Clinical trials: Gastrointestinal Tumor Surgery
Pancreatic Cancer
Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas
RATIONALE: Surgery to remove the pancreas, some of the small intestine, and lymph nodes may be more effective treatment for cancer of the pancreas than surgery to remove the pancreas and some of the small intestine alone.
- Trial name
- NCT00003049
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4, Peritoneal Carcinomatosis
Surgery With HIPEC in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
Multicentric randomised trial. The goal of this clinical research study is to learn if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to decrease the rate of peritoneal carcinomatosis(PC) in patients with high risk…
- Trial name
- NCT02179489
- Testing
- Surgery and Hyperthermic Intraperitoneal Chemotherapy with MMC
- Where
- 9 sites in China
- Volunteers
- 271 people
- Sponsor
- Zhejiang University
Colorectal Cancer
To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA Level Increases Again After Colorectal Cancer Surgery
This study is a prospective, observational and exploratory study to explore the effect of Huaier Granule on the negative conversion rate of patients with increased CEA levels after colorectal cancer surgery.
- Trial name
- NCT06665334
- Testing
- Huaier granule
- Volunteers
- 134 people
- Sponsor
- Fudan University
Colorectal Cancer, Colorectal Surgery
Nutritional Supplementation to Improve Colorectal Cancer Surgery
This study aims to explore the effectiveness of perioperative Oral Nutritional Supplementation (ONS) combined with an optimized, tailored diet in reducing the risk of postoperative complications and improving the nutritional…
- Trial name
- NUTRICOLOR (NCT07599501)
- Testing
- Diet Optimization (DO), Oral Nutritional Supplement (ONS)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto Clinico Humanitas
Oropharyngeal Cancer, Dysphagia, Oropharyngeal
Liposomal Bupivacaine and Transoral Robotic Surgery
This study is for patients with oropharyngeal squamous cell carcinoma. We want to learn more about how we can optimize pain control in patients who undergo transoral robotic surgery (TORS) for oropharyngeal squamous cell…
- Conditions
- Oropharyngeal Cancer, Dysphagia, Oropharyngeal, Post Operative Pain, Transoral Robotic Surgery
- Trial name
- NCT05862792
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Geisinger Clinic
Pancreatic Cancer, Pancreatic Cyst
Prevalence and Consequences of Hyperlactemia Following Pancreatic Surgery
The goal of this observational study is to investigate the role of lactate elevation. The main aims are: Determine the frequency of lactate elevation following pancreatic surgery and its relationship to postoperative…
- Conditions
- Pancreatic Cancer, Pancreatic Cyst, Chronic Pancreatitis
- Trial name
- NCT06589102
- Where
- Sweden
- Volunteers
- 491 people
- Sponsor
- Karolinska University Hospital
Pancreatic Neoplasms, Pancreatic Fistula
Preoperative EUS Elastography for Pancreatic Texture and POPF Prediction After PD
This prospective study evaluates whether preoperative endoscopic ultrasound elastography (EUS-E) can predict pancreatic texture during surgery and risk of postoperative pancreatic fistula (POPF) in 100 patients undergoing…
- Trial name
- EUS-E (NCT07139236)
- Testing
- Preoperative Endoscopic Ultrasound Elastography (EUS Elastography)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Oesophageal Carcinoma
Neoadjuvant Epirubicin, Cisplatin and Capecitabine (ECX) Followed by Definitive Chemoradiation With/Without Surgery for Squamous Cell Carcinoma of the Oesophagus
This is a study to investigate the efficacy and safety of epirubicin, cisplatin and capecitabine (ECX) as neoadjuvant therapy prior to radical chemoradiotherapy using capecitabine and cisplatin as radio-sensitisers in patients…
- Trial name
- NCT00220129
- Testing
- Epirubicin, Cisplatin, Capecitabine, Surgical Resection
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Gastric Cancer, Surgical Wound Infection
Fatigue and QoL Among Gastric Cancer Patients Undergoing Abdominal Surgery
Background: Cancer-related fatigue (CRF), one of the indicators of QoL, is one of the most common side effects of cancer and its treatment.
- Conditions
- Gastric Cancer, Surgical Wound Infection, Fatigue, Quality of Life
- Trial name
- NCT03766945
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas
Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With Surgery
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor…
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer, Stage IA Pancreatic Cancer
- Trial name
- NCT01234935
- Testing
- dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis
- Where
- 17 sites in United States
- Volunteers
- 8 people
- Sponsor
- Translational Oncology Research International
Pancreatic Neoplasms, Rectal Neoplasms
Blue and Amber Light Exposure in Patients With Rectal and Pancreatic Cancer
This study will evaluate light therapy used in combination with standard therapies for pancreatic and rectal cancer. Participants will receive chemotherapy, radiation, and surgical treatments identical to that they had not been…
- Trial name
- NCT06164691
- Testing
- Blue light, Amber light, Ambient White Light
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Matthew Neal MD
Colorectal Cancer
a Pilot Study of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery
patients who meet the enrollment criteria will be randomized 1:1:1:1 to the different doses of lidocaine or the placebo group. In the lidocaine groups, at the beginning of surgery, lidocaine 0.5mg/kg, 1.0mg/kg, and 1.5mg/kg per…
- Trial name
- NCT05412576
- Testing
- Lidocaine Hydrochloride 2% Injection Solution, 0.9% NaCl
- Where
- China
- Volunteers
- 220 people
- Sponsor
- West China Hospital
Colon Cancer, Inflammatory Bowel Diseases
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01155440
- Testing
- Lidocaine, Thoracic epidural block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Treatment Side Effects, Colorectal Cancer
Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR
Randomized head-to-head comparison trial among patients who have undergone incomplete endoscopic resection of early colon cancer to evaluate the benefits, harms and burdens, as well as the ecological footprint and…
- Trial name
- SCAR (NCT06057350)
- Testing
- Tumor removal
- Where
- 3 sites in Norway, Poland
- Volunteers
- 304 people
- Sponsor
- Norwegian Department of Health and Social Affairs
Breast Cancer, Colorectal Cancer
Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT) scanning before surgery, may help measure the extent of disease.
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT01254591
- Testing
- 18F-fluoromisonidazole, fluorescence angiography, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College London (UCL) Cancer Institute
Cholangiocarcinoma, Gall Bladder Carcinoma
Precise Treatment System of Biliary Malignancies Based on Special Disease Database
Malignant tumors of biliary system lack standard treatment and precise prognosis assessment methods. This study including 12 hospitals, collecting clinical and follow-up data of patients with biliary malignant tumors including…
- Conditions
- Cholangiocarcinoma, Gall Bladder Carcinoma, Biliary System Disorder
- Trial name
- NCT03499782
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Advanced Malignant Solid Neoplasm, Fibrolamellar Carcinoma
Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of sapanisertib and ziv-aflibercept in treating patients with solid tumors that have come back (recurrent) and have spread to another place in the body (metastatic) or…
- Conditions
- Advanced Malignant Solid Neoplasm, Fibrolamellar Carcinoma, Metastatic Malignant Solid Neoplasm, Ovarian Carcinoma
- Trial name
- NCT02159989
- Testing
- Sapanisertib, Ziv-Aflibercept
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Cancer, Surgery
The Therapeutic Evaluation(Both Short-term and Long-term Outcome) of Minimal Invasive Radical Antegrade Modular Pancreatosplenectomy for Left-sided Pancreatic Cancer Patients
Pancreatic cancer is regarded as "the king of cancer". It is extremely malignant, with a low sensibility to chemotherapy and radiotherapy, and a poor prognosis. Surgical treatment is very important for pancreatic cancer.
- Trial name
- MIRROR (NCT03770559)
- Testing
- Minimal Invasive RAMPS, Open RAMPS
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Peking Union Medical College Hospital
Gastric Cancer
Efficacy of RUS GA Surgical Navigation for Robot-assisted Distal Gastrectomy in Gastric Cancer Patients
This investigator-initiated, randomized superiority clinical trial aims to demonstrate the clinical effectiveness of RUS GA Surgical Navigation, an endoscopic imaging treatment planning software, in patients undergoing…
- Trial name
- NCT06639490
- Testing
- RUS GA, standard treatment
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Colorectal Cancer
Peri-Strips Dry (PSD) Veritas Collagen Matrix Staple Line Reinforcement for Colorectal Surgery
Purpose of the study is to assess the utility of PSD Veritas as a staple line reinforcement to minimize the risk of leakage during or after colo-rectal surgery.
- Trial name
- NCT00559013
- Testing
- Staple line reinforcement
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baxter Healthcare Corporation
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