Clinical trials: Gene Expression
Heat Intolerance, Genotypic Variations
Heat Intolerance- A Lesson From Global Genomic Response in Lymphocytes
Heat Intolerance (HI) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups.
- Conditions
- Heat Intolerance, Genotypic Variations, Gene Expression, Genomic Markers for Predisposition of Heat Intolerance
- Trial name
- NCT00918359
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Asthma Patients
ICS+LABA Vs. ICS+LABA+Omalizumab: Impact on Asthma Control and Gene Expression
Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction, leading to wheezing, breathlessness, chest tightness, and coughing.
- Trial name
- NCT06869382
- Testing
- Foster BDP/Formoterol, Omalizimab
- Where
- Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Symptomatic Periapical Periodontitis
Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial
the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.
- Trial name
- NCT04324398
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
p53 Expression
To Evaluate and Compare p53 Epidermal Expression in Healthy Volunteers 3 Months After Treatment With a 2,940-nm Fractional Ablative Erbium Laser and Topical DNA Repair Enzymes
The p53 gene is located on the short arm of chromosome 17 and serves as a tumor suppressor gene. Alteration in p53 is an early event in skin cancer development.
- Trial name
- NCT04277949
- Testing
- Erbium:YAG, UV endonuclease from Micrococcus luteus
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Moy-Fincher-Chipps Facial Plastics and Dermatology
Relapsed/Refractory Small Cell Lung Cancer
This Study is an Open-lable, Early Study to Evaluate the Safety, Feasibility, Cytokinetics, and Preliminary Efficacy of GC511B in DLL3+ Relapsed/Refractory Small Cell Lung Cancer.
This is a First-in-Human, open-label, early dose-escalation clinical study to evaluate the safety and preliminary efficacy of GC511B CAR T cell injection in Adult with DLL3+ r/r SCLC trial participants.
- Trial name
- NCT07249879
- Testing
- GC511B CAR-T Cell Injection
- Where
- 2 sites in China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Human Development, Genetic Disease
Sanger Human Cell Atlasing Project
"Cell Atlasing" refers to a novel strategy to characterise cells in tissues at the molecular level in a quantitative manner. The international Human Cell Atlas consortium brings together a community of biologists, clinicians…
- Trial name
- HCA (NCT06497673)
- Testing
- sample collection
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The Wellcome Sanger Institute
Tuberculosis
Study in Healthy Adults to Evaluate Gene Activation After Vaccination With GlaxoSmithKline (GSK) Biologicals' Candidate Tuberculosis (TB) Vaccine GSK 692342
The purpose of this study is to assess the safety and immunogenicity of two doses of the TB vaccine administered according to a 0, 1 month schedule.
- Trial name
- NCT01669096
- Testing
- GSK Biologicals' investigational TB vaccine GSK 692342
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Psoriasis, Periodontal Diseases
Interleukin- 17 (IL-17), Bcl-3, and NF-kappa-B Inhibitor Zeta (IκBζ) Expression Levels in the Psoriasis Patients
This study aimed to compare the levels of IL-17 (interleukin- 17), Bcl-3 (B-cell lymphoma 3-encoded protein), and IκBζ (NF-kappa-B inhibitor zeta) in the gingival crevicular fluid of psoriatic and healthy individuals and the…
- Trial name
- NCT06408454
- Testing
- Gingival crevicular fluid collection, periodontal test
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Healthy Volunteer
Endophenotype Characterization of a Family Psychiatric Disorder
Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.
- Trial name
- EnBiGen (NCT02843997)
- Testing
- Endophenotype and sequencing
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Pulpitis
MMP-9 Expression in Permanent Mature Teeth With Symptomatic Pulpitis
Matrix metallopeptidase-9 (MMP-9) expression was compared in healthy and inflamed pulp and the outcome of coronal pulpotomy in teeth with symptomatic pulpitis was assessed.
- Trial name
- NCT03807674
- Testing
- Coronal pulpotomy
- Where
- Lithuania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eglė Gvazdaitytė
Type 2 Diabetes
Gene Expression Profiling and Bioinformatic Analysis Identifying Genes and Biochemical Pathways in Type 2 Diabetes
Type 2 diabetes is a disorder of the metabolic system that greatly affects individual health and imposes significant cost for society on health care.
- Trial name
- NCT00143013
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
HIV Infections
Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
The P-glycoprotein (P-gp) is a membranous transporter that modulates the intracellular concentrations of many drugs and plays thus a major role in the efficacy of the therapeutics that act within the lymphocytes, such as…
- Trial name
- Onto-Pgp (NCT00702013)
- Where
- France
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Volunteer, Prostate CA
Ultralow Dose PET Imaging for PSMA Expression
The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for prostate cancer detection and monitoring.
- Trial name
- NCT06904313
- Testing
- Piflufolastat F18
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery
Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE
To evaluate the diagnostic efficiency of the neural network in predicting complications of Small Incision Lenticule Extraction in a multi-center cross-sectional study.
- Conditions
- Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery, Intraoperative Complications, Postoperative Outcomes
- Trial name
- NCT06204926
- Testing
- AI diagnostic algorithm
- Where
- China
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Inflammatory Bowel Diseases
Mucosal Gene Expression Defects in IBD
This study investigated the mucosal gene expression defects associated with active Crohn's disease (CD)and ulcerative colitis (UC), and studied the effect of infliximab induced downregulation of inflammation and mucosal healing…
- Trial name
- NCT00639821
- Where
- Belgium
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Acute Myeloid Leukemia
Clinical Characters and Outcome of Acute Myeloid Leukemia Patients on Correlation to CD200 and CD56 Expression
estimation of the clinical characters and out come of adult acute myeloid leukemia patients correlation of the estimated clinical characters and outcome to the expression of CD200
- Trial name
- NCT05512104
- Testing
- bone marrow aspirate and biopsy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Athletes
CD71 in Dried Blood Spots in Healthy Males
Understand the effect of recombinant EPO (rEPO) boosting and microdosing on the hematological module of the Athlete Biological Passport (ABP) Measure the change in CD71 longitudinally in subjects from both cohorts Assess whether…
- Trial name
- NCT04073849
- Testing
- EPOGEN® (epoetin alfa), Normal Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sports Medicine Research and Testing Laboratory
Osteopathic Manipulation, Low Back Pain
The Effects of OMT on the Expression Patterns of Immune Cell Biomarkers
This study intends to understand the effects of osteopathic manipulative treatment (OMT) on the expression patterns of 60 immune cell biomarkers in the peripheral blood mononuclear cells (PBMC) of each participant, before and…
- Conditions
- Osteopathic Manipulation, Low Back Pain, Biomarkers
- Trial name
- NCT03250312
- Testing
- The Osteopathic Manipulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- A.T. Still University of Health Sciences
Obesity, Childhood
GI Tract Biomarkers in Infants With Different Diets
Childhood obesity is increasing with more than one-third of adolescents currently overweight and one in five with obesity. The lifelong incidence of obesity-related morbidities is also increasing with childhood obesity.
- Trial name
- NCT03751137
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic