Clinical trials: Gastrointestinal and Digestive Disorder
Ulcerative Colitis, Crohn's Disease
Long Term Safety of Vedolizumab (MLN0002) in Patients With Ulcerative Colitis and Crohn's Disease
This was an open-label study to provide an opportunity for participants with Ulcerative Colitis (UC) who previously completed Study C13002 (NCT01177228), and for treatment-naïve participants with UC or Crohn's Disease (CD) to…
- Trial name
- NCT00619489
- Testing
- vedolizumab
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Eosinophilic Esophagitis
San Raffaele EoE Biobank
Eosinophilic Esophagitis (EoE) is a immuno-mediated disease, characterised by a Th-2 food-antigen driven chronic inflammatory response of the esophagus.
- Trial name
- EoEBiobank (NCT05896891)
- Testing
- esophagogastroduodenoscopy (EGD), buccal swab, blood withdrawal
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Disease, Crohn's Disease
The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease
Background: Bacteria and other microorganisms that live in the intestines (the gut microbiome) play an important role in a person s health. The gut microbiome helps to regulate the immune system and control inflammation.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT05652491
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ulcerative Colitis
Carotegrast Methyl in Ulcerative Colitis
Carotegrast methyl, an oral α4-integrin inhibitor, was recently approved in Japan for the treatment of active ulcerative colitis (UC). However, real-world data regarding its efficacy and safety remain scarce.
- Trial name
- CAR in UC (NCT06897150)
- Testing
- Carotegrast methyl
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Takayuki Yamamoto
Rectal Neoplasms, Elasticity Imaging Techniques
Shear Wave Elastography of Rectal Adenomas and Cancer
The diagnosis of rectal lesions is a challenging task, and the accuracy of the primary staging is important preoperatively. A relatively novel technology makes it possible to measure the tissue stiffness during endorectal…
- Trial name
- NCT04409990
- Testing
- Shear Wave Elastography
- Where
- Denmark
- Volunteers
- 164 people
- Sponsor
- Vejle Hospital
Intrahepatic Cholangiocarcinoma, Combined Hepatocellular and Cholangiocarcinoma
Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma
This Phase II, open-label, single-arm study evaluated the anti-cancer activity of derazantinib in subjects with inoperable or advanced intrahepatic cholangiocarcinoma (iCCA) who received at least one prior regimen of systemic…
- Trial name
- FIDES-01 (NCT03230318)
- Testing
- derazantinib
- Where
- 41 sites in United States, Belgium and 9 more
- Volunteers
- 148 people
- Sponsor
- Basilea Pharmaceutica
Colorectal Adenoma, Colorectal Cancer
Endocuff Adenoma Detection Rate Pilot Study
Colorectal cancer is the second leading cause of cancer deaths in the UK(1) . Detection of cancer at an early stage, as well as detection and removal of polyps through gold standard colonoscopy examination decreases mortality…
- Trial name
- NCT01761097
- Testing
- Endocuff attachment
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Assessment of a PERT-free Nutritional Therapeutic Delivery System for Cystic Fibrosis
This is a single center, randomized, double-blind, cross-over trial (with a follow-on single-blind safety evaluation stage), assessing a ready-to-drink nutritional supplement used without PERT ("PERT-free"), nutritional…
- Trial name
- NCT04966897
- Testing
- Standard Nutritional Supplement + PERT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- GlycosBio, Inc.
Hepatocellular Carcinoma, Renal Cell Carcinoma
Genome-wide Association Study to Predict Treatment Response for Molecular Targeted Therapy in Hepatocellular Carcinoma and Renal Cell Carcinoma
All Hepatocellular carcinoma and Renal cell carcinoma patients who receive molecular targeted therapy will be candidates for the study.
- Trial name
- NCT01482520
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Alcohol-Related Disorders, Liver Diseases
Michigan Alcohol Improvement Network- Alcohol Reduction and Treatment Trial
The purpose of the study is to determine if providing participants with alcohol-related liver disease with tailored alcohol use treatment options is feasible and acceptable in order to increase their engagement with treatment and…
- Trial name
- MAIN-ART (NCT04473482)
- Testing
- Michigan Alcohol Improvement Network-Alcohol Reduction and Treatment tool
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Hepatocellular Carcinoma (HCC)
Chidamide + Regorafenib in Hepatocellular Carcinoma (HCC)
This open-label, phase Ib/II, multicenter study evaluated the safety, tolerability, efficacy, and PK of chidamide in combination with regorafenib in patients with HCC.
