Clinical trials: Gastrointestinal Tumor Surgery
Pancreatic Cancer, Vascular
NON-INVASIVE BLOOD FLOW ASSESSMENT: Computational Tool for Measuring Arterial Flow From CT
Major invasive surgery, such as oncological abdominal surgery, is associated with a high risk of complications and mortality. One of the main problems in this type of surgery is the difficulty in preserving the arteries and veins…
- Conditions
- Pancreatic Cancer, Vascular, Surgical Planning
- Trial name
- NOVELLA (NCT07155616)
- Testing
- Blood flow measurement
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Clinic of Barcelona
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Thalidomide and Chemoembolization With Doxorubicin in Treating Patients With Liver Cancer That Cannot be Removed by Surgery
This phase II trial is studying the effectiveness of combining thalidomide and chemoembolization in treating patients who have liver cancer that cannot be removed by surgery.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer
- Trial name
- NCT00006016
- Testing
- thalidomide, doxorubicin hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing…
- Trial name
- NCT00335816
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 15 sites in United States, Canada
- Volunteers
- 248 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Urinary Retention, Rectal Cancer
Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2)
The objective of this trial is to investigate the effect of bladder training on the incidence of re-catheterization after proctectomy.
- Conditions
- Urinary Retention, Rectal Cancer, Urinary Catheterization
- Trial name
- NCT06217016
- Testing
- ICCAUT, Free drainage
- Where
- China
- Sponsor
- The First Hospital of Jilin University
Pancreatic Cancer
Combination Chemotherapy Followed by Chemotherapy and Radiation Therapy and/or Surgery in Treating Patients Who Have Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug with radiation therapy and/or surgery may kill more tumor cells.
- Trial name
- NCT00003332
- Testing
- cisplatin, gemcitabine hydrochloride, surgical procedure
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- NYU Langone Health
Esophageal Squamous Cell Carcinoma
Candonilimab (AK104) Plus Preoperative Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma (ESCC)
This is a prospective, single-arm, open-label，multi-center, phase II study, aiming to evaluate the efficacy and safety of AK104 combined with preoperative chemotherapy in patients with locally advanced ESCC.
- Trial name
- NCT05896787
- Testing
- AK104, nab-paclitaxel, carboplatin
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Colorectal Cancer, Colon Rectal Resection
Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer
Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal…
- Conditions
- Colorectal Cancer, Colon Rectal Resection, Oxidative Stress
- Trial name
- NCT01470586
- Testing
- Surgery for colorectal cancer
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. Hatzikosta General Hospital
Esophageal Carcinoma
Staging and Outcome Depending on Surgical Treatment in Adenocarcinomas of the Oesophagogastric Junction
Background: Owing to controversial staging and classification of adenocarcinoma of the oesophagogastric junction (AOG) before surgery, the choice of appropriate surgical approach remains problematic.
- Trial name
- NCT01766986
- Volunteers
- 130 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastric Cancer
Impact of Preoperative VFA on Intraoperative Adverse Events in Patients Undergoing Laparoscopic Radical Gastrectomy
Preoperative visceral fat area (VFA) is associated with an increased incidence of postoperative complications in gastric cancer (GC). However, the relationship between VFA and intraoperative adverse events (iAEs) remains unclear.
- Trial name
- NCT06506331
- Volunteers
- 490 people
- Sponsor
- Fujian Medical University
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
This phase I/II trial is studying the side effects and best dose of belinostat and to see how well it works in treating patients with liver cancer that cannot be removed by surgery.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00321594
- Testing
- belinostat
- Where
- 2 sites in United States, Singapore
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Gastric Adenocarcinoma, Oligometastasis
Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer
This phase II trial studies how well chemotherapy with or without radiation or surgery works in treating participants with esophageal or gastric cancer that has spread to less than 3 places in the body (oligometastatic).
- Conditions
- Gastric Adenocarcinoma, Oligometastasis, Stage IV Esophageal Adenocarcinoma AJCC v7, Stage IV Esophageal Cancer AJCC v7
- Trial name
- NCT03161522
- Testing
- Capecitabine, Chemotherapy, Conventional Surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Gallstones, Gastric Cancer
The Incidence of Gallstones After Gastric Cancer Surgery
Through previous clinical observations and literature, we found that the incidence of gallstones in patients after gastric cancer radical resection was significantly higher than that in the normal population (4%).
- Trial name
- NCT04250402
- Testing
- Resection
- Where
- 2 sites in China
- Volunteers
- 1,019 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Colorectal Cancer
SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002551
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Where
- 37 sites in United States, Canada and 1 more
- Volunteers
- 1,917 people
- Sponsor
- SWOG Cancer Research Network
Rectal Cancer, Quality of Life
Quality of Life in RECTal Cancer - a Prospective Multicenter Cohort Study
Rectal cancer is a common type of cancer occuring more frequently in men but also common in women. Almost 60% of the patients survive 5-years and the treatment has been continuously developed in the last three decades.
- Conditions
- Rectal Cancer, Quality of Life, Surgery
- Trial name
- QoLiRECT (NCT01477229)
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Liver Neoplasms, Hepatectomy
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as…
- Conditions
- Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PRICE2 (NCT03651154)
- Testing
- Hypovolemic Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Ottawa Hospital Research Institute
Colorectal Cancer
The Prognosis of Colorectal Cancer Patients After Indocyanine Green Fluorescence-guided Radical Surgery
Previous studies of Indocyanine green (ICG) in colorectal surgery have focused on lymphatic mapping, lymph node detection, and the number of harvested lymph nodes.
- Trial name
- NCT06508541
- Testing
- ICG Guided surgery, conventional surgery
- Where
- China
- Volunteers
- 235 people
- Sponsor
- Shanghai Tong Ren Hospital
Colorectal Cancer, Gastric Cancer
Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease
The purposes of this study are to collect and store samples including blood, normal and tumor tissue from patients with colorectal cancer or gastric cancer, to collect and store samples including blood and/or normal…
- Conditions
- Colorectal Cancer, Gastric Cancer, Inflammatory Bowel Diseases, Gastric Ulcer
- Trial name
- NCT03972956
- Testing
- No intervention will be given to patients.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Liver Cancer, Metastatic Cancer
Cryosurgery in Treating Patients With Liver Cancer or Liver Metastases
RATIONALE: Cryosurgery kills cancer cells by freezing them during surgery. PURPOSE: Phase I/II trial to study the effectiveness of cryosurgery in treating patients with unresectable primary liver cancer or liver metastases.
- Trial name
- NCT00002655
- Testing
- cryosurgery
- Where
- United States
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Colectomy
Randomised Trial of Doppler-Optimised Fluid Balance in Elective Colectomy
Perioperative fluid management has been historically dictated by outdated, contradictory concepts. Excessive or inadequate fluid administration around surgery is deleterious and hence goal-directed fluid therapy using Oesophageal…
- Conditions
- Colorectal Cancer, Colectomy, Surgery, Perioperative Care
- Trial name
- NCT00911391
- Testing
- Oesophageal Doppler, Intraoperative fluid restriction
- Where
- 2 sites in New Zealand
- Volunteers
- 85 people
- Sponsor
- University of Auckland, New Zealand
Intestinal Cancer, Diverticulitis
Using Electrical Bioimpedance Assessments to Estimate Perioperative Total Body Water and Postoperative Fluid Need
Being able to accurately monitor patient bodily fluid levels during and after surgery is very important, as there are a number of complications that can arise if a patient's fluid levels become unbalanced, such as swelling within…
- Conditions
- Intestinal Cancer, Diverticulitis, Pancreatic Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT02200055
- Testing
- Bodystat Quadscan 4000
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- United States Naval Medical Center, Portsmouth
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