Clinical trials: Gene Mutation
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Pulmonary Neoplasms, Solitary Pulmonary Nodules
Diagnosis of Lung Lesions by Endobronchial Ultrasound With an Alternative Guide Sheath
The purpose of this study is to examine the usefulness of a balloon covered sheath as a guide sheath in endobronchial ultrasound guided transbronchial biopsy and bronchial brushing cytology for diagnosis of peripheral lung lesions
- Trial name
- NCT00922155
- Testing
- guide sheath
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Cladribine Tablets as an Exit Therapy Strategy
The objective of the study is to evaluate the effectiveness of CladT, in terms of disease stability and safety, as the last treatment option in ageing MS patients vs treatment continuation and discontinuation This observational…
- Conditions
- Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
- Trial name
- CLADREXIT (NCT06887426)
- Testing
- Cladribine
- Where
- France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Strasbourg, France
Asparagine Synthetase Deficiency, Genetic Diseases, Inborn
Study on the Mechanism of Neurodevelopment Dysplasia of Fetal Brain Caused by ASNS Gene Mutation
The investigators propose to analyze a brain sample and/or peripheral blood by single cell RNA seq from aborted embryos with ASNS mutation.
- Trial name
- NCT03587155
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Metastatic Gastrointestinal Stromal Tumors (GIST)
A Study of Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment
This study is a multicenter, prospective, randomized controlled Phase II clinical trial. The primary endpoint is to evaluate the efficacy and safety of regorafenib combined with envafolimab compared to physician's choice in…
- Trial name
- NCT06772233
- Testing
- regorafenib combined with envafolimab, Control Group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Breast Cancer
Study of Safety and Efficacy of Dapagliflozin + Metformin XR Versus Metformin XR in Participants With HR+, HER2-, Advanced Breast Cancer While on Treatment With Alpelisib and Fulvestrant
This study was designed to assess the safety and efficacy of the combination of dapagliflozin plus metformin extended release (XR) compared with metformin XR during treatment with alpelisib plus fulvestrant in participants with…
- Trial name
- EPIK-B4 (NCT04899349)
- Testing
- Alpelisib, Fulvestrant, Metformin XR
- Where
- 2 sites in United States, Malaysia
- Volunteers
- 2 people
- Sponsor
- Novartis Pharmaceuticals
Non-small Cell Lung Cancer Metastatic, Non-small Cell Lung Cancer Recurrent
A Prospective Observational Study Evaluating c-MET Expression and EGFR Gene Mutation Correlation With Erlotinib Response
1. Trial design: Prospective observational study 2. Target population: 200 NSCLC patients with histologically or cytologically confirmed stage IV or recurrent NSCLC who have progressive disease after 1st line chemotherapy who…
- Trial name
- MENTOR (NCT01523340)
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Chonnam National University Hospital
Non-Small Cell Lung Cancer、EGFR Sensitive Mutation
Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation
To evaluate the safety and tolerance of MCLA-129 combined with Befotertinib in patients with advanced non-small cell lung cancer with EGFR-sensitive mutations.
- Trial name
- NCT06015568
- Testing
- MCLA-129: 1500mg or 2000mg IV Q2W, Befotertinib: 75 mg or 100 mg Po QD
- Where
- 3 sites in China
- Volunteers
- 172 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
NSCLC, Stage III
Combination of Almonertinib and Concurrent Chemoradiotherapy in Unresectable Stage III NSCLC
This is a Prospective, open, single arm study to evaluate the efficacy and safety of the almonertinib combined with concurrent chemoradiotherapy in unresectable stage III NSCLC with EGFR mutation
- Trial name
- NCT04952168
- Testing
- Almonertinib
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Yuan Chen
Hematological Neoplasm, Graft-Versus-Host Disease
The Influence of TaKeTiNa Music Therapy, Traditional Chinese Acupuncture and Clown Theatrical Performance on Quality of Life and the Therapeutic Process of Patients Undergoing Allogenic Stem Cell Transplantation
The allogenic stem cell transplantation (aSCT), the only curative approach for many hematological diseases, often leads to severe diseases or chronic conditions, leaving patients with physical disabilities and severe depression…
- Conditions
- Hematological Neoplasm, Graft-Versus-Host Disease, Depression, Stem Cell Transplant Complications
- Trial name
- TriCAM (NCT02976558)
- Testing
- Clown theatrical Performance, Acupuncture, Music Therapy TaKeTiNa
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Pancreatic Ductal Adenocarcinoma
A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy
This is an observational precision oncology study designed to collect and analyze data that allows us to characterize the safety and efficacy of several different mitogen-activated protein kinase kinase inhibitor (MEKi) -based…
- Trial name
- NCT05630989
- Testing
- combination therapy with no MEKi, combination therapy with MEKi-HCQ, combination therapy with MEKi-EGFRi
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mandana Kamgar, MD
Ankle Disease, Ankle (Ligaments); Instability (Old Injury)
Is Harvesting the Peroneus Brevis an Alternative in Anatomic Ankle Ligament Reconstruction
Severe ankle sprains are the most frequent reason for emergency trauma consultations. Between 30% and 80% of sprains result in sequelae such as pain, joint derangement or instability.
