Clinical trials: Gene Expression
Autism Spectrum Disorder
Evaluation of Social ABCs With Attention Training Intervention for Toddlers With Suspected Autism
The Social ABCs is an evidence-based, developmentally informed, caregiver-mediated behavioural intervention for toddlers with suspected or confirmed Autism Spectrum Disorder (ASD).
- Trial name
- NCT03215394
- Testing
- Attention Training Program, Social ABCs, Treatment As Usual
- Where
- 4 sites in Canada, United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Parkinson's Disease
Facial Expression Recognition and Mirror Neurons in Parkinson's Disease
After few years of evolution, patients with Parkinson's disease may develop apathy, with different degrees of severity. Apathy is characterized by a loss of interest for the others and for activities.
- Trial name
- NCT01315405
- Testing
- Emotional facial expression recognition tests
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Omega-3 Supplement and Health Markers
The goal of this clinical trial is to learn whether fish oil-based supplements can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT06492694
- Testing
- Fish oil + wild orange essential oil supplement, Fish oil supplement
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Obesity, Prader-Willi Syndrome
Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome
The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity.
- Trial name
- NCT00800852
- Volunteers
- healthy volunteers welcome
- Sponsor
- Samsung Medical Center
SCHIZOPHRENIA 1 (Disorder)
ACT-Based Psychoeducation for Caregivers of Patients With Schizophrenia
This randomized controlled trial aims to examine the effects of an Acceptance and Commitment Therapy (ACT)-based psychoeducation program on expressed emotion, perceived family burden, and psychological flexibility among…
- Trial name
- NCT07656558
- Testing
- Acceptance and Commitment Therapy (ACT)-Based Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Kidney Transplantation
Is T-lymphocyte Calcineurin Phosphatase Up-regulated by Treatment With Tacrolimus?
The purpose of this study is to determine whether calcineurin phosphatase in the T-lymphocytes is up-regulated after long-term treatment with tacrolimus, a calcineurin inhibitor.
- Trial name
- NCT00999362
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Bladder Cancer
Detecting CREPT in Urine for Bladder Cancer Diagnosis and Monitoring
This study will, for the first time, establish a non-invasive diagnostic model for bladder cancer based on CREPT expression levels in exfoliated urothelial cells using a multicenter cohort, and validate its value in the…
- Trial name
- NCT07514897
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Autistic Disorder, Autism Spectrum Disorder
Autonomic Modulation and Facial Expression in Autism Spectrum Disorder
Background: the autism spectrum disorders (ASD) can be related with abnormalities in cortical structures and cause behavior imbalances. In addition, as soon as the diagnosis is done, the better will be the prognosis.
- Trial name
- NCT02997566
- Testing
- Autonomic evaluation
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Oxidative Stress, Exercise
Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance
There are conflicting evidences of the effects of dietary supplementation with polyunsaturated fatty acids (PUFAs) on athletic performance.
- Conditions
- Oxidative Stress, Exercise, Training Season, Antioxidant Capabilities
- Trial name
- NCT02177383
- Testing
- Docosahexaenoic acid diet supplementation
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Knee Osteoarthritis
Analysis of Protein Expression in Serum of KOA Subjects
In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee…
- Trial name
- NCT06553313
- Testing
- Micro-Western Array
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
HIV Infections
Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
The P-glycoprotein (P-gp) is a membranous transporter that modulates the intracellular concentrations of many drugs and plays thus a major role in the efficacy of the therapeutics that act within the lymphocytes, such as…
- Trial name
- Onto-Pgp (NCT00702013)
- Where
- France
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pain, Gene Expression
Bone Marrow Aspiration Pain Study
Background: Many people feel pain during and after bone marrow aspiration (collection). Studies suggest that pain may be related to different kinds of inflammation, or the presence of nitric oxide (a normally occurring gas) in…
- Conditions
- Acute Pain, Gene Expression, Nitric Oxide
- Trial name
- NCT01524523
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Drug Addiction
Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents
Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old.
- Trial name
- NCT05958641
- Testing
- Questionnaires
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Diabetic Foot Ulcer
Low Level Laser Therapy and Expression of VEGF, NO, VEGFR-2, HIF-1α in Diabetic Foot Ulcers
The purpose of this study is to examine the changes of factors including Vascular Endothelial Growth Factor(VEGF), VEGFReceptor-2, Nitric Oxide and hypoxia-inducible factor-1α (HIF-1α), measurements of oxygen saturation in…
- Trial name
- NCT02452086
- Testing
- Low Level Laser(Ga-As)
- Where
- Iran
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tarbiat Modarres University
Caries,Dental, Dental Caries
The Impact of Sage Extract on GTS B and D Gene Expression in S. Mutans
Glucosyltransferases (Gtfs) play a crucial role in the pathogenesis of dental caries caused by Streptococcus mutans. Gtfs is recognized as an attractive target for effective therapeutic interventions aimed at inhibiting…
- Conditions
- Caries,Dental, Dental Caries, Dental Diseases
- Trial name
- NCT06703554
- Testing
- Sage Oil Mouthwash, Chlorohexidine Mouthwash
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Melanoma
MicroRNA Expression and Function in Cutaneous Malignant Melanoma
Spectrophotometric intracutaneous analysis (SIAscopy) is a new technique for imaging pigmented skin lesions and for diagnosing melanoma and non-melanoma skin cancer.
- Trial name
- NCT00536029
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Nasal LPS Challenge in Healthy Volunteers
The purpose of this study is to develop a nasal challenge model that causes a mild degree of inflammation, without causing any pain or symptoms, but that allows us to measure a variety of proteins in nasal secretions which causes…
- Trial name
- NCT02284074
- Testing
- Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sensitive Skin
TRPV Expression in Subjects With Sensitive Skin
Sensitive skin syndrome is defined as the presence of burning, itching or any other unpleasant sensation on the skin, due to physical, chemical or psychological factors.
- Trial name
- NCT01871883
- Testing
- Skin biopsy, Oral mucosa specimen
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Virtual Reality, Breast Milk Expression
Breast Milk Expression With Virtual Reality
The study is a randomized controlled study planned to determine the effect of the VRBaby-Pump application applied to mothers who gave birth preterm, on the mother's breast milk expression experience, transition process, and milk…
- Trial name
- NCT06164223
- Testing
- VR Baby Pump
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Akdeniz University