chronic Upper Gastrointestinal Hemorrhage
Enteric Immune-nutrition Formula (ANOM®) for Patients Receiving Major Upper Gastrointestinal Surgery
Perioperative usage of immunonutrition (ANOM®) can attenuate the pro-inflammatory cytokines and reduce postoperative infectious complications and length of hospital stay after major upper gastrointestinal surgery.
- Trial name
- ANOM (NCT01351883)
- Testing
- ANOM
- Where
- 2 sites in Taiwan
- Volunteers
- 64 people
- Sponsor
- National Cheng-Kung University Hospital
Colorectal Cancer, Imaging
Metabolism Imaging-genomics for Predicting the Surgical Outcomes of Colorectal Cancer
In this study, the investigators constructed an imaging-metabolism prediction model for colorectal cancer by analysing the imaging and metabolomics features of colorectal cancer, in order to further adjust and guide the treatment…
- Conditions
- Colorectal Cancer, Imaging, Metabolomics, Prognosis
- Trial name
- NCT06614660
- Testing
- Metabolism genomics and imaging genomics
- Where
- China
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Gastric Cancer (GC), HIPEC
Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer
The study investigates the outcomes of hyperthermic intraperitoneal chemoperfusion (HIPEC) in combination with curative-intent gastrectomy in resectable locally-advanced and limited-metastatic (low peritoneal cancer index)…
- Conditions
- Gastric Cancer (GC), HIPEC, Peritoneal Metastases From Gastric Cancer, Hyperthermic Intraperitoneal Chemoperfusion
- Trial name
- G-PEC (NCT07313579)
- Testing
- curative-intent surgery + HIPEC
- Where
- Ukraine
- Volunteers
- 200 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Gastric Cancer
Fast Track Surgery With Laparoscopic-assisted Gastrectomy for Advanced Gastric Cancer: a Randomized Controlled Trial
The purpose of this study is to to investigate the feasibility and safety of fast-track surgery when combined with laparoscopic-assisted gastrectomy for advanced gastric cancer patients.
- Trial name
- FTSlapAG (NCT01955096)
- Testing
- fast-track surgery, conventional postoperative care
- Volunteers
- 61 people
- Sponsor
- Quan Wang
Hiatal Hernia, GERD
Laparoscopic Total Left-sided Surgical Approach Versus Traditional Bilateral Surgical Approach for Hiatal Hernia
Background: In China, guidelines for the treatment of hiatal hernia (HH) are lacking. Furthermore, efficacy and safety assessments of surgical approaches for HH and for the protection of the vagus nerve and organ function are…
- Trial name
- NCT06828627
- Testing
- TLSA, TBSA
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer
da Vinci SP Robotic Gastrectomy
Laparoscopic surgery revolutionized the surgical treatment of gastric cancer saving large incsion and associated pain. Robotic surgical system was introduced to enhance the minimally invasive surgery using articulating robotic…
- Trial name
- NCT05051670
- Testing
- da vinc SP gastrectomy
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Yonsei University
Colorectal Cancer, Surgery
Cardiopulmonary Exercise Test Data Averaging Methods and Preoperative Risk Assessment
Cardiopulmonary exercise testing (CPET) is used for preoperative risk assessment in patients with colorectal cancer who need to undergo surgery.
- Conditions
- Colorectal Cancer, Surgery, Colorectal Neoplasms Malignant
- Trial name
- NCT05353127
- Testing
- CPET/Cardiopulmonary Exercise Test
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- VieCuri Medical Centre
Pancreatic Cancer
Vaccine Treatment for Surgically Resected Pancreatic Cancer
This 2-phase study will determine the safety of treating patients with pancreatic cancer with the genetically engineered HyperAcute-Pancreatic cancer vaccine.
- Trial name
- NCT00255827
- Testing
- HyperAcute-Pancreatic Cancer Vaccine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- NewLink Genetics Corporation
Crohn's Disease
The Efficacy of Enteral Nutrition in Fill of the Treatment Blank Period of the Postoperative Maintain Remission Medication for Crohn's Disease (CD)
Crohn's disease(CD) is a agnogenic disease which has a lifelong relapse tendency even after surgery treatment.So maintain remission medications were routinely given to patients after surgery.But maintain remission medications,as…
- Trial name
- NCT01823042
- Testing
- azathioprine+enteral nutrition, Azathioprine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Gallstone Disease, Ultrasonic Diagnosis
Transabdominal and Laparoscopic Ultrasound in a Bariatric Setting
Every year, many patients undergo weight-loss (bariatric) surgery. While this surgery leads to significant and intended weight loss, it also increases the risk of developing gallstones or other gallbladder problems.
- Conditions
- Gallstone Disease, Ultrasonic Diagnosis, Bariatric Patients Undergoing Bariatric Surgery
- Trial name
- NCT07453186
- Testing
- Diagnostic procedures
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Rectal Cancer
Prehabilitation During Neoadjuvant Chemoradiotherapy for Rectal Cancer
The purpose of this study is determine whether a trimodel prehabilitation program (combined with physical exercise, nutrition supplement and mental support) during neoadjuvant chemoradiotherapy can help patients with rectal…
- Trial name
- NCT06542354
- Testing
- Physical exercise, Nutrition supplement, Mental support
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Fudan University
Peritoneal Metastases, Peritoneal Carcinomatosis
Changes in Coagulation in Colorectal Cancer Patients Undergoing Surgical Treatment
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has prolonged the survival substantially for selected patients with peritoneal metastases from colorectal cancer.Bleeding and thromboembolic disease…
- Conditions
- Peritoneal Metastases, Peritoneal Carcinomatosis, Colorectal Neoplasms Malignant, Intestinal Neoplasms
- Trial name
- CONTEST (NCT04744688)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Pancreatic Cancer
Gemcitabine and Erlotinib Before and After Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
PURPOSE: This phase II trial is studying how well gemcitabine and erlotinib work when given before and after surgery in treating patients with pancreatic cancer that can be removed by surgery.
- Trial name
- NCT00733746
- Testing
- erlotinib hydrochloride, gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- 24 sites in United States, Canada
- Volunteers
- 123 people
- Sponsor
- Alliance for Clinical Trials in Oncology