Clinical trials: Gastrointestinal Tumor Surgery
Pancreatic Cancer, Surgery
Quality of Life in Elderly Patients After Pancreatic Cancer Surgery
Pancreatic cancer mainly affects the elderly, with over 85% of patients diagnosed after the age of 60 and over half after the age of 70.
- Conditions
- Pancreatic Cancer, Surgery, Elderly
- Trial name
- ADL_DPC_PA (NCT06079229)
- Testing
- Phone call
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Pancreatic Cancer, Pancreatic Cancer Non-resectable
Surufatinib Combined With Gemcitabine Plus Nab-paclitaxel in Locally Advanced Pancreatic Cancer
To evaluate the efficacy and safety of surufatinib combined with gemcitabine plus nab-paclitaxel in patients with locally advance d pancreatic cancer
- Conditions
- Pancreatic Cancer, Pancreatic Cancer Non-resectable, Pancreatic Ductal Adenocarcinoma, PDAC
- Trial name
- NCT06361030
- Testing
- surufatinib combined with gemcitabine plus nab-paclitaxel
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colonic Neoplasms, Colorectal Neoplasms
Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer
The primary objective is to assess and characterize the antitumor activity and safety and tolerability of adjuvant treatment with an individualized neoantigen vaccine called GRT-C901/GRT-R902 (chimpanzee adenovirus [ChAd] and…
- Trial name
- NCT05456165
- Testing
- GRT-C901, GRT-R902, Atezolizumab
- Where
- 3 sites in United States
- Sponsor
- Gritstone bio, Inc.
Hepatocellular Carcinoma, Liver Cirrhosis
Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular Carcinoma in Cirrhotic Liver
The purpose of this study is to assess the safety of transarterial radioembolization prior to surgical resection or radiofrequency in cirrhotic patients with hepatocellular carcinoma
- Trial name
- TRYPHON (NCT01686880)
- Testing
- Sirsphere trans-arterial radioembolization
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Jules Bordet Institute
Surgical Site Infections, Colorectal Cancer
Risk Factor Assessment for the Development of Surgical Site Infection in Patients Undergoing Colorectal Cancer Surgery
Surgical site infection (SSI) is a common complication following colorectal cancer (CRC) surgery and represents a significant cause of slower postoperative recovery and prolonged hospital stay.
- Trial name
- NCT07104903
- Testing
- Data collection from medical records
- Where
- Serbia
- Volunteers
- 62 people
- Sponsor
- Oncology Institute of Vojvodina
Hepatocellular Carcinoma
Hepatectomy Versus Radiofrequency Ablation for Hepatocellular Carcinoma Adjacent to Major Blood Vessels
This study will compare and analyze the difference between hepatectomy at deep and complex sites(adjacent to major blood vessels) of patients with HCC and PRFA prognosis, recovery after treatment as well as incidence of…
- Trial name
- NCT00814242
- Testing
- surgical resection, percutaneous radiationfrequency ablation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Colorectal Cancer, Surgery
A Cohort of Molecular Characteristics and Prognosis of Colorectal Cancer
This study aims to establish a colorectal cancer cohort, collect clinicopathological information, collect biological samples for multi-omics testing, and perform relevant analysis, to predict the prognosis of colorectal cancer…
- Trial name
- NCT05086601
- Testing
- colorectal cancer surgery
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Fudan University
Liver Neoplasms
Single-probe Microwave Ablation (MWA) of Metastatic Liver Cancer
Microwave ablation (MWA) is the most recent development in the field of local ablative therapies. The aim of this study was to evaluate the variability and reproducibility of single-probe MWA versus radiofrequency ablation (RFA)…
- Trial name
- LiverMWA1 (NCT00922181)
- Testing
- Microwave ablation, Radiofrequency ablation
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Gasthuisberg
Gastric Cancer, Surgery
Phase III Randomized Trial of Adjuvant XP Chemotherapy and XP/RT for Resected Gastric Adenocarcinoma
The objective of the trial is to compare disease-free survival between adjuvant capecitabine/cisplatin alone vs capecitabine/cisplatin with radiotherapy (chemoradiation) in curatively resected gastric cancer patients.
