Clinical trials: Gene Expression
Hepatitis B
Expression of Th9 Cells and Poor/Non-responsiveness to Hepatitis B Vaccination
An observational study will be performed in subjects aged 3-65 years old to describe the dynamic changes of cellular immunity after vaccination of hepatitis B vaccine, and to find out the expression levels of Th9 cells and IL9 in…
- Trial name
- NCT01441609
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Beijing Municipal Science & Technology Commission
Obesity
TIFACT Study - Tissue Factor Expression by Adipose Tissue in Extremely Obese Subjects.
Tissue factor is the main activator of coagulation cascades. Excessive tissue factor expression is made responsible of thrombosis in a number of clinical situations including thrombosis in contact with atherosclerotic plaques.
- Trial name
- NCT00379704
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Study to Evaluate the Effect of Botanical Dietary Supplements on Inflammation in Healthy People
The purpose of the study is to evaluate the effect of botanical dietary supplements on inflammation in healthy people with different genetic responses to inflammation.
- Trial name
- NCT00303238
- Testing
- Rose hips extract + blueberry/blackberry extract + resveravine, Rose hips extract + blueberry/blackberry extract + Aframomum melegueta extract, Rose hips extract + resveravine + Aframomum melegueta extract
- Where
- 8 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Obesity (BMI>30), Neuroinflammation
Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity
This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with…
- Trial name
- NCT07782411
- Testing
- Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha
- Where
- Mexico
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Autonomous University of Morelos
Anti Aging
Effects of a Proprietary Blend of Herbal Extract Supplement on Cellular Detoxification, Inflammation, and Cumulative Cognitive Index as Well as Gene Expression in Middle-Aged Adult Women
Determine the effects of 8 week Investigational Supplement on cellular detoxification and gene expression profiles
- Trial name
- Pharmanex (NCT01598272)
- Testing
- Vitality product AM + Vitality product PM
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus
The Genetics of Adipose Tissue Function and Its Link to Type 2 Diabetes and Heart Disease
Obesity is a major risk factor for Type 2 diabetes. However, two obese people of the same height and weight can have very different risks of the condition.
- Trial name
- FATFUNgenes (NCT04040595)
- Testing
- Abdominal fat biopsy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Exercise, Pulmonary Rehabilitation
The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis
The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid…
- Conditions
- Exercise, Pulmonary Rehabilitation, Interstitial Lung Disease, Long Noncoding RNA
- Trial name
- NCT07320846
- Testing
- Standard pulmonary rehabilitation programme, Resistive threshold inspiratory muscle training, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Healthy
Effect of a Multivitamin/Multimineral/Phytochemical Dietary Supplement on Indices of Human Health
This is a global transcriptomics and epigenetic pilot study designed to identify changes in gene expression and DNA methylation patterns following the consumption of an MVM/phytochemical supplement in a small group of healthy…
- Trial name
- NCT03146312
- Testing
- MVM/phytochemical supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
User Experience With Virtual Assistants in Service Settings
Effects of Virtual Assistant Features on User Experience in Service Settings
This study examines how the characteristics and performance of virtual assistants influence user experience in service settings.
- Trial name
- AVir4Services (NCT07666295)
- Testing
- High Anthropomorphism, Low Anthropomorphism, Accurate Virtual Assistant Response
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Chronic Lymphocytic Leukemia
B-type Chronic Lymphocytic Leukemia (B-CLL) Subgroups: Maturation Stage and Gene Expression
B type chronic lymphocytic leukemia (B-CLL) is the most prevalent leukemia in the western world. It is a disease that occurs primarily in aging individuals and occurs more frequently in males than females.
- Trial name
- NCT01030913
- Where
- United States
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Type 2 Diabetes
Changes of Biomarkers in Response to Training and Antioxidant Treatment
The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants.
- Trial name
- NCT00638560
- Testing
- Vitamin C, Vitamin E, Antioxidant treatment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Healthy Volunteer
Use of Pap Smear Derived Cells to Analyze the Expression of SLC6A14 and GPR81 Genes
SLC6A14 may serve as a biomarker for cervical dysplasia or cervical cancer.
- Trial name
- NCT03039868
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Marfan Syndrome
Clinical Variability in Marfan Syndrome
Marfan syndrome is an autosomal dominant connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1). Penetrance of FBN1 mutations is complete but intra and inter familial clinical expressivity is extremely…
- Trial name
- Variarfan (NCT01707563)
- Testing
- skin punch biopsy and molecular biology, fibroblast culture and molecular biology
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overactive Bladder, Children
Gene Expression in the Overactive Bladder in Children
The aim of this study (the hypothesis) is to identify differences in the gene expression profile in the bladder muscle and hereby gain greater knowledge about the muscular mechanisms that cause overactive bladder and daytime…
- Trial name
- NCT02086058
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
NSCLC
Expression and Sequence of Calcium Channels in Non-small Cell Lung Carcinoma (NSCLC)
Calcium is an extremely important ion used in our body for many processes. One of its tasks is to control gene expression. Cells intake calcium from their surroundings though special calcium channels located on the surface…
- Trial name
- NCT02283021
- Testing
- A biopsy sample
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cardiovascular Disease
Expression of Longevity Genes in Response to Extended Fasting
The purpose of this study is to evaluate the effect of fasting on physical changes associated with cardiovascular disease.
- Trial name
- FEELGOOD (NCT01059760)
- Testing
- Fasting First, Fed First
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Coronary Heart Disease, Periodontal Diseases
Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart…
- Trial name
- NCT04127474
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital