Clinical trials: Gene Expression
Hyperoxia
Proteomics for Identification of Hyperoxia-induced Changes in Protein Expression
Aim of the present study is to investigate the influence of hyperoxia on the protein expression using the differential analysis of protein expression in tissues (proteomics).
- Trial name
- NCT02553668
- Testing
- Oxygen (FiO2 1,0), Facemask
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Sleep Deprivation
Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood
Sleep deprivation was found to affect many organs including the immune system and predisposing for various health consequences including diabetes hypertension infections and increase in neoplastic diseases.
- Trial name
- NCT01930279
- Testing
- Blood withdrawal
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Kidney Diseases
Intestinal Phosphate Transporter Expression in CKD Patients
The aim of the present study is to study the expression of the various phosphate transporters in patients with normal or moderately impaired renal function or in patients on dialysis.
- Trial name
- PeTRA (NCT02539680)
- Testing
- endoscopy
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Pharmacokinetics, Drug Interactions
Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2
The purpose of this study is to evaluate the effects of a chronic co-medication of efavirenz on pharmacokinetics and sterol-lowering effects of ezetimibe at steady-state in healthy subjects genotyped for ABCB1, ABCC2, CYP2B6 and…
- Conditions
- Pharmacokinetics, Drug Interactions, Pharmacodynamics, Intestinal Transporter Expression
- Trial name
- NCT00810303
- Testing
- Ezetrol (ezetimibe) multiple dose, Ezetrol (ezetimibe) multiple dose and Sustiva (efavirenz) single dose, Ezetrol (ezetimibe) and Sustiva (efavirenz) multiple dose
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dry Eye Syndrome
CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome
The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.
- Trial name
- NCT00991679
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Autophagy
Expression of LC3-I, LC3-II & Beclin 1 in Vitiligo
The exact mechanism of impairment of autophagy in vitiligo has not yet been determined.
- Trial name
- NCT03371758
- Testing
- skin biopsy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Type 2 Diabetes, Heart Disease
The Effect of Alcohol on ABCA1 Expression and Lipid Metabolism
The purpose of this study is to investigate the effects of red wine on ABCA1 levels
- Trial name
- NCT00558935
- Testing
- Red Wine
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Rheumatoid Arthritis
Feasibility of a Cytokine Expression Profile in Immune Cells as an Orientation Tool in Therapeutic Decisions for Auto-inflammatory and Auto-immune Diseases
This study will assess the feasibility of using cytokine expression profiles in blood samples as a method for evaluating rheumatoid polyarthritis
- Trial name
- IL-MAI (NCT03280797)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cytokine Measurements, Orthodontic Space Closure
Biological Markers Evaluation of Accelerated Tooth Movement
Gingival Crevicular Fluid samples will be collected using periopapers after accelerated tooth movement technique, results will be assessed with biomarkers levels done using ELISA Assays
- Conditions
- Cytokine Measurements, Orthodontic Space Closure, Tooth Movement
- Trial name
- NCT02887547
- Testing
- micro-osteoperforation
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy, Obesity
Sex Differences in Gene Expression in Human Adipose Tissue
This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand: 1.
- Trial name
- NCT00677651
- Testing
- Adipose Biopsy, Blood sample, CT Scan
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Metabolic Syndrome
Effect of Resvida, a Comparison With Calorie Restriction Regimen
The purpose of this study is to compare the effects of the antioxidant "resveratrol" to a diet intervention (Calorie Restriction) to determine how each of them affects the following: gene expression profile, cholesterol (lipids)…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes, Aging
- Trial name
- Resvida (NCT00823381)
- Testing
- resveratrol, Calorie Restriction
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Migraine
The Link Between Human Cytomegalovirus Gene Expression and Glutamate Level in Migraine;Relation to Vitamin D Deficiency
1. To correlate serum 25(OH)-vitamin D level with duration, frequency, and severity of migraine headache attacks 2. To evaluate the relationship between the serum level of vitamin D and other indices in patients with migraine. 3.
- Trial name
- NCT06304948
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy, Infertility
The Expression of IL-15 and Its Receptor in Decidua
Human decidual tissue appears to play an important role not only in nurturing the implanted embryos, but also in preventing its rejection by the maternal immune system.
- Trial name
- NCT00173758
- Testing
- co-culture of embryos and endometrial cells
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.
2.1 Study the role of NLRP3 inflammasome in COVID-19 patients. 2.2 Study the gene expression of NLRP3 and IL-1β in blood samples of COVID-19 patients and compare to apparently healthy subjects.
- Trial name
- NCT06080750
- Testing
- Quantitative Real Time Polymerase chain reaction (qRT-PCR), ELISA and colorimeter
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility
Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women
The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.
- Trial name
- NCT02219425
- Testing
- endometrial biopsy
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Myocardial Infarction, Acute
Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction
Cardiac-enriched micro-RNAs (miRNAs), micro RNA 208b and 133a(MiR-208b, MiR-133a)) corresponds to the health and disorders of the cardiovascular system. An intron of the cardiac myosin heavy chain gene MYH7 encodes miR-208b.
- Trial name
- NCT05692752
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Islamia University of Bahawalpur
Atherosclerosis, Cardiovascular Diseases
Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk
Cardiovascular disease (CVD), including heart disease, heart attack, high blood pressure, and stroke, is most commonly caused by atherosclerosis, or a hardening of the arteries.
- Trial name
- NCT00613158
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sepsis
TRIM25 in Septic Patients
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure.
- Trial name
- NCT07320638
- Testing
- Gene and Inflammatory Marker Analysis in Sepsis
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Schizophrenia
Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome
Background: The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in schizophrenia and the 22q11.2 deletion syndrome, and thus, reveal a distinction between the two…
- Trial name
- FaSchi22 (NCT02634671)
- Testing
- schizophrenia, the 22q11 deletion syndrome, control group
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Ovarian Hyperstimulation Syndrome
Endometrial Receptivity After GnRH Agonist Triggering
Conventional luteal phase support after human chorionic gonadotrophin (hCG) triggering in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) provides adequate pregnancy rates and live birth rates…
- Trial name
- ERAMAD (NCT01500863)
- Testing
- hCG, triptorelin, Triptorelin, estradiol valerate, micronized vaginal progesterone
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- IVI Madrid