Clinical trials: Gene Expression
Preterm Labour
Monocyte Chemotactic Protein-1 (MCP-1) Expressing Monocytes to Predict Preterm Delivery: PhenoMAP Study
The threat of preterm labour (PTL) is the first cause of hospitalization in the course of pregnancy. Its diagnostic is based on clinical examination with a positive predictive value of about 40 %.
- Trial name
- PHENOMAP (NCT01340222)
- Testing
- biological samples
- Where
- France
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Milk Expression, Breast
Efficacy of Breast Milk in Healing of Skin Damage
The population of the research will be preterm infants born 35-36 weeks of gestation, hospitalized in the Neonatal Intensive Care Unit of Karaman State Hospital, whose skin is damaged due to Intravenous (IV) vascular access…
- Trial name
- NCT05390372
- Testing
- human milk, Routine care group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Adrenal Sufficiency
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein
Males and females may exhibit different responses to testing of adrenal function. The hormones responsible for controlling adrenal function are ACTH (adrenocorticotropic hormone or corticotropin) and CRH (corticotropin-releasing…
- Trial name
- NCT00196001
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Posner Schlossman Syndrome
Patient Registry of Posner-Schlossman Syndrome
Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure.
- Trial name
- NCT03233477
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Peking University
Brain Markers
Brain and Eye Markers of Facial Expression Recognition and Disorders Associated with Autistic Symptoms
In everyday life, it is necessary to adjust one's behavior and reactions in order to interact and communicate with others in an appropriate manner.
- Trial name
- MARQUEURS (NCT05635812)
- Testing
- Neuropsychological assessment, EEG experimentation, Oculometry experimentation
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Stroke, TIA
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.
- Conditions
- Stroke, TIA, Ischemic Stroke, Ischemic
- Trial name
- FCG (NCT05518305)
- Testing
- Medical Imaging
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hepatitis B
Pilot Study: Gene Expression Profiling of Immune Response to HBV Vaccination in Healthy Volunteers
Vaccines have been responsible for preventing millions of deaths and extending the average human lifespan. Effective vaccines stimulate the cells of the immune system to activate genes and associated functions that bring about…
- Trial name
- NCT02055365
- Testing
- Hepatitis B Vaccine (Recombinant)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Polycystic Ovary Syndrome
Adipose Expression of Leptin, Adiponectin and IL-6 and Plasma Levels of Adipocytokines in Women With and Without Polycystic Ovary Syndrome (PCOS)
The purpose of the study was to investigate adipose expression and plasma levels of different adipocytokine, which may play a role in the pathophysiology of PCOS.
- Trial name
- NCT01088061
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Diabetes and Healthy Control, FTO Gene Expression
Effects of Exercise Intervention and Confounding Factors on Type II Diabetic Muscles
The aim of the first year of this three-year plan is to analyze and compare the muscle quality of lower limb muscle (microcirculation, muscle performance and mechanical characteristics) and maximal aerobic exercise capacity in…
- Conditions
- Diabetes and Healthy Control, FTO Gene Expression, Aerobic Exercise Intervention or Home Exercise, Pre-training and Post-training
- Trial name
- NCT03869411
- Testing
- supervised aerobic exercise or home-based aerobic exercise
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea and Genes Expression
Obstructive sleep apnea is a multi-component disease. This study will test the hypotheses that hypoxia per se modulates gene expression in animal model of sleep apnea and these results may be translated with alterations that…
- Trial name
- HIP (NCT01392339)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Healthy
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects
Explore the detoxifying potential of hydroxytyrosol and its effects on Phase II enzyme expression (leading to xenobiotics detoxification in the liver).
- Trial name
- NCT02273622
- Testing
- hydroxytyrosol
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Anorexia Nervosa
Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa
The objective of this study is to identify the patterns of brain activity in reward circuitry that promote symptoms of anorexia nervosa.
- Trial name
- NCT03275545
- Testing
- No intervention
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiovascular Disease
Decoding Your Diet (DYD)
Our study will determine if a high quality AHA plant-based diet intervention can promote a genetic signature that is protective against CVD.
- Trial name
- DYD (NCT05904639)
- Testing
- Decoding Your Diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Autism Spectrum Disorder, High-functioning Autism
Neuralized1 and RGS14 Genes
Autism is a broad spectrum neurodevelopmental disease. Some individuals with ADS by high cognitive functions are diagnosed with High Functioning Autism (HFA).
- Conditions
- Autism Spectrum Disorder, High-functioning Autism, Healthy
- Trial name
- NCT04865198
- Testing
- Neurl1 gene expression, RGS14 gene expression
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Endometrial Endocrine Regulation, Progesterone Supplementation in Women After Mifepristone
Endometrial Transcript Profile with Progesterone After Post-ovulatory Mifepristone
The goal of this exploratory trial is to determine the endometrial gene expression profile induced by exogenous progesterone after postovulatory administration of mifepristone.
- Trial name
- NCT06616077
- Testing
- Micronized Progesterone 600 mg, mifepristone 200 mg
- Where
- Chile
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Reproductive Health Research Insritute, Chile
Chronic Obstructive Pulmonary Disease (COPD), Smoking
The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD, commonly known as chronic bronchitis and emphysema).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Chronic Bronchitis
- Trial name
- NCT00974064
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Non-melanomatous Skin Cancer, Precancerous Condition
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer.
- Trial name
- NCT00099112
- Testing
- microarray analysis, biopsy, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Obesity, Type 2 Diabetes
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women
In this study, we will clarify the degree of insulin resistance and characterise muscle glucose metabolism and gene expression in a group of overweight healthy women.
- Conditions
- Obesity, Type 2 Diabetes, Polycystic Ovary Syndrome
- Trial name
- NCT00145392
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Breast Milk Expression
Galactagogue Use in Lactating Women With Low Milk Supply
This study aims to determine whether a 20-day supplement with either Oat Mama Lactation Supplement, moringa, or shatavari has any impact on milk production through an increase in serum prolactin levels when compared to the…
- Trial name
- NCT05398367
- Testing
- Galactagogue Supplement for Treatment of Low Milk Supply
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Winthrop University
Breast Milk Collection
Human Milk Sample Composition in Israeli Mothers and Correlation With Their Diet
The study will collect human milk from 100 mother of term infants 2-3m after delivery and from 50 mothers of preterm infants 14 and 30 days after delivery.
- Trial name
- NCT02596295
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Enzymotec