Clinical trials: General Anesthetics
Anesthesia, General, Anesthesia, Endotracheal
Comparison of Carotid Peak Systolic Velocity Variation With Aortic Peak Systolic Velocity Variation in Pediatric Non-Cardiac Surgery
The purpose of this study is to evaluate whether carotid Doppler peak systolic velocity can be an easy to measure possible surrogate for echocardiographic measurement of aortic peak systolic velocity variation which is an index…
- Conditions
- Anesthesia, General, Anesthesia, Endotracheal, Mechanical Ventilation, Fluid Responsiveness
- Trial name
- NCT03155555
- Testing
- Measurement of aortic and carotid Doppler peak systolic velocity variation
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypotension, Anesthesia
Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia.
- Trial name
- NCT02624050
- Testing
- Methohexital, Propofol
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Airway Complications
Frequency of Airway Complications During General Anaesthesia After Introducing Five Handling Adaptations
The purpose of this study is to determine if five simple adaptations in airway management of patients undergoing general anaesthesia can reduce minor and major airway complications.
- Trial name
- Papaya (NCT02743767)
- Testing
- Introducing five different treating adaptations
- Where
- Switzerland
- Volunteers
- 7,455 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pediatric Obesity, Obesity, Childhood
PErioperAtive CHildhood ObesitY
The incidence of childhood obesity is at epidemic levels and increasing in the UK. Obese adults are considered a high-risk group of patients for general anaesthesia with published national guidelines on the best practice…
- Conditions
- Pediatric Obesity, Obesity, Childhood, Overweight and Obesity, Perioperative/Postoperative Complications
- Trial name
- PEACHY (NCT03994419)
- Testing
- Anaesthesia for surgery
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Safety Issues, Post Operative Pain
Safety and Efficacy of Wide Awake Local Anesthesia no Tourniquet Technique (WALANT) in Ankle Removal of Implant Surgery
Safety and efficacy of wide awake local anesthesia no torniquet technique (WALANT) in ankle surgery. Studying risks and benefits from WALANT compared to general anesthesia .
- Conditions
- Safety Issues, Post Operative Pain, Local Anesthetic Complication
- Trial name
- NCT05864664
- Testing
- Wide awake local anaesthesia no tourniquet technique
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ali Lari
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)
The aim of this randomized trial is to assess the efficacy of preventive analgesia using different peribulbar blocks (PBB) under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative nausea and…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain, Oculocardiac Reflex
- Trial name
- PBBVRS (NCT03413371)
- Testing
- paracetamol, 0,5 % bupivacaine with of 2% lidocaine, 1 % Ropivacaine
- Where
- Poland
- Volunteers
- 184 people
- Sponsor
- Medical University of Silesia
Quality of Postoperative Recovery
Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery
To explore the effect of subanesthetic-dose esketamine combined with different general anesthetic drugs on the quality of postoperative recovery in patients undergoing painless gastrointestinal endoscopy.
- Trial name
- NCT06976996
- Testing
- normal saline, esketamine, propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Northern Jiangsu People's Hospital
Endotracheal Extubation, Airway Anesthesia
BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia
During surgery, anaesthetists can use an endotracheal tube (ETT) to facilitate ventilation. At emergence from general anaesthesia, there are two techniques for removal of the ETT: (1) the ETT is removed when the child is waking…
- Conditions
- Endotracheal Extubation, Airway Anesthesia, Paediatric
- Trial name
- BELUGA (NCT07204990)
- Testing
- Direct removal of endotracheal tube, Laryngeal mask airway inserted following deep extubation
- Where
- 8 sites in United States, Australia and 4 more
- Volunteers
- 1,400 people
- Sponsor
- Telethon Kids Institute
Post-induction Hypotension
Evaluation of the Relation Between Patient Fasting Time and the Occurrence of PIH (Post Induction Hypotension)
This monocentre prospective trial aims to evaluate the relationship between fasting time and the occurence of PIH (post-induction hypotension).
- Trial name
- NCT07785635
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Neuromuscular Blockade
Reversal of Neuromuscular Blockade During the General Anaesthesia
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe…
- Trial name
- NCT04048655
- Testing
- Neostigmine, Combinations
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Desflurane, Anesthesia, General
The Effect of Anthropometrics on Desflurane Rise Time
Desflurane is increasingly used in general anesthesia. Its pharmacokinetic properties are known and its distribution is easily modeled. Yet these models fail in practice.