- Trial name
- NCT06655350
- Testing
- MRI, Measure
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
PSR Ovarian Cancer With a BRCA Mutation
Olaparib Expanded Access Program for BRCA Mutated Platinum Sensitive Relapsed High Grade Epithelial Ovarian Cancer Patients in Japan
This is a single-arm, open label, expanded access program to provide access to olaparib tablets for relapsed high-grade epithelial ovarian cancer patients (including patients with primary peritoneal and / or fallopian tube…
- Trial name
- NCT03063710
- Testing
- olaparib
- Where
- 2 sites in Japan
- Sponsor
- AstraZeneca
Study Genetic Basis of Infantile Onset Diabetes Mellitus
Gene Study for Infantile Onset Diabetes
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
- Trial name
- NCT03169413
- Testing
- Human Leucocytic antigen typing and mutation of adenosine triphosphate sensitive K channel gene in diabetic patients diagnosed under the age of one year.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alveolar Bone Loss
Mineralized Dentin Graft Versus Beta-Tricalcium Phosphate for Alveolar Ridge Preservation
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge.
- Trial name
- NCT07812610
- Testing
- Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate, Extraction Socket Healing Without Bone Graft
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Soaad Tolba Mohammed Tolba Badawi
Sarcopenia
A Study of the Telerehabiliation Intervention Effect of the Tai Chi Exercise on Elderly With Sarcopenia
Sarcopenia is an age-related disease characterized by a progressive decrease in skeletal muscle content and loss of muscle function.
- Trial name
- NCT05767710
- Testing
- AI telerehabilitation - Tai Chi, general telerehabilitation - Tai Chi, traditional rehabilitation - Tai Chi
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Northeast Normal University
Acute Myeloid Leukemia (AML), Acute Promyelocytic Leukemia (APL)
Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the AMLProfiler
This clinical study will demonstrate the accuracy of the chromosomal aberration and gene mutation markers of the AMLProfiler molecular diagnostic assay and generate clinical performance data to support a Pre-Market Approval (PMA)…
- Conditions
- Acute Myeloid Leukemia (AML), Acute Promyelocytic Leukemia (APL), Refractory Anemia With Excess of Blasts (RAEB)
- Trial name
- NCT01463410
- Where
- 5 sites in United States, Germany and 2 more
- Volunteers
- 264 people
- Sponsor
- Skyline Diagnostics BV
Mastalgia
A New Treatment Option for Mastalgia
The main objective of this study is to determine the effectiveness of transcutaneous electrical nerve stimulation (TENS) treatment on pain and quality of life in mastalgia, which treatment has not yet reached a consensus.
- Trial name
- NCT06168110
- Testing
- TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Ankara University
Clinical Decision Support System
Does a Clinical Support System for Parenteral Nutrition (PN) Facilitate the Judgement on Choosing the Most Effective Commercial Solution Per Patient (and Modify it, if Necessary)?
Standard formulas of PN have been developed and provided to patients. Only few randomized controlled studies compared standardized vs individualized PN.
- Trial name
- CDSS (NCT05670613)
- Testing
- CDSS Canceling
- Where
- Greece
- Volunteers
- 67 people
- Sponsor
- Iaso Maternity Hospital, Athens, Greece
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