Clinical trials: Gene Polymorphism
Alopecia Areata, TLRs
Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study
Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses.
- Trial name
- TLR7-AA (NCT07454876)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Infectious Keratitis
Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis
This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal…
- Trial name
- ABSOSASAPOIK (NCT04213313)
- Testing
- Treatment of bacterial keratitis, Treatment of fungal keratitis, Treatment of viral keratitis
- Where
- China
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma in Children, Wheezing
Secondhand Smoking in Asthmatic Children
This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.
- Trial name
- NCT03099902
- Testing
- Lung function, White blood cell DNA extraction, Urinary testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Obesity
Investigation of Genetic Marker Associated With Obesity in Koreans
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the obese patients and the normal control will be performed to find genetic marker for obesity
- Trial name
- IGM-OK (NCT01341860)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Cigarette Smoking Behavior
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
In this study, potential associations between several genetic polymorphisms and nicotine dependence will be examined. The relative reinforcing efficacy of cigarettes using the forced-choice procedure will be assessed.
- Trial name
- NCT02921282
- Testing
- Genotype dopamine, Genotype cannabinoids
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Metformin, Organic Cation Transporter 2
A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers
The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in…
- Conditions
- Metformin, Organic Cation Transporter 2, Polymorphism,Single Nucleotide
- Trial name
- NCT01237522
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Irritable Bowel Syndrome, Children
Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)
Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.
- Trial name
- NCT01131442
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy
Bioavailability and Metabolism of Voriconazole in Relation to Its Modulation by the CYP2C19 Genetic Polymorphism
The purposes of this study are: To determine the absolute bioavailability of voriconazole after a single oral dose (400 mg voriconazole [VFEND brand]) in comparison to intravenous (i.v.) administration (400 mg VFEND, equivalent…
- Trial name
- NCT00175994
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Dyslipidemias, Single Nucleotide Polymorphism
VDR SNPs & 25OHD Correlated With Dyslipidemia
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese.
- Trial name
- NCT04707612
- Testing
- No intervention.
- Where
- China
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Generalized Adult Periodontitis
Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
- Trial name
- SEGPPAH (NCT02423304)
- Testing
- blood samples collected from all patients
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Developmental Delays
The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.
- Trial name
- NCT02523989
- Testing
- study group
- Where
- Taiwan
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Premature Ejaculation
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy
Premature ejaculation (PE) is a prevalent male sexual dysfunction that affects as many as 20-30% of men regardless of age and ethnicity.The International Society for Sexual Medicine defines premature ejaculation as a male sexual…
- Trial name
- NCT07057011
- Testing
- Paroxetine 20 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Valley University
Dementia
Apolipoprotein E Gene and Functional MRI
1. Apolipoprotein E gene (ApoE) is the most important genetic factor for Alzheimer disease (AD) and an important genetic factor for outcome of brain injury situations. 2.
- Trial name
- fMRI (NCT01287819)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Psoriasis
Evaluation of IL 12B Genetic Polymorphism (rs3213094)
Psoriasis is a skin disorder that is chronic proliferative and inflammatory in nature. Extensor surfaces, scalp, and lumbosacral area are covered in erythematous plaques with silvery scales.
- Trial name
- NCT07128472
- Testing
- Humira
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South Valley University
Quality of Life
Effects of Genetic Variation on the Efficacy of Aerobic Exercise
This study investigates whether, after six weeks of exercise, a genetic variant (Val66Met) in the gene that makes a molecule (BDNF) important for brain health and function, influences the beneficial effects of a further session…
- Trial name
- NCT03670186
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McMaster University
COVID-19 Respiratory Infection
Gene Polymorphism of IL17 and IL 23
rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins.
- Trial name
- COVID 19IL17 (NCT04948515)
- Testing
- laboratory test
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Asthma in Children, Genetic Disease
Association Between Genetic Polymorphisms and Type 2 Asthma in Children
To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2…
- Conditions
- Asthma in Children, Genetic Disease, Inflammation
- Trial name
- SNP (NCT06840717)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Thrombocytopenia
Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP
Immune thrombocytopenia (ITP) is an autoimmune condition characterized by increased platelet destruction and suppression of production resulting in isolated thrombocytopenia.
- Trial name
- FoxP3ITP (NCT05410249)
- Testing
- Serum IL10 By ELISA, SNP -3279 A/C of FOXP3, SNP-924 A/G Of FOXP3
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sohag University
Ulcerative Colitis, Vitamin D Deficiency
Observation of the Effect of Vitamin D Supplementation on Chronic Course of Patients With Ulcerative Colitis Based on Vitamin D Receptor Fok I Gene Polymorphism
Aims:Prospectively observe the effects of Vitamin D drops supplementation on the chronic course of ulcerative colitis patients, analyze whether the effect of Vitamin D drops on UC patients is affected by factors such as disease…
- Conditions
- Ulcerative Colitis, Vitamin D Deficiency, Vitamin D Supplement
- Trial name
- NCT04309058
- Testing
- Vitamin D drops
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University