- Trial name
- NCT06026033
- Testing
- Desflurane induction
- Where
- Turkey (Türkiye)
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Anesthetic Gas Consumption and Cost-Effectiveness
Comparison of Different Ventilator and Vaporizer Technologies to Study Economic and Environmental Implications
The purpose of this study is to test whether or not the use of a low volume ventilator in an anesthesia machine reduces anesthetic costs significantly as compared to other high volume machines.
- Trial name
- NCT04851314
- Testing
- ICU certified ventilator, Non-ICU certified ventilator
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, Irvine
General Anaesthesia, Propofol
Blood Propofol Measurement During Anaesthesia Using Propofol Target Controlled Infusion
Propofol is a commonly used agent for sedation and anaesthesia in the intensive care unit and the operating room. The pharmacokinetics of propofol are difficult to predict in patients not conforming to the norms in which the…
- Conditions
- General Anaesthesia, Propofol, Target Controlled Infusion, Pharmacokinetics
- Trial name
- NCT01549639
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Analgesia
Analgesic Requirements for Lumbar Fixation With General Anaesthesia Versus Continuous Caudal Epidural
In this clinical study, the investigators will justify the current practice of combined continuous caudal epidural with general anaesthesia in adult patients undergoing lumbar fixation versus general anaesthesia.
- Trial name
- NCT06929611
- Testing
- Combined continous caudal epidural with general anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Rocuronium, Muscle Weakness
General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery
Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents.
- Conditions
- Rocuronium, Muscle Weakness, General Anaesthesia
- Trial name
- NCT04760912
- Testing
- Rocuronium, General anesthesia for surgery
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Centre Zagreb
Postoperative Recovery, General Anaesthesia
Intercultural Adaptation and Validation of the Ukrainian Quality of Recovery-15 Questionnaire
The Quality of Recovery 15-questionnaire (QoR-15) is used to assess postoperative quality of recovery after surgery and anesthesia from the patient's perspective.
- Conditions
- Postoperative Recovery, General Anaesthesia, Validation, Questionnaire
- Trial name
- NCT07510360
- Testing
- Quality of Recovery-15 questionnaire, Ukrainian version
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rostyslav Voloshchuk
Healthy
I-Gel Versus Disposable Laryngeal Mask (LMA) for General Anesthesia (GA) With Controlled Ventilation
Randomized controlled trial comparing performance of the I-gel and disposable Laryngeal Mask Airways under controlled ventilation. 200 patients, 100 in each arm. Measurement of peak airway and sealing pressures.
- Trial name
- IGE(L)MA (NCT00668278)
- Testing
- Insertion of laryngeal mask airway (AuraOnce mask), Insertion of I-gel airway, Measurement of airway pressures
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northern Health and Social Care Trust
Total Fluid Volume Decreased
Preoperative Ultrasound Guided Evaluation of SVC-CI and IVC -CI as Predictors of Hypotension After Induction of Anaesthesia in Major Onco-surgery
Patients undergoing major Oncosurgeries are fluid deficit due to preoperative fasting , inadequate intake due to disease hence prone to development of hypotension after induction of general anaesthesia owing to vasodilatory…
- Trial name
- SVC IVC CI (NCT05548920)
- Testing
- Ultrasound guided Superior Vena Cava Collapsibility Index, Inferior Vena Cava Collapsibility Index
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Hypotension on Induction
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Baseline Measurements For the ultrasound parameters, it is the average of three readings In supine position . The investigators will continuously monitoring during induction and 10 minutes after.
- Trial name
- NCT07370103
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infant Apnea, Surgical Procedure, Unspecified
Apneic Oxygénation by Nasal Canula During Infants Airway Management Study
This is a randomized clinical trial investigating the utility of apneic oxygenation via high flow nasal cannulae during airway management for infants general anaesthesia.
- Conditions
- Infant Apnea, Surgical Procedure, Unspecified, Airway Management
- Trial name
- Oxyeno (NCT03967769)
- Testing
- High Flow nasal Cannula
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Clermont-Ferrand