Clinical trials: Gastrointestinal Tract
Digestion
Beef Versus Whey Protein: The Gut Showdown Self-Experiment
Test whether a doctor-formulated protein made from real beef is more digestible than standard whey protein powder. For the first 30 days, participants receive either standard whey protein powder or Equip Protein and track how the…
- Trial name
- NCT07477223
- Testing
- Beef protein, Chocolate whey protein
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Autism Spectrum Disorder
Gut Microbiome Characteristics and Neurodevelopmental Functioning in Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that affects communication, behavior, sensory processing, and daily functioning.
- Trial name
- GAIN-ASD (NCT07646808)
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Saveetha University
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity
Gut Microbiota Composition in Hispanic and Non-Hispanic Children.
The human gastrointestinal (GI) tract is filled with millions of bacteria that can affect our health. These bacteria are linked with our overall health including obesity risk.
- Trial name
- NCT03990350
- Testing
- Fecal Sample Collection, Physical Activity Questionnaire, Food Frequency Questionnaire
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Cancer, Solid Tumor
ACTolog in Patients With Solid Cancers
The study purpose is to learn about the safety and tolerability of IMA101 alone (Cohort 1) or in combination with atezolizumab (Cohort 2) in patients with advanced solid cancers that express pre-defined Immatics tumor targets.
- Trial name
- ACTolog (NCT02876510)
- Testing
- Fludarabine, Cyclophosphamide, IMA101 product
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Immatics US, Inc.
Glucose Metabolism Disorders, Obesity
Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery
The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.
- Conditions
- Glucose Metabolism Disorders, Obesity, Sleeve Gastrectomy, Gastric Bypass
- Trial name
- Obesity (NCT04082923)
- Testing
- Liquid meal, Solid meal
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity
Effects of Benaglutide on Weight and Gut Microbiota in Obese Patients
The purpose of this studay is to evaluate the effects of Benaglutide on the treatment of subjects with obesity.
- Trial name
- NCT03986008
- Testing
- Benaglutide, Liraglutide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiangya Hospital of Central South University
Laparoscopy, Laparotomy
Gut Oxygenation and Laparoscopy
Patients with left-colon cancer will be randomized to laparoscopic or laparotomic operation. during surgery and for 6 days after operation, intestinal oxygen tension and ischemia-reperfusion injury markers will be evaluated to…
- Conditions
- Laparoscopy, Laparotomy, Oxygenation,, Ischemia-Reperfusion Injury
- Trial name
- NCT01040013
- Testing
- Laparoscopy, left colectomy by laparotomy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milano Bicocca
Biliary Tract Cancer
MiniPDX-based Postoperative Adjuvant Therapy for Biliary Tract Cancer
This research aims to study the effect of postoperative adjuvant therapy with a MiniPDX drug sensitivity test for biliary tract cancer.
- Trial name
- NCT07156058
- Testing
- MiniPDX group, Capecitabine
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Laparoscopic Surgery, Pneumoperitoneum
Low-pressure vs Standard-pressure in Laparoscopic Cholecystectomy
Background. Many studies have demonstrated reduced postoperative pain in patients undergoing lower pneumoperitoneum pressure level during laparoscopic cholecystectomy.
- Conditions
- Laparoscopic Surgery, Pneumoperitoneum, Cholecystitis; Choledocholithiasis, Quality of Life
- Trial name
- NCT04146090
- Testing
- Low-pressure pneumoperitoneum, Standard pressure pneumoperitoneum
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Regurgitation, Gastric
Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric Emptying
The primary objective of this trial is to show that an hypoallergenic infant starter formula containing starch and the probiotic L.
- Trial name
- NCT01956682
- Testing
- HA formula + starch + L. reuteri
- Where
- Italy
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Bari
Cholecystitis, Acute
Bile Aspiration vs Drain in Acute Cholecystitis
In order to compare percutaneous cholecystostomy and leaving a drain in situ with percutaneous gallbladder aspiration we plan to undertake a double-blind randomized controlled trial.
- Trial name
- NCT03012243
- Testing
- Gallbladder aspiration, Cholecystostomy
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Healthy, Pulmonary Fibrosis
Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA).
- Conditions
- Healthy, Pulmonary Fibrosis, Rheumatoid Arthritis
- Trial name
- NCT00001885
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Gallbladder Cancer
Predicting Incidental Gallbladder Cancer
The goal of this observational study is to identify risks factors for incidental (unexpected) gallbladder cancer in adult patients undergoing routine gallbladder surgery (cholecystectomy) for conditions such as gallstones or…
- Trial name
- P-iGBC (NCT06531408)
- Where
- United Kingdom
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Breast Cancer, Gut Microbiome
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors
The primary goal of this project is to determine the effects of exercise on the gut microbiome in breast cancer survivors and determine how these changes may relate to psychosocial symptoms such as fatigue.
- Conditions
- Breast Cancer, Gut Microbiome, Exercise, Fatigue
- Trial name
- ROME (NCT04088708)
- Testing
- Aerobic Exercise Training, Attention Control
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Alabama at Birmingham
Advanced Solid Tumor, Colorectal Cancer
A Study of KF-0210 in Advanced Solid Tumors Patients
The purpose of this Phase I, Multi-Center, Open-Label Study is to evaluate the safety, tolerability, Pharmacokinetics, Pharmacodynamics and anti-tumor activity of KF-0210 in participants with advanced solid tumors.
- Conditions
- Advanced Solid Tumor, Colorectal Cancer, Lung Cancer, Squamous Cell Carcinoma of the Esophagus
- Trial name
- NCT04713891
- Testing
- KF-0210 tablets, 120 mg, KF-0210 tablets, 240 mg, KF-0210 tablets, 450 mg
- Where
- Australia
- Volunteers
- 14 people
- Sponsor
- Keythera Pharmaceuticals (Australia) Pty Ltd
Healthy Volunteer
A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers
This is a randomized (1:1), double-blind, double-dummy, phase I study to compare the effects of Omadacycline versus Moxifloxacin on gut microbiota and the resistomes in healthy adult volunteers.The study consists of 3 phases…
- Trial name
- NCT06462326
- Testing
- Moxifloxacin Oral Tablet, Omadacycline Oral Tablet
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zai Lab (Hong Kong), Ltd.
Acute Coronary Syndrome
Impact of Traditional Chinese Medicine on the Gut Microbiota-dependent Trimethylamine N-oxide
Recent studies highlight the participation of gut microbes in the pathogenesis of both atherosclerotic heart disease and its adverse thrombotic events.
- Trial name
- TCM-TMAO (NCT03186625)
- Testing
- Compound Panax Notoginseng Granule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Biliary Tract Disease
Clinical Utility of ERCP Guided Cholangiopancreatoscopy With the SpyGlass DS
This is a prospective evaluation of the clinical utility of the new cholangioscopy platform SpyGlass DS. The aims of this study are to prospectively document the clinical utility and technical aspects of ERCP with cholangioscopy…
- Trial name
- SPYDS (NCT02524418)
- Testing
- Cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Florida
Biliary Tract, Neoplasms
Clinical Evaluation of a Custom-made and Disposable Endoscope System for Biliary Tract
A disposable endoscopy system (NCKU-scope-01) was developed for the evaluation of bile duct stone or neoplasm. This system consists of a camera, light sources, a working channel, and a water injection channel.
- Conditions
- Biliary Tract, Neoplasms, Stone - Biliary
- Trial name
- NCT04456218
- Testing
- NCKU-scope-01 (a custom-made biliary endoscope system)
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- National Cheng-Kung University Hospital
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