- Trial name
- NCT00323830
- Testing
- Capecitabine, cisplatin, Radiotherapy (+/-)
- Where
- South Korea
- Volunteers
- 458 people
- Sponsor
- Samsung Medical Center
Anastomotic Leak, Colorectal Cancer
Predictors of Rescue Surgery, Mortality, and Permanent Stoma After Anastomotic Leak Following Colorectal Cancer Resection
Anastomotic leakage is a serious complication following colorectal cancer resection and may result in emergency reoperation, severe sepsis, death, loss of the colorectal anastomosis, and formation of a long-term or permanent…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Colon Cancer, Postoperative Complication
- Trial name
- leak predictor (NCT07725692)
- Where
- Egypt
- Volunteers
- 3,200 people
- Sponsor
- Alexandria University
Adenocarcinoma of the Pancreas, Stage IA Pancreatic Cancer
Perioperative Therapy for Resectable Pancreatic Cancer
This phase II trial studies how well giving combination chemotherapy together with intensity-modulated radiation therapy (IMRT) and surgery works in treating patients with localized pancreatic cancer that can be removed by…
- Conditions
- Adenocarcinoma of the Pancreas, Stage IA Pancreatic Cancer, Stage IB Pancreatic Cancer, Stage IIA Pancreatic Cancer
- Trial name
- NCT00609336
- Testing
- gemcitabine hydrochloride, docetaxel, capecitabine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Colonic Neoplasms
Comparative Study of Laparoscopic Versus Open Operations for Colon Cancer
The purpose of this study is to compare the short and long term outcomes of people who have colon cancers removed either by laparotomy (a large cut in the abdominal wall) or by a laparoscopic assisted approach (keyhole surgery).
- Trial name
- NCT00202111
- Testing
- Laparoscopic-assisted colectomy, Conventional open colectomy
- Where
- 20 sites in Australia, New Zealand
- Volunteers
- 600 people
- Sponsor
- The Queen Elizabeth Hospital
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Rectal Neoplasms Malignant, Surgery
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer
Laparoscopic surgery for rectal cancer has been successfully proven to be a non-inferior alternative regarding resection quality, and oncological outcomes of patients as compared to open surgery in mangy clinical trails.
- Trial name
- NCT02966483
- Testing
- TaTME, LpTME
- Where
- 16 sites in China
- Volunteers
- 1,115 people
- Sponsor
- Sun Yat-sen University
Metastatic Colorectal Cancer
Pre- and Postoperative Chemotherapy Including Bevacizumab in Potentially Curable Metastatic Colorectal Cancer
Major attempt is being given to the potential of curing patients with metastatic colorectal cancer due to the recognition of dramatic change in survival figures achieved in palliative chemotherapy combination treatment protocols.
- Trial name
- ASSO-LM1 (NCT00444041)
- Testing
- Bevacizumab
- Where
- Austria
- Volunteers
- 43 people
- Sponsor
- Austrian Society Of Surgical Oncology
Carcinoma, Hepatocellular
Clinical Study of Effectiveness of Radiotherapy Before Surgery in High-risk Relapse Hepatocellular Cancer Patients
This study aims to evaluate the effectiveness of radiotherapy before surgery in high-risk relapse hepatocellular cancer patients.
- Trial name
- NCT02580929
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College
Perioperative Complication
Effectiveness of Intensive Perioperative Nutrition Therapy Among Adults Undergoing Gastrointestinal & Oncology Surgery
Perioperative malnutrition is common in patients undergoing gastrointestinal and oncological surgery and it also associated with longer hospital stays, reduced responses to and increased complications from therapies, increased…
- Trial name
- NCT04347772
- Testing
- Oral Nutrition Support
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Colon Cancer, dMMR Colorectal Cancer
Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers
This is a Phase II, single arm study looking at the rate of major clinical response and non-operative management in Stage II and III colon cancer after 18 weeks (up to 6 cycles) of neoadjuvant dostarlimab.
- Trial name
- NAIO (NCT05239546)
- Testing
- Dostarlimab
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Colorectal Cancer, Ovarian Carcinoma
Intraperitoneal LSTA1 in CRS-HIPEC
This Study is designed to test an investigational product (IP) called LSTA1 (Study drug). LSTA1 is a drug designed to improve the delivery of anti-cancer treatments, such as chemotherapy.
- Conditions
- Colorectal Cancer, Ovarian Carcinoma, Appendix Cancer, Peritoneal Metastases
- Trial name
- NCT06216561
- Testing
- CRS-HIPEC + LSTA1, CRS-HIPEC alone
- Where
- United States
- Sponsor
- University of California, San Diego
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