Clinical trials: Gene Expression
Breastfeeding, Breast Milk Expression
The Effect of Hypno-breastfeeding and Solution-oriented Approach
Motivation, which is also necessary for the breastfeeding behavior of mothers in the postpartum period, can affect the success and continuity of breastfeeding.
- Trial name
- NCT05599542
- Testing
- Solution-oriented approach, Hypno-breastfeeding
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Sepsis, SIRS(Systemic Inflammatory Response Syndrome)
Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients
The imbalance between anti- and pro-inflammation often occurs in patients with sepsis. And continuous such imbalance could lead to immunoparalysis, which is characterized by loss of delayed type hypersensitivity, failure of…
- Trial name
- NCT01801839
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gene Expression in Response to Acute Stress
Temporal Genomics Mechanisms Underlying Disease and Aging
Given the salient role of early-life adversity and the resulting biological embedding in disease risk, there is a critical need to understand the mechanisms operating at multiple levels of analysis in order to promote effective…
- Trial name
- NCT03637751
- Testing
- Behavioral, Control condition
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Penn State University
Bladder Cancer
Expression of MCM5 in Urine in Patients With Urothelial Cancers
In patients with non-muscle-invasive bladder cancer, the development and introduction to the clinical practice of an adequately accurate biomarker may allow to limit the indications for performing control cystoscopy.
- Trial name
- NCT03796299
- Testing
- Assessment of expression of MCM5 in the urine (ADX Bladder)
- Where
- Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Multiple Sclerosis
Immune Regulation in Multiple Sclerosis: The Effect of Glatiramer Acetate on MicroRNA Expression in Antigen-Presenting Cells
MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and glatiramer…
- Trial name
- NCT01993004
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Fibromyalgia (FM), Pain
Analysis of Facial Expressions for Pain Recognition in Fibromyalgia: Using Artificial Intelligence and Biomarkers
Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome with characteristics of generalized body pain, low pain threshold, tenderness and stiffness in muscles, tendons and joints.
- Conditions
- Fibromyalgia (FM), Pain, Catastrophizing Pain
- Trial name
- Fibromyalgia (NCT06813352)
- Where
- Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Sleep Quality, Meal Timing
This Trial Examines How Last Meal Composition and Timing Affect Sleep Quality and Circadian Gene Expression Among Medical Residents. Recruitment Not Yet Started; Study Begins Dec 2025 and Ends Dec 2026.
This randomized controlled trial aims to evaluate the effects of last meal composition and timing on sleep quality and circadian gene expression among medical residents in Jordanian hospitals.
- Conditions
- Sleep Quality, Meal Timing, Circadian Rhythm, Medical Residents
- Trial name
- CHRONO-MED (NCT07339592)
- Testing
- High-Carbohydrate Last Meal, High-Protein Last Meal, Balanced Standard Dinner
- Where
- Jordan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Obesity
Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects
Obesity-induced chronic inflammation is a key component of the pathogenesis of insulin resistance. Mounting evidence has demonstrated anti-inflammatory characteristics for vitamin D.
- Trial name
- NCT01752244
- Testing
- Alfacalcidol
- Where
- Iran
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Seaweed Associated Changes in Healthy Subjects
Dietary Seaweed and Early Breast Cancer: A Randomized Trial
Could daily consumption of seaweed help explain lower postmenopausal breast cancer (BC) incidence and mortality rates in Japan? This small proof of principle clinical trial was designed to test the idea that the same amount of…
- Trial name
- NCT01663792
- Testing
- Seaweed
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Healthy Subjects, Heme Oxygenase
Reresveratrol Administered to Healthy Male Subjects
Heme oxygenase 1 (HO-1) serves as a protective gene. The aim of this clinical trial is to evaluate the HO-1 stimulation of resveratrol in healthy humans.
- Trial name
- REVAHS (NCT01768507)
- Testing
- Resveratrol
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Daniel Doberer
Multiple Sclerosis
Expression of PARP-1 in Multiple Sclerosis Patients
This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients. The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021.
- Trial name
- NCT05196425
- Testing
- Blood sampling
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Sepsis, Immunosuppression
Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis
Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit…
- Trial name
- NCT01976884
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Rheumatoid Arthritis
IL-6, IL-12, IL-15 and IL-23 Expression Levels in Rheumatoid Arthritis Patients
Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and articular damage. Continuous medical research has dramatically improved the outcomes for patients with RA.
- Trial name
- NCT06558305
- Testing
- blood sample
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Oxidative Stress, Exercise
Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance
There are conflicting evidences of the effects of dietary supplementation with polyunsaturated fatty acids (PUFAs) on athletic performance.
- Conditions
- Oxidative Stress, Exercise, Training Season, Antioxidant Capabilities
- Trial name
- NCT02177383
- Testing
- Docosahexaenoic acid diet supplementation
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Healthy Young Male Volunteers, Non Athletes
Study of Effects of Low Level Laser Therapy in the Physical Training and the Muscle Responses in Humans.
The hypothesis of this study is that a chronic program of physical strength training, associates to effects of low level laser therapy (LLLT) can, possibly, provide changes in genic expression of muscle and to promote an…
- Conditions
- Healthy Young Male Volunteers, Non Athletes, Free of Metabolic Disease, Joint, Bone and Muscles of Lower Limbs Free of Any Disease
- Trial name
- NCT01113021
- Testing
- Photon stimulation by low level laser therapy
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Pancreatic Cancer
Detection of High Expression Levels of EMT-Transcription Factor mRNAs in Patients With Pancreatic Cancer and Their Diagnostic Potential
The present study is aimed at detecting and measuring mRNA levels of genes involved in epithelial to mesenchymal transition (EMT) in biological samples, i.e.
- Trial name
- NCT04323917
- Testing
- Liquid biopsy
- Where
- Italy
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
HIV-Associated Lipodystrophy Syndrome, Cardiovascular Disease
HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)
This is a prospective, non-randomised, 48 week study of the effect of protease inhibitor (PI) containing and non-PI containing antiretroviral regimens on the expression of adipocyte specific genes, protein levels and cellular…
- Trial name
- NCT00192660
- Testing
- Lamivudine, Stavudine, Didanosine
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
FATTY LIVER, NO MALIGNANCY
Telomere Parameters in Patients With Nonalcoholic Fatty Liver
Telomerase, through its regulatory function on telomere length may play an important role in immune function, cellular replicative life span, and carcinogenesis.
- Conditions
- FATTY LIVER, NO MALIGNANCY, NO DECOMPENSATED ILLNESS
- Trial name
- telomereFL (NCT01694342)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Allergic Asthma, Allergic Rhinitis
The Role of Th9 Cells and Eosinophils Activity in Allergic Airway Diseases
The prevalence of allergic diseases, especially airway allergic diseases, has increased dramatically over the last twenty years all over the world including Lithuania.
- Trial name
- SAIRA (NCT02214303)
- Where
- Lithuania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Vitiligo
Janus Kinase 1 in Vitiligo & Psoriasis
Assessment of the level of JAK1 in both vitiligo and psoriasis patients before and after treatment with NB-UVB which is considered a gold standard therapy for both diseases.
- Trial name
- NCT03762551
- Testing
- skin biopsy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University