- Trial name
- NCT05770882
- Testing
- Chidamide, Regorafenib
- Where
- 5 sites in Taiwan
- Volunteers
- 7 people
- Sponsor
- Great Novel Therapeutics Biotech & Medicals Corporation
HCC - Hepatocellular Carcinoma
An Exploratory Clinical Study on Neoadjuvant Treatment of Hepatocellular Carcinoma with QL1706 Combined with Lenvatinib
This is a single-center, single-arm, prospective trial to explore the efficacy and safety of neoadjuvant treatment with Iparomlimab and Tuvonralimab Injection combined with lenvatinib in patients with advanced HCC
- Trial name
- NCT06884982
- Testing
- QL1706 Plus Lenvatinib
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Hepatocellular Carcinoma
A Real-world Study of Camrelizumab Combined With Apatinib Mesylate in Unresectable Hepatocellular Carcinoma
To evaluate the efficacy and safety of camrelizumab combined with apatinib mesylate in the treatment of unresectable hepatocellular carcinoma.
- Trial name
- NCT05409482
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Meng Chao Hepatobiliary Hospital of Fujian Medical University
Postoperative Sore Throat, Bronchoscopy
Dexmedetomidine Nasal Spray and Postoperative Sore Throat After Bronchoscopy
The goal of this observational study is to learn whether dexmedetomidine nasal spray is associated with a lower risk of postoperative sore throat in adult patients who underwent bronchoscopy under general anesthesia.
- Conditions
- Postoperative Sore Throat, Bronchoscopy, Hoarseness, Dysphagia
- Trial name
- NCT07894224
- Testing
- Dexmedetomidine Nasal Spray, standard general anesthesia
- Where
- China
- Volunteers
- 4,400 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
HBV, Primary Liver Cancer
Single-cell RNA Sequencing Resolves the Regulatory Role of HBV on the Hepatocellular Carcinoma Immune Microenvironment
In summary, with the help of single-cell sequencing technology, this study aims to focus on elucidating the influence of HBV-induced hepatocellular carcinoma cell metabolic changes on microenvironment remodeling.
- Trial name
- NCT05677724
- Testing
- HBV DNA Sequencing
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fubing Wang
Chronic Hepatitis c
Management of Patients With Hepatitis C in a Public Health Care Setting: The Punjab Model
Background and Aims: The prevalence of hepatitis C virus infection (HCV) infection in Punjab, India is 3.29%, with an estimated burden of around 650,000 viremic chronic HCV (CHC) patients.
- Trial name
- NCT03488485
- Testing
- Direct Acting Antivirals
- Where
- India
- Volunteers
- 50,000 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Rectovaginal Fistula, Anovaginal Fistula
Feasibility and Safety of Additional Injection of Autologous Platelet-rich Stroma to Surgical Treatment of Rectovaginal Fistulas
Is the addition of platelet-rich stroma (PRS) injection, a form of autologous call therapy, to surgical treatment for rectovaginal fistula feasible and safe? The primary endpoints of this study are feasibility and safety until 12…
- Trial name
- PRS-RVF (NCT06798935)
- Testing
- autologous platelet-rich stroma
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Erasmus Medical Center
Deglutition Disorders, Multiple Sclerosis
Neuromuscular Electrostimulation in Multiple Sclerosis People With Dysphagia
Dysphagia is a disabling, life-threatening symptom that can cause death in Multiple Sclerosis people (pwMS) through aspiration pneumonia.
- Trial name
- NCT05063708
- Testing
- Experimental: traditional dysphagia therapy plus Neuromuscular electrostimulation
- Where
- Italy
- Volunteers
- 136 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Colitis
The goal of this clinical trial is to learn if combined therapy with infliximab and ustekinumab works better than using these drugs alone in adult patients with ulcerative colitis.
- Trial name
- COMBO-UC (NCT06453317)
- Testing
- Infliximab, Ustekinumab
- Where
- Poland
- Volunteers
- 172 people
- Sponsor
- Medical University of Lodz
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