Clinical trials: Gene
Hepatitis B
Safety and Pharmacokinetics Study of Healthy Male Adults When Repeatedly Administered Through Intravenous Injection
The purpose of this study is to evaluate the safety and pharmacokinetics of healthy male adults when subjects are repeatedly administered GC1102 (Hepabig_Gene) through intravenous injection.
- Trial name
- NCT01606163
- Testing
- GC1102, JW normal saline
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Laminopathy, Lamin A/C Gene Mutation
Subanalysis in Patients With CARDIoLAMinopathy Enrolled to REPORT-CCM Registry
Observational, retrospective registry with acute and chronic endpoints
- Conditions
- Laminopathy, Lamin A/C Gene Mutation, Heart Failure
- Trial name
- CARDILAM-CCM (NCT04904393)
- Testing
- Implant of the device for Cardiac Contractility Modulation (CCM) Therapy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Monaldi Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Inhaled Steroids on Gene Expression in the Lungs - 2
The purpose of this study is to assess the effect of inhaled beclomethasone (an inhaled corticosteroid) on the pattern of the lung airway epithelium and alveolar macrophages gene expression of healthy smokers.
- Trial name
- NCT00826748
- Testing
- Beclomethasone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Congenital Heart Disease
Genetics of Congenital Heart Disease
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown.
- Trial name
- NCT01192048
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ovarian Cancer, Breast Cancer
Lynne Cohen Consortium Project: Multi-Center Database/Registry
Goals of this registry: 1.1 To collect and store very limited demographic information (age, birthdate, race and ethnicity), limited cancer risk and breast and ovarian disease history, as well as limited family history of breast…
- Trial name
- NCT00776958
- Testing
- Questionnaire
- Where
- 4 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Acute LHON, Onset Within Three Months
Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months
Efficacy Study of Gene Therapy for The Treatment of Acute Leber's Hereditary Optic Neuropathy (LHON) onset within three months
- Conditions
- Acute LHON, Onset Within Three Months, Onset Between 3 to 6 Months, Onset Between 6 to 12 Months
- Trial name
- LHON (NCT03428178)
- Testing
- rAAV2-ND4
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bin Li
Ligament; Laxity, Recurrent Patellar Dislocation
Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes
The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.
- Trial name
- NCT05763108
- Testing
- genetic test, Beighton joint laxity test
- Where
- 2 sites in Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Li-Fraumeni Syndrome, Hereditary Cancer Syndromes
Biomarker Monitoring in TP53 Mutation Carriers
Purpose This study is an 'N-of-one' observational study focusing on individuals with a hereditary predisposition to cancer due to a genetic mutation in the TP53 gene.
- Conditions
- Li-Fraumeni Syndrome, Hereditary Cancer Syndromes, TP53 Gene Germline Mutation Carrier
- Trial name
- NCT02289326
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Healthy, Asthma
Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma
The purpose of this study is to investigate the cytokine levels in nasal lavage and gene expression in nasal scraping following a single nasal dose of JNJ-43260295 in healthy participants, and in atopic mild to mild-persistent…
- Trial name
- NCT02243189
- Testing
- JNJ-43260295, Nasal Allergen Challenge
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Infectious Disease
Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota
The overall aim of the project is to fill an important knowledge gap on the ecological effects of selected antibiotics. The results will be used to guide treatment decisions for common infections to as much as possible reduce the…
- Trial name
- EPAAC (NCT04084106)
- Testing
- Phenoxymethylpenicillin, Amoxicillin, Amoxicillin-clavulanic acid
- Where
- Sweden
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Breast Cancer, Transcriptomes
Transcriptomes Breast, Ovarian and Leukocyte Hereditary Genes Predisposing to Breast and / or Ovarian Cancer
This is a case-control study of molecular diagnostics. This study requires two steps: The first part of the study will be conducted on a population of 20 women without breast cancer and, or ovarian family (Healthy Volunteers…
- Conditions
- Breast Cancer, Transcriptomes, Molecular Diagnostic, Ovarian Cancer
- Trial name
- CASOHAR (NCT02560818)
- Testing
- collection of a blood sample and breast and ovarian tissue, use of a previous blood collection for patients
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Postmenopause
Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women
This is cross-over, randomized clinical trial, with objective to evaluate the effects of low-dose oral hormone therapy and non-oral hormone therapy on endothelial function markers (fibrinogen, von Willebrand factor, c-reactive…
- Trial name
- NCT01432028
- Testing
- Estradiol and Progesterone, Estradiol and Drospirenone
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Denusa Wiltgen
Microbiome
Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment
This study assesses the effects of a probiotic or postbiotic on gut microbiome during antibiotic treatment.
- Trial name
- POTATO-2 (NCT07594860)
- Testing
- Probiotic, Postbiotic
- Where
- Greece
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
UVB Phototherapy Burn, Insulin-like Growth Factor 1
Gene Expression Changes In Young and Geriatric Skin
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults.
- Conditions
- UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging
- Trial name
- NCT03932162
- Testing
- Insulin-Like Growth Factor 1, No Insulin-Lie Growth Factor 1
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wright State University
Meningomyelocele
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood.
- Trial name
- NCT04027374
- Testing
- Fetal surgery for MMC repair
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Brugada Syndrome, Long QT Syndrome 3
Worm Study: Modifier Genes in Sudden Cardiac Death
Quest for modifier genes associated with ventricular arrhythmias in presence of a cardiac sodium channel gene (SCN5A-delPhe1617) mutation.
- Trial name
- NCT02014961
- Testing
- Dermal biopsy, Gastro-intestinal questionnaire, Whole-exome sequencing
- Where
- Netherlands
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypocalcemia, Hypercalcemia
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome
Parathyroid hormone (PTH) gland calcium sensing receptor (CASR) regulates PTH secretion. CASR is also expressed in nephron thick ascending limb (TAL).
- Trial name
- NCT01021280
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
RAI1 Gene 17P11.2 Deletion+Duplication
Clinical and Molecular Biomarker Studies in RAI1 (Retinoic Acid-Induced 1) -Related Disorders
Currently, there is no clinically available genetic-based treatment for RAI1 (Retinoic Acid-Induced 1) -related disorders other than symptomatic management and there are no established clinical or molecular biomarkers that could…
- Trial name
- NCT06274164
- Testing
- Electroencephalography/Polysomnography (EEG/PSG), Skin Biopsy, Blood draw
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
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