Clinical trials: Gene Expression
Post-operative Pain
Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.
To compare the effect of cryotherapy versus ketorolac tromethamine irrigating solutions used as a final flush in single visit endodontic treatment in mandibular molars, with symptomatic irreversible pulpitis and apical…
- Trial name
- NCT04733326
- Testing
- Ketorolac Tromethamine, Cryotherapy, Saline
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Generalized Aggressive Periodontitis
Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis
In this study, the investigators evaluated molecular biomarkers which play a role in the development of generalized aggressive periodontitis (GAgP) using gingival tissue samples through omics-based whole-genome transcriptomic…
- Trial name
- NCT02327533
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Healthy Young Male Volunteers, Non Athletes
Study of Effects of Low Level Laser Therapy in the Physical Training and the Muscle Responses in Humans.
The hypothesis of this study is that a chronic program of physical strength training, associates to effects of low level laser therapy (LLLT) can, possibly, provide changes in genic expression of muscle and to promote an…
- Conditions
- Healthy Young Male Volunteers, Non Athletes, Free of Metabolic Disease, Joint, Bone and Muscles of Lower Limbs Free of Any Disease
- Trial name
- NCT01113021
- Testing
- Photon stimulation by low level laser therapy
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis
A Study to Evaluate the Effect of Bimekizumab on Gene Expression Biomarkers in Study Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the effect of bimekizumab on gene expression biomarkers at Week 48 in a subset of study participants with moderate to severe plaque psoriasis (PSO) and moderate to severe plaque PSO with…
- Trial name
- BE UNIQUE (NCT06506916)
- Testing
- bimekizumab
- Where
- 14 sites in United States, Germany and 1 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UCB Biopharma SRL
Gastroesophageal Reflux Disease, Obesity
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
The investigators long-term goal is to understand how PPIs influence energy balance in both obese and normal-weight individuals.
- Trial name
- NCT02457104
- Testing
- Colonoscopy, Weight and diet questionnaire
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-segmental Vitiligo
ASSESSMENT OF TRISTETRAPROLIN EXPRESSION IN LESIONAL SKIN OF PATIENTS WITH NON SEGMENTAL VITILIGO
Vitiligo is characterized by the selective loss of melanocytes, which in turn leads to totally amelanotic, non-scaly, chalky-white macule with distinct margins Vitiligo is the most common depigmenting skin disorder, with an…
- Trial name
- NCT05990309
- Testing
- skin biopsy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Endotoxemia
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
The purpose of this study is to determine the effects of HMG-CoA reductase inhibitor pretreatment on inflammation and coagulation activation in human endotoxemia.
- Trial name
- NCT00309374
- Testing
- LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hepatocellular Carcinoma
Genetic Studies in Liver Cancer Patients
Hepatocellular carcinoma (HCC) is one the most common malignancies in the world, especially in sub-Saharan Africa and Southeast Asia. Since 1984, it has been the leading cause of cancer death in Taiwan.
- Trial name
- NCT00172640
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
PET/CT, hLAG-3
68Ga-DOTA-hLAG-3 PET Imaging of LAG-3 Expression in Cancers
To evaluate the potential usefulness of 68Ga-DOTA-hLAG-3 positron emission tomography/computed tomography (PET/CT) for the evaluation of LAG-3 expression in primary and/or metastatic tumors, compared with histopathological…
- Conditions
- PET/CT, hLAG-3, TUMOR
- Trial name
- NCT05346276
- Testing
- 68Ga-DOTA-hLAG-3 PET/CT
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xiamen University
Hyperlipidemias, Xerosis
Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation
Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which…
- Conditions
- Hyperlipidemias, Xerosis, Depression, Liver Diseases
- Trial name
- NCT04245319
- Testing
- Acitretin, Narrow band ultraviolet B
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ulcerative Colitis, Crohn's Disease
Study on Cannabinoid Receptor Expression in Gastrointestinal Diseases
The purpose of the study is to investigate phospholipid ligands and their receptors in inflammatory bowel diseases and colon cancer.
- Conditions
- Ulcerative Colitis, Crohn's Disease, Colon Cancer
- Trial name
- NCT02735941
- Where
- Austria
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetic Nephropathy
The Expression of circANKRD36 as a New Biomarker of Diabetic Nephropathy
1. To evaluate expression levels of circANKRD36 in the development and progression of DN. 2. To investigate correlation between expression levels of circANKRD36 and stages of DN. 3.
- Trial name
- NCT05061459
- Testing
- circANKRD36 as a new biomarker
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breastfeeding, Breast Milk Expression
Mothers' Breast Milk Expression Experiences, Infant Feeding Attitudes and Perceived Social Support Levels
Background: Expressing breast milk in cases where breastfeeding is interrupted is important for infants to be fed breast milk however, many factors can affect mothers' breastfeeding experience, such as feeding attitudes and the…
- Conditions
- Breastfeeding, Breast Milk Expression, Feeding Behavior, Support, Family
- Trial name
- NCT05992753
- Testing
- Questionnaire application
- Where
- Turkey (Türkiye)
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Halic University
Breast Milk Expression, Breast Feeding, Exclusive
The Management of Perceived Breastmilk Insufficiency
A randomized control trial was made to determine the effectiveness of structured education and follow-up in the management of perceived milk insufficiency among breastfeeding mothers.
- Trial name
- NCT04729166
- Testing
- Structured education and follow-up
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Alzheimer's Disease
The Study of microRNA 107 (miRNA 107) and Beta-amyloid Precursor Protein-cleaving Enzyme 1 (BACE1) Messenger Ribonucleic Acid (mRNA) Gene Expression in Cerebrospinal Fluid and Peripheral Blood of Alzheimer's Disease
The miRNA 107 gene is increasingly appreciated to serve key functions in humans. The miRNA regulate gene expression involved in cell division, metabolism, stress response, and angiogenesis in vertebrate species.
- Trial name
- NCT01819545
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Breast Feeding, Breast Milk Expression
A Cohort Study on Milk Composition, Health Outcomes, and Feeding Practices of Chinese Mothers and Infants
This is a cohort study to understand the changes of breastmilk composition in the first six months after birth of Chinese infants.
- Trial name
- Phoenix (NCT05235412)
- Testing
- Not applicable: Observational study without any interventions.
- Where
- China
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Disorder of Consciousness, Consciousness, Loss of
SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models.
- Conditions
- Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury
- Trial name
- NCT06083441
- Testing
- SeeMe, Coma Recovery Scale-Revised (CRS-R)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Vitiligo
Thymic Stromal Lymphopoietin (TSLP) in Vitiligo
study \& verify the hypothesis of the involvement of TSLP in the pathogenesis of vitiligo in comparison to their levels in the healthy control persons.
- Trial name
- NCT03367273
- Testing
- skin biopsy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ankylosing Spondylitis, AS
Expression of Tim-3 on Neutrophils in Ankylosing Spondylitis
1. To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers. 2.
- Conditions
- Ankylosing Spondylitis, AS, Tim3
- Trial name
- NCT07383805
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Assiut University