Clinical trials: Gene Expression
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Vitamin D Deficiency, Breast Milk Collection
Vitamin D Sulfates in Breastmilk
Infants The purpose of this study is to measure breastmilk's vitamin D sulfate nutritional value in infant's saliva and digesta (gut).
- Trial name
- NCT06203041
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Carcinoma, Renal Cell
microRNA Expression in Renal Cell Carcinoma
In this study, renal cell carcinoma (RCC) related miRNA and the target genes of related miRNA will be examined in order to investigate the role of miRNA in the formation of RCC and look for the biomarker of RCC.
- Trial name
- NCT00743054
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility, Female, ENDOMETRIAL RECEPTIVITY
Impact of Different Doses and Routes of Exogenous Progesterone Administration on Endometrial Receptivity Parameters
After so many years conducting artificial endometrial preparation cycles for embryo transfer, there is no clear indication about which is the optimal dose of exogenous progesterone in this scenario to optimize the outcome.
- Trial name
- PROGENDO (NCT04499131)
- Testing
- Progesterone, Artificial Cycle (no intervention)
- Where
- Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Healthy
Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA
The goal of this clinical trial is to learn whether a dietary supplement can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07127445
- Testing
- OEA supplement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nicole Stevens, PhD
Adenomyosis
Norwegian Adenomyosis Study I
Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population.
- Trial name
- NAPPED I (NCT02201719)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Smiling
Botulinum Toxin in the Treatment of Gingival Smile
Objective: to evaluate the effect of two gingival smile treatment techniques using botulinum toxin. Materials and methods: The randomized, double-blind clinical trial (patient and examiner) will be conducted by two trained and…
- Trial name
- NCT03812965
- Testing
- Botulinum toxin type A
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Ibirapuera
Systemic Lupus Erythematosus
Expression of CXCR4 in Patients With Systemic Lupus Erythematosus
The objective of this study is to estimate the possible role of CD184 in the pathogenesis of SLE; comparing its level among SLE cases to healthy controls.
- Trial name
- NCT04799730
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
Immunohistochemical Expression of EGFR in the Patients Having Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the top 10 most common malignancies worldwide. Oral squamous cell carcinoma forms a major health problem in many countries.
- Trial name
- EGFR (NCT06606301)
- Testing
- BioSB EGFR antibody
- Where
- Pakistan
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital, Pakistan
Gastrointestinal Disorders
Change in Permeability of the Small Intestine After Treatment With Gluten
The overall hypothesis of this research study is that gluten intake alters intestinal barrier function in patients with Irritable Bowel Syndrome (IBS) diarrhea who also exhibit non-celiac gluten sensitivity (NCGS).
- Trial name
- NCT02098057
- Testing
- Gluten Healthy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
Obstructive Sleep Apnea and Genes Expression
Obstructive sleep apnea is a multi-component disease. This study will test the hypotheses that hypoxia per se modulates gene expression in animal model of sleep apnea and these results may be translated with alterations that…
- Trial name
- HIP (NCT01392339)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Influenza, Pregnancy
"COhort Study on A/H1N1 FLU During PREGnancy"
The purpose of this study is to measure the incidence of A/H1N1 Influenza infection in the mother and her child and to identify the determinants in pregnant women during pandemic period in three public maternities in Paris…
- Trial name
- COFLUPREG (NCT01192737)
- Where
- 3 sites in France
- Volunteers
- 919 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Myasthenia Gravis
Interleukin and Autoantibodies in Myasthenia Gravis.
Myasthenia gravis is a B-cell-mediated autoimmune disorders causing muscle weakness due to defective synaptic transmission at the neuromuscular junction caused by autoantibodies to acetylcholine receptors in (∼85%), muscle…
- Trial name
- NCT05301153
- Testing
- real time PCR , ELISA
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gene Abnormality
Endometrial Heparin-binding Epidermal Growth Factor Expression
Women with PCOS comprise a majority of fertility clinic attendees. Unfortunately, a high failure rate following fertility treatment was observed especially in obese women due to implantation failure.
- Trial name
- NCT04175002
- Testing
- utrogestan
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Alveolar Soft Part Sarcoma, Sarcoma
Collection of Alveolar Soft Part Sarcoma and Blood Specimens for Research
Background: Alveolar soft part sarcoma (ASPS) is a rare tumor. ASPS is resistant to chemotherapy and radiation. ASPS is characterized by slow growth.
- Trial name
- NCT00340353
- Where
- United States
- Volunteers
- 99,999 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Melanoma
Early Diagnosis of Melanoma Using Expression Profiling and Non-Invasive Sampling of Skin Cells
This study is divided into distinct sample collection and analysis phases. In the sample collection phase investigators will tape strip lesions that are designated for biopsy because they are suspected for melanoma.
- Trial name
- DermTech (NCT00482105)
- Testing
- EGIR Tape
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Asthma
Vitamin A, Its Receptors and Asthma
We wish to understand the association of Vitamin A serum levels and Vitamin A receptor number and responsiveness in asthmatics. We believe that Vitamin A receptors may be less prevalent in asthmatics and their responsiveness…
- Trial name
- NCT00628329
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas
Ankylosing Spondylitis, AS
Expression of Tim-3 on Neutrophils in Ankylosing Spondylitis
1. To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers. 2.
- Conditions
- Ankylosing Spondylitis, AS, Tim3
- Trial name
- NCT07383805
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training
Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, low-level laser therapy has been used to improve muscle performance in experimental models and human researches.
- Trial name
- NCT01784432
- Testing
- Low-level laser therapy and training, Training
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Healthy Adult
The FACIAL Study Pilot
Facial recognition is a non-invasive method for analysing facial characteristics and changes in facial expressions. There is evidence to suggest there may be a link between physiological health and facial expression patterns.
- Trial name
- NCT07011407
- Testing
- Maximal Exercise Test
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lancaster University