Clinical trials: Gastrointestinal Tumor Surgery
Gastric Cancer
S-1 and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage III Stomach Cancer
RATIONALE: Drugs used in chemotherapy, such as S-1 and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00182611
- Testing
- cisplatin, tegafur-gimeracil-oteracil potassium, adjuvant therapy
- Where
- 6 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Kyoto University
Colo-rectal Cancer
Multicentric National Italian Analysis of Textbook Outcome in Colorectal Cancer Surgery
Colorectal cancer (CRC) is the third most common malignancy worldwide, with more than 1.9 million new cases reported annually. Survival among patients with CRC depends on several factors, including disease stage at diagnosis, the…
- Trial name
- ATOCCS (NCT07718919)
- Where
- Italy
- Volunteers
- 6,129 people
- Sponsor
- Academy of Applied Medical and Social Sciences, Poland
Gastric Cancer
Surgical Conversion of Candonilimab (AK104) Plus Paclitaxel, S-1 and Apatinib for Unresectable Advanced G/GEJ Cancer
This is a prospective, single-arm, open-label，single-center, phase II study, aiming to to evaluate the surgical conversion feasibility of AK104 combined with apatinib, paclitaxel and S-1 in unresectable stage IV G/GEJ cancer.
- Trial name
- NCT05853172
- Testing
- AK104, Apatinib, Paclitaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer, Inflammatory Bowel Diseases
Home To Stay: a Randomized Trial Evaluating a Post-discharge Mobile App for Elective Colorectal Surgery
A single center randomized controlled trial to evaluate the effect of a post-discharge mobile health application on 30-day re-admission and patient reported outcomes following elective colorectal surgery
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Utilization, Health Care, Surgery
- Trial name
- NCT04968145
- Testing
- Home To Stay Mobile Health Application
- Where
- Canada
- Volunteers
- 282 people
- Sponsor
- Division of General Surgery , Mt. Sinai Hospital
Esophageal Cancer
Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as pemetrexed disodium and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the…
- Trial name
- NCT00268437
- Testing
- carboplatin, Pemetrexed, conventional surgery
- Where
- 90 sites in United States
- Volunteers
- 27 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Neoplasms, Surgical Stomas
Hybrid-everted Versus Hand-sewn or Stapled Esophagogastrostomy in Prevention of Anastomotic Stricture
The investigators improved the hybrid everted esophagogastrostomy and expected to prevent the incidence of anastomotic stricture.
- Trial name
- NCT01139229
- Testing
- hybrid everted esophagogastric anastomosis, the conventional hand-sewn anastomosis, a stapled anastomosis
- Volunteers
- 144 people
- Sponsor
- Sichuan University
Colon Cancer, Surgery
Efficacy and Safety Study of Complete Mesocolic Excision for Colon Cancer
In 2009, Prof. Hohenberger proposed complete mesocolic excision (CME) as standardized, in which the same principle of TME in rectal cancer has been applied to the colon.
- Trial name
- ESCME (NCT01724775)
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shan Wang
Digestive System Neoplasms, Surgery
Observatory of the Quality of Surgical Procedures for Digestive Cancers
Surgery for digestive cancers is managed according to quality standards, validated by the scientific community. Despite the diffusion of these standards through the benchmarks of good practice, the results of the surgery remain…
- Conditions
- Digestive System Neoplasms, Surgery, Surgery--Complications, Quality of Health Care
- Trial name
- Obchir (NCT03681600)
- Where
- 4 sites in Morocco
- Volunteers
- 1,043 people
- Sponsor
- Moroccan Society of Surgery
Colorectal Cancer
Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery
Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability.
- Trial name
- NCT01938300
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Bundang Hospital
Colo-rectal Cancer
Psychological distREsS hipEc oR pelVic Exenteration
The purpose of this study is to describe type and extent of psychological distress (adverse effects) in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with…
- Trial name
- PRESERVE (NCT04956107)
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 225 people
- Sponsor
- University of Aarhus
Oncologic Surgery, Cancer
Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery
This is a research study to evaluate the effectiveness of 3 different types of routine pain management regimens used during clinically indicated, minimally invasive oncologic (cancer) surgery.
- Conditions
- Oncologic Surgery, Cancer, Cancer Surgery, Hepatic Cancer
- Trial name
- LapTAP (NCT06731998)
- Testing
- Local Anesthesia, Laparoscopic Transversus Abdominis Plane block
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Liver Cancer
Combination Chemotherapy and Interferon Alfa-2b in Treating Patients With Nonmetastatic Liver Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, doxorubicin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00471484
- Testing
- recombinant interferon alfa-2b, doxorubicin hydrochloride, fluorouracil
- Where
- Singapore
- Volunteers
- 54 people
- Sponsor
- National Cancer Centre, Singapore
Inflammatory Bowel Diseases
Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response
Background: The immunologic response to stress is regulated by the cytokines. Anti-Tumor Necrosis Factor-α agents are antibodies directed against a key cytokine in the process angiogenesis and collagen synthesis.
- Trial name
- NCT01974869
- Testing
- Anti-tumor necrosis factor alpha agents
- Where
- 4 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- El-Hussuna, Alaa, M.D.
Pancreatic Cancer
Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00010062
- Testing
- fluorouracil, radiation therapy
- Where
- 30 sites in France, Luxembourg
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Epidemiological Study to Monitor Study Participants With Resected Stage II (High Risk) or Stage III Colorectal Cancer for Circulating Tumor DNA Before, During and After Their Treatment With Adjuvant Chemotherapy
This is a multi-site epidemiological study designed to monitor circulating tumor DNA (ctDNA) status in participants with Stage II (high risk)/III colorectal cancer (CRC) following resection/prior to adjuvant chemotherapy (AdCTx)…
- Trial name
- NCT04813627
- Testing
- Regular blood sample collection for ctDNA assessment
- Where
- 74 sites in United States, Belgium and 2 more
- Volunteers
- 2,079 people
- Sponsor
- BioNTech SE
Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer
Confirming the Accuracy of Endoscopic Marking Using a New Marker, a Novel Luminomarker, in Lesion Marking Before Colorectal Cancer Surgery.
Early-stage lesions are difficult to identify intraoperatively during colorectal cancer surgery. Therefore, preoperative lesion marking using a colonoscopic approach is crucial to confirm the location and extent of resection…
- Conditions
- Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer, Indocyanine Green (ICG)
- Trial name
- Tattooing (NCT07380867)
- Testing
- LuminoMark inj. 0.2mL
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul St. Mary's Hospital
Gastrointestinal Neoplasms
Intervention to Motivate Standing &Walking in Gastrointestinal Cancer Surgical Patients
Observational research has linked physical activity with faster recovery, improved quality of life, and greater survival; however, little is known about the effects of physical activity in pre-operative, peri-operative, or…
- Trial name
- NCT01982994
- Testing
- Education/Daily Planning
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Peritoneal Carcinomatosis
Preoperative Inflammatory Markers Predict Postoperative Complications After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Colorectal Carcinomatosis
A retrospective study of a single-center prospective database of patients who underwent curative CRS-HIPEC for peritoneal carcinomatosis (PC) of colo-rectal cancer (CRC), between September 2012 and July 2023 at Reims…
- Trial name
- NCT06318793
- Where
- France
- Volunteers
- 166 people
- Sponsor
- CHU de Reims
Malnutrition, Cancer
Effect of Immune Formula in Gastrointestinal Cancer Patients Undergoing Cancer Surgery
Malnutrition is a common feature in cancer patients and associated with worse outcomes especially increased risk of postoperative complications in patients undergoing surgery.
- Trial name
- NCT06825221
- Testing
- Oral Nutrition supplement
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Pancreatic Cancer
Gemcitabine Pharmacokinetics After Preoperative Chemoradiation Therapy
The goal of this clinical research study is to learn if gemcitabine given during surgery can enter pancreas cancer cells in patients who have already received chemotherapy and radiation.
- Trial name
- NCT01938716
- Testing
- Gemcitabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
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