Clinical trials: General Anesthetic Drug Adverse Reaction
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
General Anesthetic Drug Adverse Reaction
Effect of Remimazolam on Postoperative Delirium
Remimazolam is a novel benzodiazepine with ultra-short onset and offset of its effect. It can be used for general anesthesia. However, classical benzodiazepine such as midazolam was reported to increase the risk of postoperative…
- Trial name
- RED (NCT06180876)
- Testing
- remimazolam, propofol
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Zhihong LU
General Anesthetic Drug Adverse Reaction
Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction
In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or Tegilerdine.
- Trial name
- NCT07323043
- Testing
- Tegilerdine, Sufentanil
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Lianyungang
Topical Anaesthesia, General Anesthetic Drug Adverse Reaction
Evaluation of Postoperative Pain in Cases Undergoing Cataract Surgery Under Topical Versus General Anesthesia
Comparison between cataract surgery under local versus general anesthesia regarding postoperative pain, complications and patient satisfaction and need for rescue analgesic intake after surgery The results will be followed up at…
- Conditions
- Topical Anaesthesia, General Anesthetic Drug Adverse Reaction, Cataract
- Trial name
- NCT07287683
- Testing
- Topical Anaesthesia group, General Anaesthesia group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Geriatrics, Hypotension on Induction
Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery
In this observational study, we will assess cFT by Carotid ultrasound and IVC collapsibility index for prediction of hypotension after induction of general anesthesia in geriatric patients undergoing elective surgery.
- Conditions
- Geriatrics, Hypotension on Induction, General Anesthetic Drug Adverse Reaction, Elective Surgery
- Trial name
- NCT06814054
- Testing
- Carotid Artery Corrected Flow Time measurement, Inferior vena cava collapsibility index
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Tanta University
General Anesthetic Drug Adverse Reaction
Predicting Outcomes Using Infra-red SEnsors, a Feasibility Study.
The aim of this study is to investigate if it is feasible to use a protocol in which avoiding oxygen desaturation in the brain during general anaesthesia can reduce the risk of negative postoperative behavior changes in children.
- Trial name
- PORPOISE-F (NCT06515080)
- Testing
- Near Red Infrascopy
- Where
- 5 sites in Australia, Belgium and 3 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University
General Anesthetic Drug Adverse Reaction
Postoperative Effects of Propofol Versus Sevoflurane Anesthesia
Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.
- Trial name
- NCT05935930
- Testing
- Propofol 10 MG/ML Injection, Sevoflurane Inhalation Liquid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour Teaching Hospital
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
General Anesthetic Drug Adverse Reaction, Perioperative/Postoperative Complications
Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency.
- Trial name
- NCT05208502
- Testing
- DSA monitor
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
Endobronchial Metastases, Bronchoesophageal Fistula
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
This study is a prospective, randomized, controlled trial. In this study, 30 patients who underwent endotracheal tumor resection under rigid bronchoscope or stent placement for acquired tracheoesophageal fistula were selected as…
- Conditions
- Endobronchial Metastases, Bronchoesophageal Fistula, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT05468671
- Testing
- Remimazolam, Propofol, Rocuronium
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Zhejiang Cancer Hospital
General Anesthetic Drug Adverse Reaction
PKPD of Rocuronium and Sugammadex Profile in Pediatric Patients
The aim of the study is to assess the pharmacokinetic and pharmacodynamic properties of rocuronium and sugammadex and their clinical effect in the terms of both the relaxation of paralysed muscles (rocuronium) and the reversal of…
- Trial name
- NCT04851574
- Testing
- Sugammadex Injection
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Poznan University of Medical Sciences
General Anesthetic Drug Adverse Reaction
Romanian Entropy Clinical Study Network
The critically ill patient is one of the most complex cases with regard to the optimization of the anesthesia, as well as postoperative management.
- Trial name
- ROEntropy (NCT03210077)
- Testing
- Monitoring
- Where
- Romania
- Volunteers
- 500 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Postoperative Delirium, Elderly Patient
Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium
The intravenous administration of anesthetic agents by a controller automatically-guided by an index of cerebral activity (i.e. the bispectral index) decreases the incidence of postoperative delirium, compared with an…
- Conditions
- Postoperative Delirium, Elderly Patient, General Anesthetic Drug Adverse Reaction
- Trial name
- AG-DPO (NCT03705728)
- Testing
- Propofol, Sevoflurane, Remifentanil automatic
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Clinical, France
General Anesthetic Drug Adverse Reaction
Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia
There is accumulating evidence that inappropriate depth of anaesthesia is associated with increased risk of postoperative complications including risk of death.
- Trial name
- NCT02617680
- Testing
- desflurane - oxygen in air, desflurane - oxygen in nitric oxide
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Hradec Kralove
Coronary Artery Bypass Graft Redo, General Anesthetic Drug Adverse Reaction
The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting
This study is to assess the effect of desflurane on myocardial function in patents who underwent coronary artery bypass grafting.
- Trial name
- NCT02213718
- Testing
- Desflurane, propofol, sufentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huazhong University of Science and Technology