Clinical trials: Gene Expression
Rheumatoid Arthritis
IL-6, IL-12, IL-15 and IL-23 Expression Levels in Rheumatoid Arthritis Patients
Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and articular damage. Continuous medical research has dramatically improved the outcomes for patients with RA.
- Trial name
- NCT06558305
- Testing
- blood sample
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Smiling, Botulinum Toxins, Type A
Higher Doses of Botulinum Toxin in the Treatment of Gummy Smile
Botulinum type A (BTX-A) is an easy and efficacious treatment for gingival smile (GS). However, the necessary for higher-doses among patients are controversial.
- Trial name
- NCT05127018
- Testing
- injection of Botulinum type A
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking University
Obesity, Pregnancy
Maternal Obesity, Breast Milk Composition, and Infant Growth
Today the majority of pregnant women in the United States are either overweight or obese at conception with their offspring having greater adiposity at birth, a 2-fold greater risk of later obesity, and neonatal insulin…
- Conditions
- Obesity, Pregnancy, Breastmilk Collection, Infant Overnutrition
- Trial name
- (MILK) (NCT03301753)
- Where
- 2 sites in United States
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Nurse's Role, Anger
Impact of a Mindfulness-Oriented Psychoeducational Program on the Mindfulness, Anger and Interpersonal Relationship Styles
Aim: This study aimed to investigate the impact of a mindfulness-oriented psychoeducational program on nursing students' levels of mindfulness, anger, anger expression, and interpersonal relationship styles.
- Conditions
- Nurse's Role, Anger, Interpersonal Relations
- Trial name
- NCT06901583
- Testing
- Mindfulness-oriented psycho-education
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Allergic Asthma, Allergic Rhinitis
The Role of Th9 Cells and Eosinophils Activity in Allergic Airway Diseases
The prevalence of allergic diseases, especially airway allergic diseases, has increased dramatically over the last twenty years all over the world including Lithuania.
- Trial name
- SAIRA (NCT02214303)
- Where
- Lithuania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Metabolic Syndrome X
Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health
Fish oil supplements (which are rich in omega-3 fatty acids) have been shown to provide cardiometabolic benefits to individuals of all ages.
- Trial name
- FOHS (NCT02042274)
- Testing
- Fish oil supplement
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Gastric Cancer
Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer（RC48-C018）
This trial is a multi-center, open, single-arm, superior phase II clinical study.
- Trial name
- NCT05113459
- Testing
- Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guoxin Li
Acute Kidney Injury
Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery
The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene…
- Trial name
- NCT05871203
- Testing
- Gene sequencing
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatitis C
Expression of Inflammasomes in HCV Patients
Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma.
- Trial name
- Inflammasome (NCT04244383)
- Testing
- interleukin IL-1beta and interleukin IL-18
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chest Pain, Coronary Artery Disease
A Registry to Evaluate Patterns of Care Associated With the Use of Corus CAD (or ASGES) in Primary Care Settings
The PRESET Registry--A Registry to Evaluate Patterns of Care Associated With the Use of Corus CAD (Age/Sex/Gene Expression score - ASGES) in Real World Clinical Care Settings (PRESET)--was designed as an observational…
- Conditions
- Chest Pain, Coronary Artery Disease, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- PRESET (NCT01677156)
- Testing
- CORUS CAD (ASGES)
- Where
- 13 sites in United States
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- CardioDx
Chronic Periodontitis
Gene Expression Profiles in Chronic Periodontitis
Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis.
- Trial name
- NCT02467283
- Testing
- Genom-based whole-genome transcriptomic
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Low Responder
Oxidative Stress-related Gene Expression in Cumulus Cells Among Low Responders
In Vitro Fertilization is considered one of effective treatment for infertile couple. However, some women do not have adequate response to controlled ovarian hyperstimulation, resulting in low response which defined as less than…
- Trial name
- NCT03155438
- Testing
- Oxidative stress-related gene expression (RNA expression), oocyte competence biomarkers
- Where
- Thailand
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Smiling, Botulinum Toxins, Type A
Effects of Dose and Injection Site for Gummy Smile Treatment With Botulinum Type A
Botulinum type A (BTX-A) is an easy and efficacious treatment for gingival smile (GS). However, its dosage and injection sites effect among patients are controversial.The objective was to compare the reduction of gingival…
- Trial name
- NCT04820543
- Testing
- injection of Botulinum type A
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Peking University
Obesity
Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects
Obesity-induced chronic inflammation is a key component of the pathogenesis of insulin resistance. Mounting evidence has demonstrated anti-inflammatory characteristics for vitamin D.
- Trial name
- NCT01752244
- Testing
- Alfacalcidol
- Where
- Iran
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pancreatic Cancer
Detection of High Expression Levels of EMT-Transcription Factor mRNAs in Patients With Pancreatic Cancer and Their Diagnostic Potential
The present study is aimed at detecting and measuring mRNA levels of genes involved in epithelial to mesenchymal transition (EMT) in biological samples, i.e.
- Trial name
- NCT04323917
- Testing
- Liquid biopsy
- Where
- Italy
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Endothelial Dysfunction, Disorder of Smooth Muscle
The Effect of a Diabetic- and a Kidney-like Environment on Gene and Protein Expression in Cultured EC and SMC
This research is NOT part of an interventional trial, however the investigators use umbilical cord after birth for isolating endothelial and smooth muscle cells for academic research.
- Trial name
- NCT01423279
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Aging
Circulating SIRT6 Expression, Effect on Aging Quality
This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging.
- Trial name
- Sirt6 (NCT01567176)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aggressive Periodontitis
Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP
The aim of this study is to estimate genetic impact of MCP-1 -2518 and its receptor CCR2 -190 polymorphisms on AgP patients among Turkish individuals and whether MCP-1 genotype effects mRNA levels of Peripheral Blood Mononuclear…
- Trial name
- NCT02817568
- Testing
- Drawing Blood
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Parkinson
The Effect of Deep Brain Stimulation on Facial Expressions.
Whether Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS), a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), affects on facial expressions is unclear.
- Trial name
- STN-DBS (NCT03558568)
- Testing
- Deep Brain Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Somatic Symptom Disorder
Internet-based Emotional Awareness and Expression Therapy for Somatic Symptom Disorder
The main purpose of the study is to conduct an initial feasibility evaluation of the new Internet-based EAET treatment manual. We will include 50 patients with somatic symptom disorder to take part of the treatment for nine weeks…
- Trial name
- MBS1 (NCT04122846)
- Testing
- Emotional Awareness and Expression Therapy
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet